Histopathological and immunohistochemical evaluation of 84 uterine sarcomas according to current literature

OBJECTIVE It was aimed to reevaluate uterine sarcoma cases diagnosed in our institution within the last 20 years according to current information and to provide intra-departmental standardization in the differential diagnosis and reporting. METHODS Totally 84 uterine sarcoma cases were re-examined. Recurrence, metastasis, and prognostic data were collected from the patient files. Immunohistochemistry panel consisting of CD10, h-caldesmon, and cyclin D1 was applied to the representative tumor tissues. The relationships between the parameters studied were evaluated statistically. RESULTS Statistically significant differences were found between different histopathological types of uterine sar-comas (US) in terms of age distribution, tumor diameter, mitotic index, necrosis, depth of myometrial invasion, cervical, adnexial and/or omental involvement, lymphovascular invasion, lymph node metas-tasis, recurrence, and distant metastasis. Statistically significant correlation was determined between the prognosis of the patients and mitotic activity of their tumors and the presence of distant metastasis. The immunohistochemistry panel was found to have significant contribution to the histomorphological ex-amination in the differential diagnosis. CONCLUSION Routine use of CD10, h-caldesmon, and cyclin D1 in the histopathological evaluation of US and es-tablishing an updated standard checklist was thought to be beneficial for the differential diagnosis and reporting prognostic parameters

Place of Cholecystectomy in Children with Uncomplicated Gallstones

Conclusions: The risk factors have no influence on the development of gallstone-induced complications in children. Gallstones were cured with cholecystectomy; however, some complaints persisted in risk-free and uncomplicated gallstones. We think that if there are no risk factors in patients with uncomplicated gallstones, the patients should not receive surgerybut be closely monitored

A Benign Rare Lesion of the Breast: Giant Epidermal Inclusion Cyst

An epidermal inclusion cyst can be seen at any location. Epidermal cysts are commonly found on the scalp, face, trunk, neck, and extremities. They are rarely seen in the breast parenchyma. These benign lesions are important in that they may undergo neoplastic differentiation, although very rarely. Epidermoid cysts usually develop as a result of the implantation of superficial epidermal tissue into the dermis or subcutaneous tissue after trauma or surgical procedures. In this study, a 37-year-old female patient who underwent a histopathological examination that showed a 10-cm epidermal cyst without a history of trauma or a surgical procedure was discussed

Recommendations for hepatitis B immunoglobulin and antiviral prophylaxis against hepatitis B recurrence after liver transplantation

The combination of hepatitis B immunoglobulin and potent nucleos(t)ide analogs after liver transplantation is considered as the standard of care for prophylaxis against hepatitis B virus recurrence. However, the recommended doses, route of administration, and duration of HBIG administration remain unclear. Moreover, hepatitis B immunoglobulin-free prophylaxis with potent nucleos(t)ide analogs has shown promising disease outcomes in preventing hepatitis B virus recurrence. The current recommendations, produced by the Turkish Association for the Study of the Liver, Acute Liver Failure and Liver Transplantation Special Interest Group, suggest a reduced need for hepatitis B immunoglobulin administration with effective long-term suppression of hepatitis B virus replication using potent nucleos(t) ide analogs after liver transplantation

Recommendations for hepatitis B immunoglobulin and antiviral prophylaxis against hepatitis B recurrence after liver transplantation

The combination of hepatitis B immunoglobulin and potent nucleos(t)ide analogs after liver transplantation is considered as the standard of care for prophylaxis against hepatitis B virus recurrence. However, the recommended doses, route of administration, and duration of HBIG administration remain unclear. Moreover, hepatitis B immunoglobulin-free prophylaxis with potent nucleos(t)ide analogs has shown promising disease outcomes in preventing hepatitis B virus recurrence. The current recommendations, produced by the Turkish Association for the Study of the Liver, Acute Liver Failure and Liver Transplantation Special Interest Group, suggest a reduced need for hepatitis B immunoglobulin administration with effective long-term suppression of hepatitis B virus replication using potent nucleos(t)ide analogs after liver transplantation