A Body-Nonlinear Green's Function Method with Viscous Dissipation Effects for Large-Amplitude Roll of Floating Bodies

A novel time-domain body-nonlinear Green’s function method is developed for evaluating large-amplitude roll damping of two-dimensional floating bodies with consideration of viscous dissipation effects. In the method, the instantaneous wetted surface of floating bodies is accurately considered, and the viscous dissipation effects are taken into account based on the “fairly perfect fluid” model. As compared to the method based on the existing inviscid body-nonlinear Green’s function, the newly proposed method can give a more accurate damping coefficient of floating bodies rolling on the free surface with large amplitudes according to the numerical tests and comparison with experimental data for a few cases related to ship hull sections with bilge keels

Top-N Recommendation on Graphs

Recommender systems play an increasingly important role in online applications to help users find what they need or prefer. Collaborative filtering algorithms that generate predictions by analyzing the user-item rating matrix perform poorly when the matrix is sparse. To alleviate this problem, this paper proposes a simple recommendation algorithm that fully exploits the similarity information among users and items and intrinsic structural information of the user-item matrix. The proposed method constructs a new representation which preserves affinity and structure information in the user-item rating matrix and then performs recommendation task. To capture proximity information about users and items, two graphs are constructed. Manifold learning idea is used to constrain the new representation to be smooth on these graphs, so as to enforce users and item proximities. Our model is formulated as a convex optimization problem, for which we need to solve the well-known Sylvester equation only. We carry out extensive empirical evaluations on six benchmark datasets to show the effectiveness of this approach.Comment: CIKM 201

Combinations of antioxidants and/or of epigenetic enzyme inhibitors allow for enhanced collection of mouse bone marrow hematopoietic stem cells in ambient air

Hematopoietic cell transplantation (HCT) is a treatment for malignant and non-malignant disorders. However, sometimes the numbers of donor hematopoietic stem cells (HSC) are limiting, which can compromise the success of HCT. We recently published that collection and processing of mouse bone marrow (BM) and human cord blood cells in a hypoxic atmosphere of 3% O2 or in ambient air (~21% O2) in the presence of cyclosporine A yields increased numbers of HSC. We now show that collection and processing of mouse BM cells in ambient air in the presence of specific combinations of anti-oxidants and/or inhibitors of epigenetic enzymes can also enhance the collection of HSC, information of potential relevance for enhanced efficacy of HCT