Pierre Robin syndrome: a case report

Pierre Robin syndrome is characterized by micrognathia, glossoptosis and palatal malformation. We report a case of a 6 day neonate who presented with complaints of feeding and respiratory difficulty and was later diagnosed as case of Pierre Robin syndrome

Document clustering for knowledge synthesis and project portfolio funding decision in R&D organizations

The paper discusses a method of using document clustering for information/knowledge synthesis and decision facilitation in R&D organisations. The emerging methodologies of machine learning, artificial intelligence and data science in conjunction with fuzzy mathematics can be optimally exploited to catalyse development of information bank for research organisations. This knowledge ecosystem can be utilized by the proposed mechanism to accelerate and reinforce interdisciplinary research for R&D organisations and empower them to make efficacious information-driven decisions related to project portfolio selection and proposal funding

Deep Reinforcement Learning with Importance Weighted A3C for QoE enhancement in Video Delivery Services

Adaptive bitrate (ABR) algorithms are used to adapt the video bitrate based on the network conditions to improve the overall video quality of experience (QoE). Recently, reinforcement learning (RL) and asynchronous advantage actor-critic (A3C) methods have been used to generate adaptive bit rate algorithms and they have been shown to improve the overall QoE as compared to fixed rule ABR algorithms. However, a common issue in the A3C methods is the lag between behaviour policy and target policy. As a result, the behaviour and the target policies are no longer synchronized which results in suboptimal updates. In this work, we present ALISA: An Actor-Learner Architecture with Importance Sampling for efficient learning in ABR algorithms. ALISA incorporates importance sampling weights to give more weightage to relevant experience to address the lag issues with the existing A3C methods. We present the design and implementation of ALISA, and compare its performance to state-of-the-art video rate adaptation algorithms including vanilla A3C implemented in the Pensieve framework and other fixed-rule schedulers like BB, BOLA, and RB. Our results show that ALISA improves average QoE by up to 25%-48% higher average QoE than Pensieve, and even more when compared to fixed-rule schedulers.Comment: Number of pages: 10, Number of figures: 9, Conference name: 24th IEEE International Symposium on a World of Wireless, Mobile and Multimedia Networks (WoWMoM

Klippel-Feil syndrome: a case report

Klippel-Feil Syndrome (KFS) is defined as congenital fusion of two or more cervical vertebrae. The most common signs are short neck, low hairline at the back of head and restricted mobility of neck. We report a case of a neonate who presented with complaint of respiratory difficulty and later diagnosed as case of Klippel-Feil syndrome

Formulation, Development and Evaluation of Montelukast Sodium Chewable Tablets.

The oral route of drug administration is the most important method of administering drug for systemic effects. Except in certain case the parental route is not routinely used for self administration, e.g. insulin. The topical route of administration has only recently been employed to deliver drugs to the body for systemic effect. The parental route of administration is important in treating medical emergencies in which the subject is comatose or cannot swallow. Nevertheless it is probable that at least 90% of all drugs used to provide systemic effect are administered by oral route. When a new drug is discovered one of the first question a pharmaceutical company asks is whether or not the drug can be effectively administered for its intended effect by oral route. Drugs that are administered orally, solid oral dosage forms represent the preferred class of product. Tablet and capsules represent unit dosage forms in which usual dose of drug has been accurately placed. It can be concluded that chewable tablets of Montelukast sodium can be prepared by wet granulation method using croscarmellose sodium as superdisintegrant. Chewable tablets of Montelukast sodium with 3% of croscarmellose sodium gave better drug release of 98% with minimum disintegration time with pleasant taste .This will improve patient compliance and increase in bioavailability

Development of gum acacia-alginate microspheres of metformin hydrochloride: In vitro characterization

