The spatial distribution of O-B5 stars in the solar neighborhood as measured by Hipparcos

We have developed a method to calculate the fundamental parameters of the vertical structure of the Galaxy in the solar neighborhood from trigonometric parallaxes alone. The method takes into account Lutz-Kelker-type biases in a self-consistent way and has been applied to a sample of O-B5 stars obtained from the Hipparcos catalog. We find that the Sun is located 24.2 +/- 1.7 (random) +/- 0.4 (systematic) pc above the galactic plane and that the disk O-B5 stellar population is distributed with a scale height of 34.2 +/- 0.8 (random) +/- 2.5 (systematic) pc and an integrated surface density of (1.62 +/- 0.04 (random) +/- 0.14 (systematic)) 10^{-3} stars pc^{-2}. A halo component is also detected in the distribution and constitutes at least ~5% of the total O-B5 population. The O-B5 stellar population within ~100 pc of the Sun has an anomalous spatial distribution, with a less-than-average number density. This local disturbance is probably associated with the expansion of Gould's belt.Comment: 14 pages, 3 figures, to appear in the May 2001 issue of the Astronomical Journa

Optical Technologies for UV Remote Sensing Instruments

Over the last decade significant advances in technology have made possible development of instruments with substantially improved efficiency in the UV spectral region. In the area of optical coatings and materials, the importance of recent developments in chemical vapor deposited (CVD) silicon carbide (SiC) mirrors, SiC films, and multilayer coatings in the context of ultraviolet instrumentation design are discussed. For example, the development of chemically vapor deposited (CVD) silicon carbide (SiC) mirrors, with high ultraviolet (UV) reflectance and low scatter surfaces, provides the opportunity to extend higher spectral/spatial resolution capability into the 50-nm region. Optical coatings for normal incidence diffraction gratings are particularly important for the evolution of efficient extreme ultraviolet (EUV) spectrographs. SiC films are important for optimizing the spectrograph performance in the 90 nm spectral region. The performance evaluation of the flight optical components for the Solar Ultraviolet Measurements of Emitted Radiation (SUMER) instrument, a spectroscopic instrument to fly aboard the Solar and Heliospheric Observatory (SOHO) mission, designed to study dynamic processes, temperatures, and densities in the plasma of the upper atmosphere of the Sun in the wavelength range from 50 nm to 160 nm, is discussed. The optical components were evaluated for imaging and scatter in the UV. The performance evaluation of SOHO/CDS (Coronal Diagnostic Spectrometer) flight gratings tested for spectral resolution and scatter in the DGEF is reviewed and preliminary results on resolution and scatter testing of Space Telescope Imaging Spectrograph (STIS) technology development diffraction gratings are presented

Detection of a Corrugated Velocity Pattern in the Spiral Galaxy NGC 5427

Here we report the detection, in Halpha emission, of a radial corrugation in the velocity field of the spiral galaxy NGC 5427. The central velocity of the Halpha line displays coherent, wavy-like variations in the vicinity of the spiral arms. The spectra along three different arm segments show that the maximum amplitude of the sinusoidal line variations are displaced some 500 pc from the central part of the spiral arms. The peak blueshifted velocities appear some 500 pc upstream the arm, whereas the peak redshifted velocities are located some 500 pc downstream the arm. This kinematical behavior is similar to the one expected in a galactic bore generated by the interaction of a spiral density wave with a thick gaseous disk, as recently modeled by Martos & Cox (1998).Comment: Accepted for publication in Ap

Epidural Hematoma Following Cervical Spine Surgery.

