7 research outputs found
Highly Chemoselective and Enantioselective Catalytic Oxidation of Heteroaromatic Sulfides via High-Valent Manganese(IV)–Oxo Cation Radical Oxidizing Intermediates
A manganese complex with a porphyrin-like
ligand that catalyzes the highly chemoselective and enantioselective
oxidation of heteroaromatic sulfides, including imidazole, benzimidazole,
indole, pyridine, pyrimidine, pyrazine, <i>sym</i>-triazine,
thiophene, thiazole, benzothiazole, and benzoxazole, with hydrogen
peroxide is described, furnishing the corresponding sulfoxides in
good to excellent yields and enantioselectivities (up to 90% yield
and up to >99% ee) within a short reaction time (0.5 h). The practical
utility of the method has been demonstrated in the gram-scale synthesis
of chiral sulfoxide. Mechanistic studies, performed with <sup>18</sup>O-labeled water (H<sub>2</sub><sup>18</sup>O), hydrogen peroxide
(H<sub>2</sub><sup>18</sup>O<sub>2</sub>), and cumyl hydroperoxide,
reveal that a high-valent manganese–oxo species is generated
as the oxygen atom delivering agent via carboxylic acid assisted heterolysis
of O–O bonds. Density functional theory (DFT) calculations
were also carried out to give further insight into the mechanism of
manganese-catalyzed sulfoxidation. On the basis of the theoretical
study, the coupled high-valent manganeseÂ(IV)–oxo cation radical
species, which bears obvious similarities with that of reactive intermediates
in the catalytic oxygenation reactions based on the cytochrome P450
and metalloporphyrin models, has been proposed as the reactive oxidant
in the non-heme manganese catalyst system
Asymmetric Epoxidation of Alkenes Catalyzed by a Porphyrin-Inspired Manganese Complex
A novel strategy for catalytic asymmetric epoxidation of a wide variety of olefins by a porphyrin-inspired chiral manganese complex using H<sub>2</sub>O<sub>2</sub> as a terminal oxidant in excellent yield with up to greater than 99% ee has been successfully developed
An Effective Method for the Construction of Esters Using Cs<sub>2</sub>CO<sub>3</sub> as Oxygen Source
An
effective method for the construction of esters from acyl chloride
and halohydrocarbon using Cs<sub>2</sub>CO<sub>3</sub> as an oxygen
source was achieved for the first time. The methodology has a wide
scope of substrates and can be scaled up. The study of a preliminary
reaction mechanism demonstrated that the O in the products comes from
Cs<sub>2</sub>CO<sub>3</sub> and this esterification proceeds through
a free radical reaction. It was also found that CO<sub>2</sub> can
also be used in this esterification reaction as an oxygen source
Synergistic H<sub>4</sub>NI–AcOH Catalyzed Oxidation of the C<sub>sp<sup>3</sup></sub>–H Bonds of Benzylpyridines with Molecular Oxygen
The
oxidation of benzylpyridines forming benzoylpyridines was achieved
based on a synergistic H<sub>4</sub>NI–AcOH catalyst and molecular
oxygen in high yield under solvent-free conditions. This is the first
nonmetallic catalytic system for this oxidation transformation using
molecular oxygen as the oxidant. The catalytic system has a wide scope
of substrates and excellent chemoselectivity, and this procedure can
also be scaled up. The study of a preliminary reaction mechanism demonstrated
that the oxidation of the C<sub>sp<sup>3</sup></sub>–H bonds
of benzylpyridines was promoted by the pyridinium salts formed by
AcOH and benzylpyridines. The synergistic effect of H<sub>4</sub>NI–AcOH
was also demonstrated by control experiments
Iron/ABNO-Catalyzed Aerobic Oxidation of Alcohols to Aldehydes and Ketones under Ambient Atmosphere
We report a new FeÂ(NO<sub>3</sub>)<sub>3</sub>·9H<sub>2</sub>O/9-azabicycloÂ[3.3.1]Ânonan-<i>N</i>-oxyl catalyst system
that enables efficient aerobic oxidation of a broad range of primary
and secondary alcohols to the corresponding aldehydes and ketones
at room temperature with ambient air as the oxidant. The catalyst
system exhibits excellent activity and selectivity for primary aliphatic
alcohol oxidation. This procedure can also be scaled up. Kinetic analysis
demonstrates that C–H bond cleavage is the rate-determining
step and that cationic species are involved in the reaction
Exhaustive Hydrodefluorination or Deuterodefluorination of Trifluoromethylarenes via Metal-Free Photoredox Catalysis
Perfluoroalkyl compounds are persistent environmental
pollutants
due to their chemical and thermal stability. Hydrodefluorination is
one of the most promising strategies for the disposal of fluorine-containing
compounds, which has attracted much attention from a broad spectrum
of scientific communities. Herein, we disclose a metal-free, visible-light-promoted
protocol for the exhaustive hydrodefluorination of a wide variety
of trifluoromethylarenes with up to 95% yields. Moreover, methyl-d3 groups can be obtained
via deuterium water with a D ratio of up to 94%
Asymmetric Epoxidation of Olefins with Hydrogen Peroxide by an in Situ-Formed Manganese Complex
Asymmetric
epoxidation of a variety of cis, trans, terminal, and
trisubstituted olefins in excellent yields (up to 94%) and enantioselectivities
(>99% ee) by an in situ-formed manganese complex using H<sub>2</sub>O<sub>2</sub> has been developed. A relationship between the hydrophobicity
of the catalyst imposed by ligand and the catalytic activity has been
observed. The influence of the amount and identity of the acid additive
was examined, and improved enantioselectivities were achieved through
the use of a catalytic amount of a carboxylic acid additive