79 research outputs found
Electronic and transport properties of kinked graphene
Local curvature, or bending, of a graphene sheet is known to increase the
chemical reactivity presenting an opportunity for templated chemical
functionalization. Using first principles calculations based on density
functional theory (DFT) we investigate the reduction of the reaction barrier
for adsorption of atomic hydrogen at linear bends in graphene. We find a
significant lowering (15%) for realistic radii of curvature (20 {\AA}), and
that adsorption along the linear bend leads to a stable linear kink. We compute
the electronic transport properties of individual and multiple kink-lines, and
demonstrate how these act as efficient barriers for electron transport. In
particular, two parallel kink-lines form a graphene pseudo-nanoribbon structure
with a semi-metallic/semi-conducting electronic structure closely related to
the corresponding isolated ribbons; the ribbon band gap translates into a
transport gap for transport across the kink lines. We finally consider
pseudo-ribbon based heterostructures, and propose that such structures present
a novel approach for band gap engineering in nanostructured graphene.Comment: 7 pages, 5 figures, reference adde
Retention in care and factors critical for effectively implementing antiretroviral adherence clubs in a rural district in South Africa
CITATION: Bock, P., et al. 2019. Retention in care and factors critical for effectively implementing antiretroviral adherence clubs in a rural district in South Africa. Journal of the International AIDS Society, 22(10):e25396, doi:10.1002/jia2.25396.The original publication is available at https://onlinelibrary.wiley.comPublication of this article was funded by the Stellenbosch University Open Access FundIntroduction: Differentiated models of care that include referral of antiretroviral treatment (ART) clients to adherence clubs
are an important strategy to help clinics manage increased number of clients living with HIV in resource-constrained settings.
This study reported on (i) clinical outcomes among ART clients attending community-based adherence clubs and (ii) experiences
of adherence clubs and perceptions of factors key to successful adherence club implementation among clients and
healthcare workers.
Methods: A retrospective cohort analysis of routine data and a descriptive analysis of data collected through self-administered
surveys completed by clients and healthcare workers were completed. Clients starting ART at the study clinic, between
January 2014 and December 2015, were included in the cohort analysis and followed up until December 2016. The survey
data were collected from August to September 2017. The primary outcome for the cohort analysis was a comparison of loss
to follow-up (LTFU) between clients staying in clinic care and those referred to adherence clubs. Survey data reported on client
experiences of and healthcare worker perceptions of adherence club care.
Results: Cohort analysis reported on 465 participants, median baseline CD4 count 374 (IQR: 234 to 532) cells/ll and median
follow-up time 20.7 (IQR 14.1 to 27.7) months. Overall, 202 (43.4%) participants were referred to an adherence club. LTFU
was lower in those attending an adherence club (aHR =0.25, 95% CI: 0.11 to 0.56). This finding was confirmed on analysis
restricted to those eligible for adherence club referral (aHR =0.28, 95% CI: 0.12 to 0.65). Factors highlighted as associated
with successful adherence club implementation included: (i) referral of stable clients to the club, (ii) an ideal club size of ≥20
members, (iii) club services led by a counsellor (iv) using churches or community halls as venues (v) effective communication
between all parties, and (vi) timely delivery of prepacked medication.
Conclusions: This study showed good clinical outcomes, positive patient experiences and healthcare worker perceptions of
the adherence club model. Factors associated with successful adherence club implementation, highlighted in this study, can be
used to guide implementers in the scale-up of adherence club services across varied high-burden settings.ns202011https://onlinelibrary.wiley.com/doi/full/10.1002/jia2.25396Publisher's versio
Attrition when providing antiretroviral treatment at CD4 counts >500cells/μL at three government clinics included in the HPTN 071 (PopART) trial in South Africa
CITATION: Bock, P., et al. 2018. Attrition when providing antiretroviral treatment at CD4 counts >500cells/μL at three government clinics included in the HPTN 071 (PopART) trial in South Africa. PLoS ONE, 13(4):e0195127, doi:10.1371/journal.pone.0195127.The original publication is available at https://journals.plos.org/plosone/Introduction: WHO recommends antiretroviral treatment (ART) for all HIV-positive individuals. This study evaluated the association between baseline CD4 count and attrition in a cohort of HIV positive adults initiating ART at three department of health (DOH) clinics routinely providing ART at baseline CD4 counts >500cells/μL for the HPTN 071 (PopART) trial.
