Experimental realization of a highly secure chaos communication under strong channel noise

A one-way coupled spatiotemporally chaotic map lattice is used to contruct cryptosystem. With the combinatorial applications of both chaotic computations and conventional algebraic operations, our system has optimal cryptographic properties much better than the separative applications of known chaotic and conventional methods. We have realized experiments to pratice duplex voice secure communications in realistic Wired Public Switched Telephone Network by applying our chaotic system and the system of Advanced Encryption Standard (AES), respectively, for cryptography. Our system can work stably against strong channel noise when AES fails to work.Comment: 15 pages, 5 figure

Role of long non-coding RNA in chemoradiotherapy resistance of nasopharyngeal carcinoma

Nasopharyngeal carcinoma (NPC) is a malignant tumor originating from the nasopharyngeal epithelial cells. Common treatment methods for NPC include radiotherapy, chemotherapy, and surgical intervention. Despite these approaches, the prognosis for NPC remains poor due to treatment resistance and recurrence. Hence, there is a crucial need for more comprehensive research into the mechanisms underlying treatment resistance in NPC. Long non coding RNAs (LncRNAs) are elongated RNA molecules that do not encode proteins. They paly significant roles in various biological processes within tumors, such as chemotherapy resistance, radiation resistance, and tumor recurrence. Recent studies have increasingly unveiled the mechanisms through which LncRNAs contribute to treatment resistance in NPC. Consequently, LncRNAs hold promise as potential biomarkers and therapeutic targets for diagnosing NPC. This review provides an overview of the role of LncRNAs in NPC treatment resistance and explores their potential as therapeutic targets for managing NPC

Dynamic Modeling and Analysis of Demagnetizing Rotor of Permanent Magnet Synchronous Motor

This study performs a dynamic modeling and analysis of the axial uniform demagnetization rotor of a motor to investigate the demagnetization peculiar for permanent magnet synchronous motor (PMSM). First, the air-gap change in the motor is analyzed by constructing a dual coordinate system of stator and rotor, and the unbalanced magnetic pull (UMP) model under uniform demagnetization and eccentricity is constructed. Second, combined with the UMP and the self-gravity, a dynamic model of the rotor under a uniform demagnetization and eccentricity is established. Lastly, the accuracy of the mathematical model of UMP under uniform demagnetization and eccentricity is confirmed by the mutual corroboration of Maxwell simulation and MATLAB calculation; and based on the dynamics model, the dynamic characteristics of the rotor system under different degrees of uniform demagnetization are studied. This study provides a theoretical basis for the accurate demagnetization fault diagnosis and vibration control of PMSMs in the future

Spatial–Temporal Characteristics and Driving Factors of the Coupling Coordination between Population Health and Economic Development in China

Promoting the coordinated development of population health and the economy is an important part of building a “Healthy China” and promoting high-quality economic development. Based on the systematic construction of the population health and economic development evaluation index system, this paper uses the coupled coordination model, geodetector, and geographically weighted regression (GWR) to comprehensively measure the population health level and economic development level at the provincial scale in China in 2000 and 2015, and reveals the spatial and temporal evolution characteristics of the coupled coordination relationship between the population health level and economic development level at the provincial scale in China from 2000 to 2015 and its driving factors. The results show the following: (1) China’s population health and economic development are in a high-level coupling stage, and the coupling level increases slightly with time; spatially, two types of running-in coupling and high-level coupling coexist; the coupling degree in the eastern and central regions tends to increase, while the coupling degree in the western region tends to weaken. (2) China’s population health and economic development are in a good coupling coordination stage as a whole, and the coupling coordination degree has an increasing trend; spatially, the coupling coordination degree shows high spatial differentiation characteristics in the east and low in the west; the good and high-quality coupling coordination type area tends to expand to the west, while the moderate coupling coordination type area tends to shrink to the west; there is also positive spatial agglomeration of coupling coordination degree, and the spatial agglomeration is gradually enhanced. (3) The coupling coordination of China’s population health and economic development is driven by multiple factors such as natural conditions, health resources, culture quality, and urbanization level; the interaction between factors is stronger than that of a single factor, and the driving effect of each factor also shows significant spatial heterogeneity. This study is intended to provide a scientific basis for promoting harmonious population health and economic development

Nestin Modulates Airway Smooth Muscle Cell Migration by Affecting Spatial Rearrangement of Vimentin Network and Focal Adhesion Assembly

Airway smooth muscle cell migration plays a role in the progression of airway remodeling, a hallmark of allergic asthma. However, the mechanisms that regulate cell migration are not yet entirely understood. Nestin is a class VI intermediate filament protein that is involved in the proliferation/regeneration of neurons, cancer cells, and skeletal muscle. Its role in cell migration is not fully understood. Here, nestin knockdown (KD) inhibited the migration of human airway smooth muscle cells. Using confocal microscopy and the Imaris software, we found that nestin KD attenuated focal adhesion sizes during cell spreading. Moreover, polo-like kinase 1 (Plk1) and vimentin phosphorylation at Ser-56 have been previously shown to affect focal adhesion assembly. Here, nestin KD reduced Plk1 phosphorylation at Thr-210 (an indication of Plk1 activation), vimentin phosphorylation at Ser-56, the contacts of vimentin filaments to paxillin, and the morphology of focal adhesions. Moreover, the expression of vimentin phosphorylation-mimic mutant S56D (aspartic acid substitution at Ser-56) rescued the migration, vimentin reorganization, and focal adhesion size of nestin KD cells. Together, our results suggest that nestin promotes smooth muscle cell migration. Mechanistically, nestin regulates Plk1 phosphorylation, which mediates vimenitn phosphorylation, the connection of vimentin filaments with paxillin, and focal adhesion assembly

Effects of Error Modulation-Based Visual and Haptic Feedback Fusion Strategies on Motor Learning and Motivation

Visual or haptic feedback based on error modulation has been used to improve the effect of robot-assisted rehabilitation training. However, there are several investigations on the effects of error modulation-based visual and haptic feedback fusion strategies on motor learning and motivation. To observe the influence of different feedback fusion strategies on motor learning and motivation, a parallel controlled study was conducted, dividing 30 healthy subjects into three groups with similar skill levels. The no error modulation group received visual and haptic feedback without error modulation; the visual amplification haptic reduction group received visual error amplification combined with haptic error reduction, and the visual reduction haptic amplification (VRHA) group received visual error reduction combined with haptic error amplification. Each subject implemented a trajectory-tracking task with an upper limb rehabilitation robot. They went through baseline, training, assessment, and generalization tests and completed 340 consecutive tracking movements. To evaluate motor learning and motivation, the average tracking error, the root mean square (RMS) of surface electromyography (sEMG) signals, and the intrinsic motivation inventory scale were all examined. In the assessment tests, the average tracking error was significantly decreased in all three groups. In particular, the VRHA group had a larger reduction in average tracking error in the generalization test, lower RMS of sEMG signals both in the assessment and generalization tests and higher perceived competence in the assessment tests. The VRHA fusion strategy significantly improved the subjects’ motor learning and transfer ability, decreased muscle activation, and increased motor learning motivation. These findings may provide some new insights for multisensory feedback fusion technology in the application of rehabilitation robots