14,625 research outputs found
The swap operation in the two-qubit Heisenberg XXZ model-effects of anisotropy and magnetic field
In this paper we study the swap operation in a two-qubit anisotropic XXZ
model in the presence of an inhomogeneous magnetic field. We establish the
range of anisotropic parameter within which the swap operation is feasible. The
swap errors caused by the inhomogeneous field are evaluated
Mdivi-1, a mitochondrial fission inhibitor, modulates T helper cells and suppresses the development of experimental autoimmune encephalomyelitis.
BACKGROUND: Unrestrained activation of Th1 and Th17 cells is associated with the pathogenesis of multiple sclerosis and its animal model, experimental autoimmune encephalomyelitis (EAE). While inactivation of dynamin-related protein 1 (Drp1), a GTPase that regulates mitochondrial fission, can reduce EAE severity by protecting myelin from demyelination, its effect on immune responses in EAE has not yet been studied.
METHODS: We investigated the effect of Mdivi-1, a small molecule inhibitor of Drp1, on EAE. Clinical scores, inflammation, demyelination and Drp1 activation in the central nervous system (CNS), and T cell responses in both CNS and periphery were determined.
RESULTS: Mdivi-1 effectively suppressed EAE severity by reducing demyelination and cellular infiltration in the CNS. Mdivi-1 treatment decreased the phosphorylation of Drp1 (ser616) on CD4+ T cells, reduced the numbers of Th1 and Th17 cells, and increased Foxp3+ regulatory T cells in the CNS. Moreover, Mdivi-1 treatment effectively inhibited IFN-γ+, IL-17+, and GM-CSF+ CD4+ T cells, while it induced CD4+ Foxp3+ regulatory T cells in splenocytes by flow cytometry.
CONCLUSIONS: Together, our results demonstrate that Mdivi-1 has therapeutic potential in EAE by modulating the balance between Th1/Th17 and regulatory T cells
Observations of a white-light flare associated with a filament eruption
We present observations of an M5.7 white-light flare (WLF) associated with a
small filament eruption in NOAA active region 11476 on 2012 May 10. During this
flare, a circular flare ribbon appeared in the east and a remote brightening
occurred in the northwest of the active region. Multi-wavelength data are
employed to analyze the WLF, including white light (WL), ultraviolet, extreme
ultraviolet, hard X-ray (HXR) and microwave. A close spatial and temporal
relationship between the WL, HXR and microwave emissions is found in this WLF.
However, the peak time of the WL emission lagged that of the HXR and microwave
emissions by about 1-2 minutes. Such a result tends to support the back-warming
mechanism for the WL emission. Interestingly, the enhanced WL emission occurred
at the two footpoints of the filament. Through forced and potential field
extrapolations, we find that the three-dimensional magnetic field in the flare
region has a fan-spine feature and that a flux rope lies under the dome-like
field structure. We describe the entire process of flare evolution into several
steps, each producing the sequent brightening below the filament, the circular
flare ribbons and the WL enhancement respectively. We suggest that reconnection
between the magnetic field of the filament and the overlying magnetic field or
reconnection within the flux rope leads to the WL enhancement.Comment: Accepted by Ap
Study of the system of tuberous root induction in vitro from Rehmannia glutinosa
This study investigated the induction system of tuberous root in vitro from Rehmannia glutinosa. The roles of plant growth substance, carbohydrates, and minerals were evaluated for induction and development of tuberous root in vitro. The results show that Murashige and Skoog (MS) contributed greatly to induction of tuberous root in vitro, followed by α-naphthalene acetic acid (NAA), sucrose and 6-benzyladenine (BA). The optimal medium was ¼ MS supplemented with 1.5 mgL-1 BA, 0.15 mgL-1 NAA and 5% sucrose. In addition, paclobutrazol (PP333) and methyl jasmonate (MeJA) also played an important role in induction of tuberous root in vitro, the most appropriate concentrations were 1 mgL-1 and 10 μmolL-1 respectively.Key words: Rehmannia glutinosa, tuberous root, tissue culture in vitro
Remote generation of entanglement for individual atoms via optical fibers
The generation of atomic entanglement is discussed in a system that atoms are
trapped in separate cavities which are connected via optical fibers. Two
distant atoms can be projected to Bell-state by synchronized turning off the
local laser fields and then performing a single quantum measurement by a
distant controller. The distinct advantage of this scheme is that it works in a
regime that , which makes the scheme insensitive to
cavity strong leakage. Moreover, the fidelity is not affected by atomic
spontaneous emission.Comment: 4 pages, 3 figure
Non-Hermitian coherent coupling of nanomagnets by exchange spin waves
Non-Hermitian physics has recently attracted much attention in optics and
photonics. Less explored is non-Hermitian magnonics that provides opportunities
to take advantage of the inevitable dissipation of magnons or spin waves in
magnetic systems. Here we demonstrate non-Hermitian coherent coupling of two
distant nanomagnets by fast spin waves with sub-50 nm wavelengths. Magnons in
two nanomagnets are unidirectionally phase-locked with phase shifts controlled
by magnon spin torque and spin-wave propagation. Our results are attractive for
analog neuromorphic computing that requires unidirectional information
transmission
Double-peaked Narrow Emission-line Galaxies in LAMOST Survey
We outline a full-scale search for galaxies exhibiting double-peaked profiles
of promi- nent narrow emission lines, motivated by the prospect of finding
objects related to merging galaxies, and even dual active galactic nuclei
candidates as by-product, from the Large Sky Area Multi-object Fiber
Spectroscopic Telescope (LAMOST) Data Re- lease 4. We assemble a large sample
of 325 candidates with double-peaked or strong asymmetric narrow emission
lines, with 33 objects therein appearing optically resolved dual-cored
structures, close companions or signs of recent interaction on the Sloan Dig-
ital Sky Survey images. A candidate from LAMOST (J074810.95+281349.2) is also
stressed here based on the kinematic and spatial decompositions of the
double-peaked narrow emission line target, with analysis from the
cross-referenced Mapping Nearby Galaxies at the Apache Point Observatory
(MaNGA) survey datacube. MaNGA en- ables us to constrain the origin of double
peaks for these sources, and with the IFU data we infer that the most promising
origin of double-peaked profiles for LAMOST J074810.95+281349.2 is the
`Rotation Dominated + Disturbance' structure.Comment: 13 pages, 9 figures, accepted by MNRA
Brain-specific Crmp2 deletion leads to neuronal development deficits and behavioural impairments in mice
Acknowledgements: This work was supported by grants from NSF (31430037/31271156/ 31270826) and MOST (2014CB942801/2012CB517904/2012YQ03026006) to Z.X.; from NIH (NS048271, MH105128) to G.-l.M., from NIH (NS047344) to H.S., and from NRASAD to E.K. and K.M.C. Author notes: Hongsheng Zhang, Eunchai Kang and Yaqing Wang: These authors contributed equally to this work.Peer reviewedPublisher PD
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