Characterizations of probability distributions via bivariate regression of record values

Bairamov et al. (Aust N Z J Stat 47:543-547, 2005) characterize the exponential distribution in terms of the regression of a function of a record value with its adjacent record values as covariates. We extend these results to the case of non-adjacent covariates. We also consider a more general setting involving monotone transformations. As special cases, we present characterizations involving weighted arithmetic, geometric, and harmonic means.Comment: accepted in Metrik

Effects of quarks on the formation and evolution of Z(3) walls and strings in relativistic heavy-ion collisions

We investigate the effects of explicit breaking of Z(3) symmetry due to the presence of dynamical quarks on the formation and evolution of Z(3) walls and associated QGP strings within Polyakov loop model. We carry out numerical simulations of the first order quark-hadron phase transition via bubble nucleation (which may be appropriate, for example, at finite baryon chemical potential) in the context of relativistic heavy-ion collision experiments. Using appropriate shifting of the order parameter in the Polyakov loop effective potential, we calculate the bubble profiles using bounce technique, for the true vacuum as well as for the metastable Z(3) vacua, and estimate the associated nucleation probabilities. These different bubbles are then nucleated and evolved and resulting formation and dynamics of Z(3) walls and QGP strings is studied. We discuss various implications of the existence of these Z(3) interfaces and the QGP strings, especially in view of the effects of the explicit breaking of the Z(3) symmetry on the formation and dynamical evolution of these objects.Comment: 17 pages, 9 figures, PDFLate

Effect of Fibonacci Modulation On Superconductivity

We have studied finite-sized single band models with short range pairing interactions between electrons in presence of diagonal Fibonacci modulation in one dimension. Two models, namely the attractive Hubbard model and the Penson-Kolb model, have been investigated at half-filling at zero temperature by solving the Bogoliubov-de Gennes equations in real space within a mean field approximation. The competition between ``disorder'' and the pairing interaction leads to a suppression of superconductivity (of usual pairs with zero centre-of-mass momenta) in the strong-coupling limit while an enhancement of the pairing correlation is observed in the weak-coupling regime for both the models. However, the dissimilarity of the pairing mechanisms in these two models brings about notable difference in the results. The extent to which the bond ordered wave and the $\eta$-paired (of pairs with centre-of-mass momenta = $\pi$) phases of the Penson-Kolb model are affected by the disorder has also been studied in the present calculation. Some finite size effects are also identified.Comment: 14 pages, 13 figure

The b quark low-scale running mass from Upsilon sum rules

The b quark low-scale running mass m_kin is determined from an analysis of the Upsilon sum rules in the next-to-next-to-leading order (NNLO). It is demonstrated that using this mass one can significantly improve the convergence of the perturbation series for the spectral density moments. We obtain m_kin(1 GeV) = 4.56 \pm 0.06 GeV. Using this result we derive the value of the MS-bar mass m: m(m) = 4.20 \pm 0.1 GeV. Contrary to the low-scale running mass, the pole mass of the b quark cannot be reliably determined from the sum rules. As a byproduct of our study we find the NNLO analytical expression for the cross section e+e- --> Q\bar Q of the quark antiquark pair production in the threshold region, as well as the energy levels and the wave functions at the origin for the ^1S_3 bound states of Q\bar Q.Comment: 22 pages, Late

Stationary Localized States Due to a Nonlinear Dimeric Impurity Embedded in a Perfect 1-D Chain

The formation of Stationary Localized states due to a nonlinear dimeric impurity embedded in a perfect 1-d chain is studied here using the appropriate Discrete Nonlinear Schr$\ddot{o}$dinger Equation. Furthermore, the nonlinearity has the form, $\chi |C|^\sigma$ where $C$ is the complex amplitude. A proper ansatz for the Localized state is introduced in the appropriate Hamiltonian of the system to obtain the reduced effective Hamiltonian. The Hamiltonian contains a parameter, $\beta = \phi_1/\phi_0$ which is the ratio of stationary amplitudes at impurity sites. Relevant equations for Localized states are obtained from the fixed point of the reduced dynamical system. $|\beta|$ = 1 is always a permissible solution. We also find solutions for which $|\beta| \ne 1$. Complete phase diagram in the $(\chi, \sigma)$ plane comprising of both cases is discussed. Several critical lines separating various regions are found. Maximum number of Localized states is found to be six. Furthermore, the phase diagram continuously extrapolates from one region to the other. The importance of our results in relation to solitonic solutions in a fully nonlinear system is discussed.Comment: Seven figures are available on reques