Methods:
All clients attending the DOH clinics were managed according to standard care guidelines with the exception that those starting ART outside of pertinent local guidelines signed research informed consent. DOH data on all HIV-positive adult clients recorded as having initiated ART between January 2014 and November 2015 at the three study clinics was analysed. Attrition, included clients lost to follow up or died, and was defined as ‘being three or more months late for an antiretroviral pharmacy pick-up appointment’. All clients were followed until attrition, transfer out or end May 2016.
Results:
A total of 2423 clients with a median baseline CD4 count of 328 cells/μL (IQR 195–468) were included of whom 631 (26.0%) experienced attrition and 140 (5.8%) were TFO. Attrition was highest during the first six months of ART (IR 38.3/100 PY; 95% CI 34.8–42.1). Higher attrition was found amongst those with baseline CD4 counts > 500 cells/μL compared to those with baseline CD4 counts of 0–500 cells/μL (aHR 1.26, 95%CI 1.05 to 1.52) This finding was confirmed on subset analyses when restricted to individuals non-pregnant at baseline and when restricted to individuals with follow up of > 12months.
Conclusions:Attrition in this study was high, particularly during the first six months of treatment. Attrition was highest amongst clients starting ART at baseline CD4 counts > 500 cells/μL. Strategies to improve retention amongst ART clients, particularly those starting ART at baseline CD4 counts >500cells/μL, need strengthening. Improved monitoring of clients moving in and out of ART care and between clinics will assist in better understanding attrition and ART coverage in high burden countries.https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0195127Publisher's versio
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A LOFAR observation of ionospheric scintillation from two simultaneous travelling ionospheric disturbances
This paper presents the results from one of the first observations of ionospheric scintillation taken using the Low-Frequency Array (LOFAR). The observation was of the strong natural radio source Cassiopeia A, taken overnight on 18–19 August 2013, and exhibited moderately strong scattering effects in dynamic spectra of intensity received across an observing bandwidth of 10–80 MHz. Delay-Doppler spectra (the 2-D FFT of the dynamic spectrum) from the first hour of observation showed two discrete parabolic arcs, one with a steep curvature and the other shallow, which can be used to provide estimates of the distance to, and velocity of, the scattering plasma. A cross-correlation analysis of data received by the dense array of stations in the LOFAR “core” reveals two different velocities in the scintillation pattern: a primary velocity of ~20–40 ms−1 with a north-west to south-east direction, associated with the steep parabolic arc and a scattering altitude in the F-region or higher, and a secondary velocity of ~110 ms−1 with a north-east to south-west direction, associated with the shallow arc and a scattering altitude in the D-region. Geomagnetic activity was low in the mid-latitudes at the time, but a weak sub-storm at high latitudes reached its peak at the start of the observation. An analysis of Global Navigation Satellite Systems (GNSS) and ionosonde data from the time reveals a larger-scale travelling ionospheric disturbance (TID), possibly the result of the high-latitude activity, travelling in the north-west to south-east direction, and, simultaneously, a smaller-scale TID travelling in a north-east to south-west direction, which could be associated with atmospheric gravity wave activity. The LOFAR observation shows scattering from both TIDs, at different altitudes and propagating in different directions. To the best of our knowledge this is the first time that such a phenomenon has been reported
Biallelic loss-of-function variants in PLD1 cause congenital right-sided cardiac valve defects and neonatal cardiomyopathy
Congenital heart disease is the most common type of birth defect, accounting for one-third of all congenital anomalies. Using whole-exome sequencing of 2718 patients with congenital heart disease and a search in GeneMatcher, we identified 30 patients from 21 unrelated families of different ancestries with biallelic phospholipase D1 (PLD1) variants who presented predominantly with congenital cardiac valve defects. We also associated recessive PLD1 variants with isolated neonatal cardiomyopathy. Furthermore, we established that p.I668F is a founder variant among Ashkenazi Jews (allele frequency of ~2%) and describe the phenotypic spectrum of PLD1-associated congenital heart defects. PLD1 missense variants were overrepresented in regions of the protein critical for catalytic activity, and, correspondingly, we observed a strong reduction in enzymatic activity for most of the mutant proteins in an enzymatic assay. Finally, we demonstrate that PLD1 inhibition decreased endothelial-mesenchymal transition, an established pivotal early step in valvulogenesis. In conclusion, our study provides a more detailed understanding of disease mechanisms and phenotypic expression associated with PLD1 loss of function
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