51 research outputs found
MapNext: a software tool for spliced and unspliced alignments and SNP detection of short sequence reads
Simultaneous Ni Doping at Atom Scale in Ceria and Assembling into Well-Defined Lotuslike Structure for Enhanced Catalytic Performance
Oxide materials with redox capability have attracted worldwide attentions in many applications. Introducing defects into crystal lattice is an effective method to modify and optimize redox capability of oxides as well as their catalytic performance. However, the relationship between intrinsic characteristics of defects and properties of oxides has been rarely reported. Herein, we report a facile strategy to introduce defects by doping a small amount of Ni atoms (∼1.8 at. %) into ceria lattice at atomic level through the effect of microstructure of crystal on the redox property of ceria. Amazingly, a small amount of single Ni atom-doped ceria has formed a homogeneous solid solution with uniform lotuslike morphology. It performs an outstanding catalytic performance of a reduced T50 of CO oxidation at 230 °C, which is 135 °C lower than that of pure CeO2 (365 °C). This is largely attributed to defects such as lattice distortion, crystal defects and elastic strain induced by Ni dopants. The DFT calculation has revealed that the electron density distribution of oxygen ions near Ni dopant, the reduced formation energy of oxygen vacancy originated from local chemical effect caused by local distortion after Ni doping. These differences have a great effect on increasing the concentration of oxygen vacancies and enhancing the migration of lattice oxygen from bulk to a surface which is closely related to optimized redox properties. As a result, oxygen storage capacity and the associated catalytic reactivity has been largely increased. We have clearly demonstrated the change of crystal lattice and the charge distribution effectively modify its chemical and physical properties at the atomic scale
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A genomic copy number variant analysis implicates the MBD5 and HNRNPU genes in Chinese children with infantile spasms and expands the clinical spectrum of 2q23.1 deletion
Background: Infantile spasms (IS) is a specific type of epileptic encephalopathy associated with severe developmental disabilities. Genetic factors are strongly implicated in IS, however, the exact genetic defects remain unknown in the majority of cases. Rare mutations in a single gene or in copy number variants (CNVs) have been implicated in IS of children in Western countries. The objective of this study was to dissect the role of copy number variations in Chinese children with infantile spasms. Methods: We used the Agilent Human Genome CGH microarray 180 K for genome-wide detection of CNVs. Real-time qPCR was used to validate the CNVs. We performed genomic and medical annotations for individual CNVs to determine the pathogenicity of CNVs related to IS. Results: We report herein the first genome-wide CNV analysis in children with IS, detecting a total of 14 CNVs in a cohort of 47 Chinese children with IS. Four CNVs (4/47 = 8.5%) (1q21.1 gain; 1q44, 2q31.1, and 17p13 loss) are considered to be pathogenic. The CNV loss at 17p13.3 contains PAFAH1B1 (LIS1), a causative gene for lissencephaly. Although the CNVs at 1q21.1, 1q44, and 2q23.1 have been previously implicated in a wide spectrum of clinical features including autism spectrum disorders (ASD) and generalized seizure, our study is the first report identifying them in individuals with a primary diagnosis of IS. The CNV loss in the 1q44 region contains HNRNPU, a strong candidate gene recently suggested in IS by the whole exome sequencing of children with IS. The CNV loss at 2q23.1 includes MBD5, a methyl-DNA binding protein that is a causative gene of ASD and a candidate gene for epileptic encephalopathy. We also report a distinct clinical presentation of IS, microcephaly, intellectual disability, and absent hallux in a case with the 2q23.1 deletion. Conclusion: Our findings strongly support the role of CNVs in infantile spasms and expand the clinical spectrum associate with 2q23.1 deletion. In particular, our study implicates the HNRNPU and MBD5 genes in Chinese children with IS. Our study also supports that the molecular mechanisms of infantile spasms appear conserved among different ethnic backgrounds
When tropical and subtropical congeners met:Multiple ancient hybridization events within Eriobotrya were detected in the Yunnan-Guizhou Plateau, a tropical-subtropical transition area in China
Controlled Synthesis and Selective Adsorption Properties of Pr2CuO4 Nanosheets: a Discussion of Mechanism
Abstract Tetragonal-phase Pr2CuO4 nanosheets with a thickness of about 60 nm were synthesized using the coordination compound methods (CCMs), then used as highly efficient selective adsorbent towards malachite green (MG) in aqueous solutions. The Pr2CuO4 samples were characterized using X-ray diffraction (XRD), scanning electron microscopy (SEM), high-resolution transmission electron microscopy (HRTEM), X-ray photoelectron spectroscopy (XPS), UV-Vis diffuse reflectance spectrum (DRS), and standard Brunauer–Emmett–Teller (BET) methods. The maximum adsorption capacity (Q m ) of as-prepared samples was determined by adsorption isotherms with different adsorbent doses (m) of 0.03–0.07 g at 298, 318, and 338 K based on the Langmuir model. When m  0.07 g, effects of systemic mass loss and particle aggregation were discussed on the data deviation from the Langmuir model at 298 K. Based on the hydrogen bond and coordination bond, a possible mechanism of selective adsorption of MG by Pr2CuO4 is proposed, which was further verified by the adsorption experiments of CuO and Pr2O3 towards MG and competing-ion experiments. Finally, the theoretic studies were performed at DFT level to reveal the possible adsorption process
De Novo Assembly of Coding Sequences of the Mangrove Palm (Nypa fruticans) Using RNA-Seq and Discovery of Whole-Genome Duplications in the Ancestor of Palms.
Nypa fruticans (Arecaceae) is the only monocot species of true mangroves. This species represents the earliest mangrove fossil recorded. How N. fruticans adapts to the harsh and unstable intertidal zone is an interesting question. However, the 60 gene segments deposited in NCBI are insufficient for solving this question. In this study, we sequenced, assembled and annotated the transcriptome of N. fruticans using next-generation sequencing technology. A total of 19,918,800 clean paired-end reads were de novo assembled into 45,368 unigenes with a N50 length of 1,096 bp. A total of 41.35% unigenes were functionally annotated using Blast2GO. Many genes annotated to "response to stress" and 15 putative positively selected genes were identified. Simple sequence repeats were identified and compared with other palms. The divergence time between N. fruticans and other palms was estimated at 75 million years ago using the genomic data, which is consistent with the fossil record. After calculating the synonymous substitution rate between paralogs, we found that two whole-genome duplication events were shared by N. fruticans and other palms. These duplication events provided a large amount of raw material for the more than 2,000 later speciation events in Arecaceae. This study provides a high quality resource for further functional and evolutionary studies of N. fruticans and palms in general
Phylogenetic analysis and divergence time estimation.
<p>(A) The phylogenetic tree of the five monocots. The results are 100% supported by the 1,000 bootstraps analysis. (B) Estimation of divergence time. Blue bars indicate 95% confidence intervals.</p
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