Specific detection of Aspergillus fumigatus in sputum sample of pulmonary tuberculosis patients by two-step PCR

The incidence of life-threatening systemic fungal infections has been increasing in recent years, and the increasing incidence has been correlated with increasing numbers of immunocompromisedpatients. We developed a two-step PCR assay that specifically amplifies a region of the 18S rRNA gene that is highly conserved in Aspergillus fumigatus. This assay allows direct and rapid detection of down to 10 fg of Aspergillus fumigatus DNA corresponding to 1 to 5 colony forming unit (CFU) per ml of sputum sample of pulmonary tuberculosis patients. The two primer pairs that produced PCR productswith the highest sensitivity and species specificity were the Aspergillus fumigatus primers AFU7S and AFU7AS, which amplified a fragment of 405 bp, followed by AFU5S and AFU5AS, which produced aninternal fragment of 236 bp. PCR has been shown to be a highly sensitive diagnostic tool for the detection of infectious fungi specimens. Our point to the considerable potential clinical value of thissimple, specific, rapid, and inexpensive PCR assay is for improving the means of early diagnosis of systemic aspergillosis tuberculosis patients

The Kramers equation simulation algorithm I. Operator analysis

Using an operatorial formalism, we study the Kramers equation and its applications to numerical simulations. We obtain classes of algorithms which may be made precise at every desired order in the time step $\epsilon$ and with a set of free parameters which can be used to reduce autocorrelations. We show that it is possible to use a global Metropolis test to restore Detailed Balance.Comment: 32 pages, REVTeX 3.0, IFUP-TH-2

Functional Cellular Anti-Tumor Mechanisms are Augmented by Genetic Proteoglycan Targeting.

While recent research points to the importance of glycans in cancer immunity, knowledge on functional mechanisms is lacking. In lung carcinoma among other tumors, anti-tumor immunity is suppressed; and while some recent therapies boost T-cell mediated immunity by targeting immune-checkpoint pathways, robust responses are uncommon. Augmenting tumor antigen-specific immune responses by endogenous dendritic cells (DCs) is appealing from a specificity standpoint, but challenging. Here, we show that restricting a heparan sulfate (HS) loss-of-function mutation in the HS sulfating enzyme Ndst1 to predominantly conventional DCs (Ndst1f/f CD11cCre+ mutation) results in marked inhibition of Lewis lung carcinoma growth along with increased tumor-associated CD8+ T cells. In mice deficient in a major DC HS proteoglycan (syndecan-4), splenic CD8+ T cells showed increased anti-tumor cytotoxic responses relative to controls. Studies examining Ndst1f/f CD11cCre + mutants revealed that mutation was associated with an increase in anti-tumor cytolysis using either splenic CD8+ T cells or tumor-infiltrating (TIL) CD8+ T cells purified ex-vivo, and tested in pooled effector-to-target cytolytic assays against tumor cells from respective animals. On glycan compositional analysis, HS purified from Ndst1f/f CD11cCre + mutant DCs had reduced overall sulfation, including reduced sulfation of a tri-sulfated disaccharide species that was intriguingly abundant on wildtype DC HS. Interestingly, antigen presentation in the context of major histocompatibility complex class-I (MHC-I) was enhanced in mutant DCs, with more striking effects in the setting of HS under-sulfation, pointing to a likely regulatory role by sulfated glycans at the antigen/MHC-I - T-cell interface; and possibly future opportunities to improve antigen-specific T cell responses by immunologic targeting of HS proteoglycans in cancer