The metabolic disorder type 2 diabetes mellitus continuously increasing in the world. This disorder affecting all age groups. Thus, this disorder is now creating burden on healthcare sector, especially in case of underdeveloped countries. Nowadays many conventional drug delivery systems are available for management of diabetes mellitus. The gums and mucilages are polysaccharide obtained from various plant. Thus, present study is started with aim to formulate gum acacia based microspheres for gastroretentive delivery of metformin hydrochloride. The drug loaded microspheres were formulated using ionic gelation method and evaluated for physicochemical properties, mucoadhesive potential, swelling index and in vitro drug release study. The microspheres showed acceptable physicochemical properties, good swelling ability, mucoadhesive potential and sustained drug release. Thus, gum acacia could be promising alternative for fabrication of gastroretentive drug delivery system.&nbsp

Neurological manifestations in speech after snake bite: a rare case

The patient was admitted after reporting a snake bite from which he later developed neurological signs and symptoms among which a flaccid dysarthria. The patient underwent speech therapy and showed significant improvement over a short period of time. The favorable outcome of the present study highlights the role of speech therapy in such a case, where it often remains un-emphasized

Complementary Organizational Mechanisms: A Case Study on Information Technology Business Value

The complex relationships between organizational practices have been the focus of information technology business value (ITBV) research in recent years. There appears to be a discernible trend toward a more nuanced view in which the effects of information technology (IT), various organizational practices and their relationships are systematically investigated. There is also emerging evidence of recent focus in organizational factors and an increasing shift towards “complementarities” in which organizational performance is linked to combining organizational practices in synergistic ways. The objective of this paper is to investigate important issues in ITBV research by examining complementarities of various resources within an organization. The goal of this paper is to establish a framework for analyzing different configurations of complementarities. The Configuration and Interestingness framework (CIF) proposed in this paper provides evidence on how important the understanding of those complex relationship structures amongst organizational practices is to maximizing business value. This framework serves as a preliminary attempt to reveal different possible classes of complementarities structures

Unilateral macular branch retinal vein occlusion in a healthy Indian woman following coronavirus disease vaccination: a case report and comprehensive literature review

Background: The coronavirus disease (COVID-19) vaccines exert ocular adverse effects, including episcleritis, scleritis, anterior and recurrent uveitis, acute macular neuroretinopathy, paracentral acute middle maculopathy, ophthalmic vein thrombosis, Graves’ disease, arteritic anterior ischemic optic neuropathy,  non-arteritic anterior ischemic optic neuropathy, central serous chorioretinopathy, Vogt-Koyanagi-Harada disease, multifocal choroiditis, cranial nerve palsies such as facial or abducens nerve palsy, acute zonal occult outer retinopathy, acute zoster ophthalmicus following re-activation of the varicella-zoster virus, acute retinal necrosis, and multiple evanescent white dot syndrome. In this case report, we explored the possibility of macular branch retinal vein occlusion and its association with COVID-19 vaccination. Case Presentation: A 44-year-old healthy woman presented with unilateral nonprogressive blurring of vision in the right eye (OD). Her best-corrected distance visual acuity (BCDVA) in OD was 20 / 40. The anterior-segment evaluation was normal. Fundus evaluation of the OD revealed macular branch vein occlusion. She had a history of COVID-19 vaccination within 1 month. The interleukin-6 level was elevated six folds to 30.5 pg / mL. However, COVID-19 immunoglobulin G (IgG) antibodies were negative. Infective etiologies, such as tuberculosis and dengue, were ruled out. Spectral-domain optical coherence tomography (SD-OCT) of the OD showed hyperreflective dots in the posterior vitreous, inner retinal swelling, and cystoid changes in the macula. The maximum central macular thickness was 486 mm. A single dose of bevacizumab was administered at OD intravitreally. At the final follow-up 2.5 months later, her BCDVA had improved to 20 / 20 OD. Fundus evaluation revealed fewer retinal hemorrhages and cotton wool spots. SD-OCT of the OD showed a normal foveal contour and absence of cystoid spaces. Her maximum central macular thickness was 236 mm. Conclusions: A temporal effect of vein occlusion secondary to COVISHIELD™ vaccination may occur in the absence of systemic risk factors. The interleukin-6 level was elevated, and the remaining blood test results were within normal limits. Since this is a case report, it is limited by the absence of strong evidence to prove this causal relationship between macular branch retinal vein occlusion and the specific brand of COVID-19 vaccination