An Exponential Quantum Projection Filter for Open Quantum Systems

An approximate exponential quantum projection filtering scheme is developed for a class of open quantum systems described by Hudson- Parthasarathy quantum stochastic differential equations, aiming to reduce the computational burden associated with online calculation of the quantum filter. By using a differential geometric approach, the quantum trajectory is constrained in a finite-dimensional differentiable manifold consisting of an unnormalized exponential family of quantum density operators, and an exponential quantum projection filter is then formulated as a number of stochastic differential equations satisfied by the finite-dimensional coordinate system of this manifold. A convenient design of the differentiable manifold is also presented through reduction of the local approximation errors, which yields a simplification of the quantum projection filter equations. It is shown that the computational cost can be significantly reduced by using the quantum projection filter instead of the quantum filter. It is also shown that when the quantum projection filtering approach is applied to a class of open quantum systems that asymptotically converge to a pure state, the input-to-state stability of the corresponding exponential quantum projection filter can be established. Simulation results from an atomic ensemble system example are provided to illustrate the performance of the projection filtering scheme. It is expected that the proposed approach can be used in developing more efficient quantum control methods

A pancreatic mixed neuroendocrine-non-neuroendocrine neoplasms (MiNEN) (NET and undifferentiated carcinoma of the pancreas with osteoclast-like giant cells) with metastatic neuroendocrine component to the liver

Undifferentiated carcinoma of the pancreas with osteoclast-like giant cells (UCOGCs) is an extremely rare morphologically and clinically distinct variant of pancreatic ductal adenocarcinoma (PDAC), exhibiting a characteristic component of reactive osteoclast-like giant cells admixed with neoplastic mononuclear cells. Sommers and Meissner first described it in 1954 as an “unusual carcinoma of the pancreas”. Later it acquired many different names. In 2010, the WHO classified these tumors as a variant of PDAC under the heading of “undifferentiated carcinoma with osteoclast-like giant cells”. Here we describe the first case of pancreatic mixed neuroendocrine-non-neuroendocrine neoplasms (MiNEN) composed of UCOGC and pancreatic neuroendocrine tumor (NET), which occurred in a 78-year-old man with biliary colic and pancreatitis. The mass did not respond to the chemotherapy, and he soon developed liver metastasis from the NET component, and unfortunately, the patient passed away 10 months later. Since UCOGC is extremely rare, and its association with NET has not been reported yet, our case expands the knowledge regarding its unusual presentation and poor prognosis

NANOCOMPOSITES OF POLY(LACTIC ACID) REINFORCED WITH CELLULOSE NANOFIBRILS

A chemo-mechanical method was used to prepare cellulose nanofibrils dispersed uniformly in an organic solvent. Poly(ethylene glycol) (PEG 1000) was added to the matrix as a compatibilizer to improve the interfacial interaction between the hydrophobic poly(lactic acid) (PLA) and the hydrophilic cellulose nanofibrils. The composites obtained by solvent casting methods from N,N-Dimethylacetamide (DMAc) were characterized by tensile testing machine, atomic force microscope (AFM), scanning electron microscope (SEM), and Fourier transform infrared spectroscopy (FT-IR). The tensile test results indicated that, by adding PEG to the PLA and the cellulose nanofibrils matrix, the tensile strength and the elongation rate increased by 56.7% and 60%, respectively, compared with the PLA/cellulose nanofibrils composites. The FT-IR analysis successfully showed that PEG improved the intermolecular interaction, which is based on the existence of inter-molecular hydrogen bonding among PLA, PEG, and cellulose nanofibrils

Effective inhibition of foot-and-mouth disease virus (FMDV) replication in vitro by vector-delivered microRNAs targeting the 3D gene

<p>Abstract</p> <p>Background</p> <p>Foot-and-mouth disease virus (FMDV) causes an economically important and highly contagious disease of cloven-hoofed animals. RNAi triggered by small RNA molecules, including siRNAs and miRNAs, offers a new approach for controlling viral infections. There is no report available for FMDV inhibition by vector-delivered miRNA, although miRNA is believed to have more potential than siRNA. In this study, the inhibitory effects of vector-delivered miRNAs targeting the 3D gene on FMDV replication were examined.</p> <p>Results</p> <p>Four pairs of oligonucleotides encoding 3D-specific miRNA of FMDV were designed and selected for construction of miRNA expression plasmids. In the reporter assays, two of four miRNA expression plasmids were able to significantly silence the expression of 3D-GFP fusion proteins from the reporter plasmid, p3D-GFP, which was cotransfected with each miRNA expression plasmid. After detecting the silencing effects of the reporter genes, the inhibitory effects of FMDV replication were determined in the miRNA expression plasmid-transfected and FMDV-infected cells. Virus titration and real-time RT-PCR assays showed that the p3D715-miR and p3D983-miR plasmids were able to potently inhibit the replication of FMDV when BHK-21 cells were infected with FMDV.</p> <p>Conclusion</p> <p>Our results indicated that vector-delivered miRNAs targeting the 3D gene efficiently inhibits FMDV replication <it>in vitro</it>. This finding provides evidence that miRNAs could be used as a potential tool against FMDV infection.</p