STUDY DESIGN: A multicentered retrospective case series. OBJECTIVE: To determine the incidence and circumstances surrounding the development of a symptomatic postoperative epidural hematoma in the cervical spine. METHODS: Patients who underwent cervical spine surgery between January 1, 2005, and December 31, 2011, at 23 institutions were reviewed, and all patients who developed an epidural hematoma were identified. RESULTS: A total of 16 582 cervical spine surgeries were identified, and 15 patients developed a postoperative epidural hematoma, for a total incidence of 0.090%. Substantial variation between institutions was noted, with 11 sites reporting no epidural hematomas, and 1 site reporting an incidence of 0.76%. All patients initially presented with a neurologic deficit. Nine patients had complete resolution of the neurologic deficit after hematoma evacuation; however 2 of the 3 patients (66%) who had a delay in the diagnosis of the epidural hematoma had residual neurologic deficits compared to only 4 of the 12 patients (33%) who had no delay in the diagnosis or treatment (P = .53). Additionally, the patients who experienced a postoperative epidural hematoma did not experience any significant improvement in health-related quality-of-life metrics as a result of the index procedure at final follow-up evaluation. CONCLUSION: This is the largest series to date to analyze the incidence of an epidural hematoma following cervical spine surgery, and this study suggest that an epidural hematoma occurs in approximately 1 out of 1000 cervical spine surgeries. Prompt diagnosis and treatment may improve the chance of making a complete neurologic recovery, but patients who develop this complication do not show improvements in the health-related quality-of-life measurements

A high-resolution radio survey of the Vela supernova remnant

This paper presents a high-resolution radio continuum (843 MHz) survey of the Vela supernova remnant. The contrast between the structures in the central pulsar-powered nebula of the remnant and the synchrotron radiation shell allows the remnant to be identified morphologically as a member of the composite class. The data are the first of a composite remnant at spatial scales comparable with those available for the Cygnus Loop and the Crab Nebula, and make possible a comparison of radio, optical and soft X-ray emission from the resolved shell filaments. The survey, made with the Molonglo Observatory Synthesis Telescope, covers an area of 50 square degrees at a resolution of 43'' x 60'', while imaging structures on scales up to 30'.Comment: 18 pages, 7 jpg figures (version with ps figures at http://astro.berkeley.edu/~dbock/papers/); AJ, in pres

An X-ray Imaging Study of the Stellar Population in RCW49

We present the results of a high-resolution X-ray imaging study of the stellar population in the Galactic massive star-forming region RCW49 and its central OB association Westerlund 2. We obtained a 40 ks X-ray image of a 17'x17' field using the Chandra X-ray Observatory and deep NIR images using the Infrared Survey Facility in a concentric 8'3x8'3 region. We detected 468 X-ray sources and identified optical, NIR, and Spitzer Space Telescope MIR counterparts for 379 of them. The unprecedented spatial resolution and sensitivity of the X-ray image, enhanced by optical and infrared imaging data, yielded the following results: (1) The central OB association Westerlund 2 is resolved for the first time in the X-ray band. X-ray emission is detected from all spectroscopically-identified early-type stars in this region. (2) Most (86%) X-ray sources with optical or infrared identifications are cluster members in comparison with a control field in the Galactic Plane. (3) A loose constraint (2--5 kpc) for the distance to RCW49 is derived from the mean X-ray luminosity of T Tauri stars. (4) The cluster X-ray population consists of low-mass pre--main-sequence and early-type stars as obtained from X-ray and NIR photometry. About 30 new OB star candidates are identified. (5) We estimate a cluster radius of 6'--7' based on the X-ray surface number density profiles. (6) A large fraction (90%) of cluster members are identified individually using complimentary X-ray and MIR excess emission. (7) The brightest five X-ray sources, two Wolf-Rayet stars and three O stars, have hard thermal spectra.Comment: 19 pages, 17 figures, 4 tables. ApJ in pres

The Vertical Structure of the Outer Milky Way HI Disk

We examine the outer Galactic HI disk for deviations from the b=0 plane by constructing maps of disk surface density, mean height, and thickness. We find that the Galactic warp is well described by a vertical offset plus two Fourier modes of frequency 1 and 2, all of which grow with Galactocentric radius. Adding the m=2 mode accounts for the large asymmetry between the northern and southern warps. We use a Morlet wavelet transform to investigate the spatial and frequency localization of higher frequency modes; these modes are often referred to as "scalloping." We find that the m=10 and 15 scalloping modes are well above the noise, but localized; this suggests that the scalloping does not pervade the whole disk, but only local regions.Comment: Accepted by ApJ. 17 pages, 18 figures. Color maps are available at http://astron.berkeley.edu/~elevin

