An Effective Method for the Construction of Esters Using Cs₂CO₃ as Oxygen Source

Abstract

An effective method for the construction of esters from acyl chloride and halohydrocarbon using Cs₂CO₃ as an oxygen source was achieved for the first time. The methodology has a wide scope of substrates and can be scaled up. The study of a preliminary reaction mechanism demonstrated that the O in the products comes from Cs₂CO₃ and this esterification proceeds through a free radical reaction. It was also found that CO₂ can also be used in this esterification reaction as an oxygen source