Lentviral-mediated RNAi to inhibit target gene expression of the porcine integrin αv subunit, the FMDV receptor, and against FMDV infection in PK-15 cells

<p>Abstract</p> <p>Background</p> <p>shRNA targeting the integrin αv subunit, which is the foot-and-mouth disease virus (FMDV) receptor, plays a key role in virus attachment to susceptible cells. We constructed a RNAi lentiviral vector, iαv pLenti6/BLOCK -iT™, which expressed siRNA targeting the FMDV receptor, the porcine integrin αv subunit, on PK-15 cells. We also produced a lentiviral stock, established an iαv-PK-15 cell line, evaluated the gene silencing efficiency of mRNA using real-time qRT-PCR, integrand αv expression by indirect immunofluorescence assay (IIF) and cell enzyme linked immunosorbent assays (cell ELISA), and investigated the in vivo inhibitory effect of shRNA on FMDV replication in PK-15 cells.</p> <p>Results</p> <p>Our results indicated successful establishment of the iαv U6 RNAi entry vector and the iαv pLenti6/BLOCK -iT expression vector. The functional titer of obtained virus was 1.0 × 10⁶TU/mL. To compare with the control and mock group, the iαv-PK-15 group αv mRNA expression rate in group was reduced by 89.5%, whilst IIF and cell ELISA clearly indicated suppression in the experimental group. Thus, iαv-PK-15 cells could reduce virus growth by more than three-fold and there was a > 99% reduction in virus titer when cells were challenged with 10²TCID₅₀of FMDV.</p> <p>Conclusions</p> <p>Iαv-PK-15 cells were demonstrated as a cell model for anti-FMDV potency testing, and this study suggests that shRNA could be a viable therapeutic approach for controlling the severity of FMD infection and spread.</p

Correlation of fundamental movement skills with health-related fitness elements in children and adolescents: A systematic review

ObjectiveTo examine the correlations between fundamental movement skills and health-related fitness elements (cardiopulmonary function, flexibility, body composition, muscle strength and endurance) in children and adolescents and investigate the evaluation methods and tools of fundamental movement skills and health-related fitness.MethodsSix electronic databases (Web of Science, PubMed, ProQuest, Scopus, EBSCO and CNKI) were searched, and the research literature on the correlation between children's and adolescents' fundamental movement skills and health-related fitness published since 2002 was collected. The guidelines of the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement and the Consolidated Standards of Reporting Trials (CONSORT) statement were used to evaluate the quality of the literature, and the sources, samples, measurement methods, main results and statistical data of the study were analyzed, summarized and discussed.ResultsAfter applying the inclusion and exclusion criteria, 49 studies were included. There were 13 tools for evaluating fundamental movement skills and 4 tools for evaluating comprehensive health-related fitness in the included literature. Sufficient research evidence supports a significant positive correlation between fundamental movement skills and cardiopulmonary function (10, 100%) and muscle strength and endurance (12, 100%), and most studies support the positive correlation between fundamental movement skills and flexibility (4, 66.7%), and the significant negative correlation between fundamental movement skills and body composition (29, 67.4%). Studies used skinfold, AF%, BF%, FM, and FFMI as evaluation methods. They showed a consistently significant negative correlation between body composition and fundamental movement skills (9, 100%), while BMI or waist circumference as evaluation methods showed no consistent significant negative correlation result (20, 58.8%). Moreover, in the sub-item evaluation of fundamental movement skills, object manipulation, locomotor and balance skills were all significantly and positively correlated with cardiopulmonary function and muscle strength and endurance. In contrast, locomotor skills were more closely related to body composition than object manipulation skills.ConclusionA significant correlation exists between children's and adolescents' fundamental movement skills and health-related fitness elements