A malignus melanoma genetikai sokszínűsége és immunológiai jellemzői a terápiás paletta tükrében

Malignant melanoma, originating from pigment cells, is a highly aggressive tumour affecting patients of any age group. Its incidence is rapidly growing. The most common form can be easily diagnosed by any physician. There are some well-known genetic (skin-, eye-, hair colour, naevi, melanoma in the personal/family history) and environmental (ultraviolet radiation) predisposing factors. Treatment is based on early diagnosis and excision. When metastasis occurs, the traditional chemo- and radiotherapy gives a low response rate. Recently some newly approved targeted therapies and immunomodulant drugs have become available. This review focuses on the classification and novel therapeutic approaches of malignant melanoma to provide guidance to clinicians. Orv. Hetil., 2015, 156(15), 583-591

Viable Vocabularies: An Introduction to Controlling, Cleaning, and Linking Your Data

These slides are from an interactive workshop held at Hillman Library, University of Pittsburgh on March 23, 2018. Controlled vocabularies are lists of standardized words and phrases used to refer to ideas, physical characteristics, people, places, events, subject matter, and many other concepts. Using controlled vocabularies in projects and research allow for consistency and comparability, but getting started can seem like a bewildering process. In the first part of this workshop, we will cover finding, understanding, and using controlled vocabularies. Then, we will explore connecting terms to linked data vocabularies using OpenRefine

Modelling of Soil Organic Carbon Dynamics in Kazakhstan

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Kézművesipar Északkelet-Magyarországon (16-20. század) = Handicraft in North-East Hungary (16-20. Century)

A kutatási program végeredménye Északkelet-Magyarország 5 történeti vármegyéje (Abaúj, Borsod, Gömör, Torna és Zemplén) kézműves ipartörténetét bemutató kötet. A feldolgozás a kijelölt időhatárok ellenére a legkorábbi emlékekig visszanyúlva igyekszik átfogó, részletes képet szolgáltatni az egyes kézművesipari tevékenységi formákról a levéltárakban és múzeumokban fellelhető, döntően eddig feltáratlan források segítségével. Az iparágak múltját bemutató egységeket elemző tanulmányok bizonyítják, hogy évszázadokig Kassa volt a térség egyeduralkodó kézművesipari centruma. Hegemóniáját a 19. század elején Miskolc törte meg. A feldolgozás meggyőzően mutatja be a kézművesipar szerkezetében bekövetkezett változásokat is a területi átrendeződésekkel összhangban. | The result of the research programme is a book about the handicrafts' industrial history of the 5 historical counties in north-east Hungary (Gömör, Abaúj, Zemplén, Torna and Borsod). Dating back to the earliest records the processing tries, in despite of the assigned terms, to give a comprehensive and detailed picture of all the appearances of activities in the handicraft with the help of the still unexplored resources in archives and museums. The studies, which analyse the units showing the history of the manufactures, proof, that Kosice was the autocratic centre of the area's handicraft for centuries. Its hegemony ended in the beginning of the 19th century in Miskolc. The processing also convincingly shows the changes, which have occurred in the structure of the handicraft in accordance with the regional re-arrange

The norepinephrine transporter (NET) radioligand (S,S)-[18F]FMeNER-D2 shows significant decreases in NET density in the human brain in Alzheimer’s disease: a post-mortem autoradiographic study.

Earlier post-mortem histological and autoradiographic studies have indicated a reduction of cell numbers in the locus coeruleus (LC) and a corresponding decrease in norepinephrine transporter (NET) in brains obtained from Alzheimer's disease (AD) patients as compared to age-matched healthy controls. In order to test the hypothesis that the regional decrease of NET is a disease specific biomarker in AD and as such, it can be used in PET imaging studies for diagnostic considerations, regional differences in the density of NET in various anatomical structures were measured in whole hemisphere human brain slices obtained from AD patients and age-matched control subjects in a series of autoradiographic experiments using the novel selective PET radioligand for NET (S,S)-[F-18]FMeNER-D-2. (S,S)-[F-18]FMeNER-D-2 appears to be a useful imaging biomarker for quantifying the density of NET in various brain structures, including the LC and the thalamus wherein the highest densities are found in physiological conditions. In AD significant decreases of NET densities can be demonstrated with the radioligand in both structures as compared to age-matched controls. The decreases in AD correlate with the progress of the disease as indicated by Braak grades. As the size of the LC is below the spatial resolution of the PET scanners, but the size of the thalamus can be detected with appropriate spatial accuracy in advanced scanners, the present findings confirm our earlier observations with PET that the in vivo imaging of NET with (S,S)-[F-18]FMeNER-D-2 in the thalamus is viable. Nevertheless, further studies are warranted to assess the usefulness of such an imaging approach for the early detection of changes in thalamic NET densities as a disease-specific biomarker and the possible use of (S,S)-[F-18]FMeNER-D-2 as a molecular imaging biomarker in AD. (c) 2010 Elsevier Ltd. All rights reserved

Rebranding Originality for the Age of AI

Originality has been a longstanding focal point within the college classroom, with students being encouraged to embrace creativity and boldness. The traditional view of originality, relying solely on one\u27s wit and imagination, has lost its effectiveness in the present era. The concept of learning has undergone a significant transformation, no longer resembling the isolated ivory tower of the past where individuals would immerse themselves in books, hoping to be inspired. Instead, modern learning has become more social and collaborative. Students compare and contrast class material with online resources, engaging in conversations, both in person and virtually, to solidify their understanding. The author of the presentation contends that the future of higher education lies in collaborative originality. Collaboration goes beyond the mere sharing of ideas; it serves as a means of generating innovative concepts, thriving in the dissolution of traditional boundaries. The delineation between humans and machines, disciplines, and formal and informal learning has become increasingly blurred. In this context, modern originality emerges as a collaborative and interdisciplinary process. The advent of AI, notably exemplified by technologies like ChatGPT and Hyperwrite, has further accelerated this trend. Utilizing prompt engineering, individuals can seamlessly collaborate with virtual assistants to foster new ideas, revolutionizing the conventional notion of originality

Environmental assistance for small businesses: Best practices for maximization of small business participation in state funded environmental compliance programs

Small businesses face many challenges as they strive toward growth and profitability. Adding to this challenge is the demand for improved environmental performance. Pollution prevention is often the most cost effective way to improve environmental performance. Yet, small firms often lack the expertise they need to pursue pollution prevention opportunities. There are a number of state agencies in New York that provide assistance and funding to small businesses to implement pollution prevention strategies. They often work in collaboration with nonprofit organizations that provide on-site technical assistance and consultancy to small businesses. It is up to the small business management to decide whether they want to get involved in these programs. This thesis explores how the state grants are being used by small businesses to adopt pollution prevention practices and technologies, and what are the major criteria that influence small business management\u27s decision to voluntarily participate in these state funded projects

A color in situ hybridization method with improved sensitivity for the detection of low-abundance mRNAs

We have modified a nonradioactive (color) in situ hybridization method for the detection of mRNA populations, transcribed from the calmodulin (CaM) I gene, that exist in low abundances in tissues such as the white matter of the rat spinal cord. Our results indicate that increasing the pH of the hybridization solution from neutral to slightly alkaline (pH 8.0-8.5) drastically improves the detectable signal intensity of the digoxigenin-labeled CaM I gene-specific riboprobe while providing high spatial resolution. This method could be useful for the detection of other mRNA populations present in cells in low concentrations or in tissues where probe penetration might be impaired (e.g. a high lipid content)