Mucin pattern reflects the origin of the adenocarcinoma in Barrett's esophagus: a retrospective clinical and laboratorial study

<p>Abstract</p> <p>Background</p> <p>Mucin immunoexpression in adenocarcinoma arising in Barrett's esophagus (BE) may indicate the carcinogenesis pathway. The aim of this study was to evaluate resected specimens of adenocarcinoma in BE for the pattern of mucins and to correlate to the histologic classification.</p> <p>Methods</p> <p>Specimens were retrospectively collected from thirteen patients who underwent esophageal resection due to adenocarcinoma in BE. Sections were scored for the grade of intestinal metaplasia. The tissues were examined by immunohistochemistry for MUC2 and MUC5AC antibodies.</p> <p>Results</p> <p>Eleven patients were men. The mean age was 61 years old (varied from 40 to 75 years old). The tumor size had a mean of 4.7 ± 2.3 cm, and the extension of BE had a mean of 7.7 ± 1.5 cm. Specialized epithelium with intestinal metaplasia was present in all adjacent mucosas. Immunohistochemistry for MUC2 showed immunoreactivity in goblet cells, while MUC5AC was extensively expressed in the columnar gastric cells, localizing to the surface epithelium and extending to a variable degree into the glandular structures in BE. Tumors were classified according to the mucins in gastric type in 7/13 (MUC5AC positive) and intestinal type in 4/13 (MUC2 positive). Two tumors did not express MUC2 or MUC5AC proteins. The pattern of mucin predominantly expressed in the adjacent epithelium was associated to the mucin expression profile in the tumors, p = 0.047.</p> <p>Conclusion</p> <p>Barrett's esophagus adenocarcinoma shows either gastric or intestinal type pattern of mucin expression. The two types of tumors developed in Barrett's esophagus may reflect the original cell type involved in the malignant transformation.</p

New Herbig-Haro Objects and Giant Outflows in Orion

We present the results of a photographic and CCD imaging survey for Herbig-Haro (HH) objects in the L1630 and L1641 giant molecular clouds in Orion. The new HH flows were initially identified from a deep H-alpha film from the recently commissioned AAO/UKST H-alpha Survey of the southern sky. Our scanned H-alpha and broad band R images highlight both the improved resolution of the H-alpha survey and the excellent contrast of the H-alpha flux with respect to the broad band R. Comparative IVN survey images allow us to distinguish between emission and reflection nebulosity. Our CCD H-alpha, [SII], continuum and I band images confirm the presence of a parsec-scale HH flow associated with the Ori I-2 cometary globule and several parsec-scale strings of HH emission centred on the L1641-N infrared cluster. Several smaller outflows display one-sided jets. Our results indicate that for declinations south of -6 degrees in L1641, parsec-scale flows appear to be the major force in the large-scale movement of optical dust and molecular gas.Comment: 14 pages, Latex using MN style, 21 figures in JPEG format. Higher resolution figures available from S.L. Mader. Accepted by MNRAS. Email contact for higher resolution images: [email protected]

MUC4 mucin expression in human pancreatic tumours is affected by organ environment: the possible role of TGFβ2

MUC4 is highly expressed in human pancreatic tumours and pancreatic tumour cell lines, but is minimally or not expressed in normal pancreas or chronic pancreatitis. Here, we investigated the aberrant regulation of MUC4 expression in vivo using clonal human pancreatic tumour cells (CD18/HPAF) grown either orthotopically in the pancreas (OT) or ectopically in subcutaneous tissue (SC) in the nude mice. Histological examination of the OT and SC tumours showed moderately differentiated and anaplastic morphology, respectively. The OT tumour cells showed metastases to distant lymph nodes and faster tumour growth (