SUCCESSFUL TREATMENT OF A PARAHISIAN WOLFF-PARKINSON-WHITE CASE WITH CRYOABLATION

A 27-year-old patient with Parahisian Wolff-Parkinson-White Syndrome (WPW), who had very frequent tachycardia attacks and pre-syncope complaints, could not be cured with the RF ablation method previously. Since RF ablation may necessitate a permanent cardiac pacemaker, cryoablation was decided to be performed in another session. Herein, we report a successful treatment of a WPW case via cryoablation

A case of coronary microfistula: A newborn microfistula

AbstractCoronary artery fistula is an abnormal connection between a coronary artery and a cardiac chamber, a great artery or the vena cava. Although coronary artery fistulas are known to be congenital malformations they might occur due to infection, trauma or may be iatrogenic. We present a case with acquired coronary microfistula, without any history of interventional procedure

Effect of preparation parameters on the performance of conductive composite gas separation membranes

Mixed matrix composite membranes of a conducting polymer, polypyrrole (PPy), and an insulating polymer, polybisphenol-A-carbonate (PC) were prepared by a combined in-situ polymerization and solvent evaporation. Mixed matrix composite membranes were synthesized to combine the good gas transport properties of conductive polymer, PPy, with good mechanical properties of PC

The Relationship between Grade of Ischemia, Success of Reperfusion, and Type of Thrombolytic Regimen

Background: This study was aimed to determine whether the grade of ischemia can predict the success of reperfusion in patients treated with thrombolytic therapy (TT) for ST elevation myocardial infarction (STEMI)

Zależność między stężeniem witaminy B12 a oceną w skali SYNTAX

Background: Vitamin B12 is required in the metabolism of homocysteine. Vitamin B12 deficiency has been implicated in endothelial dysfunction and cardiovascular disease via hyperhomocysteinaemia. However, the association of vitamin B12 and the severity of coronary artery disease has not been studied to date.   Aim: This study was conducted with the aim of evaluating the relationship between vitamin B12 and SYNTAX score.   Methods: Medical records of consecutive patients who underwent coronary artery bypass grafting surgery were retrospectively reviewed. The study group consisted of 127 patients. Vitamin B12, other biochemical parameters, clinical and echocardiographic parameters, and SYNTAX score were evaluated for all patients.   Results: Patients with vitamin B12 deficiency had a higher prevalence of cardiovascular risk factors such as diabetes mellitus, and history of transient ischaemic attack/stroke and heart failure. The SYNTAX score was significantly higher in patients with vitamin B12 deficiency (29.2 ± 4.9 vs. 22.5 ± 4.5, p < 0.05).   Conclusions: In our study, we found a significant relationship between vitamin B12 deficiency and SYNTAX score, demon­strating the severity and complexity of coronary artery disease.   Wstęp: Witamina B12 jest potrzebna do metabolizowania homocysteiny. Jej niedobór wiąże się z dysfunkcją śródbłonka i chorobami układu sercowo-naczyniowego poprzez hiperhomocysteinemię. Jednak dotychczas nie zbadano związku stężenia witaminy B12 ze stopniem ciężkości choroby wieńcowej.   Cel: Celem niniejszego badania była ocena zależności między stężeniem witaminy B12 a oceną w skali SYNTAX.   Metody: Przeprowadzono retrospektywną analizę danych medycznych chorych poddanych zabiegowi pomostowania aortalno-wieńcowego. Badana grupa liczyła 127 osób. U wszystkich pacjentów oceniano stężenie witaminy B12, inne parametry biochemiczne, objawy kliniczne, parametry echokardiograficzne oraz liczbę punktów wg skali SYNTAX.   Wyniki: U chorych z niedoborem witaminy B12 częściej występowały czynniki ryzyka sercowo-naczyniowego, takie jak cukrzyca, przebyte przemijające niedokrwienie mózgu/przebyty udar, niewydolność serca. Liczba punktów wg skali SYNTAX była istotnie większa u pacjentów z niedoborem witaminy B12 (29,2 ± 4,9 vs. 22,5 ± 4,5; p < 0,05).   Wnioski: W badaniu stwierdzono istotną zależność między niedoborem witaminy B12 a oceną w skali SYNTAX odzwierciedlającą stopień ciężkości i złożoność choroby wieńcowej.  

The CHADS-VASc score is a predictor of no-reflow in patients with non-ST-segment elevation myocardial infarction

This study was performed to evaluate the relationship between the CHA(2)DS(2)-VASc score and no-reflow (NR) phenomena in patients with non-ST-segment elevation myocardial infarction (NSTEMI). A total number of 428 consecutive patients with NSTEMI were assessed for this study. Patients were divided into 2 groups, those with NR, NR(+) (n=84), and those without NR, NR(-) (n=307), according to their post-PCI, no-reflow status. The CHA(2)DS(2)-VASc score was significantly higher in the NR(+) group compared to the NR(-) (3.48 +/- 1.19 vs 1.81 +/- 0.82,P< 0.001). After a multivariate regression analysis, a higher CHA(2)DS(2)-VASc score (OR: 6.52, 95% CI: 3.51-12.14,P< 0.001), hs-Troponin (OR: 1.077, 95% CI: 1.056-1.099,P<0.001) and TTG (OR: 1.563, 95% CI: 1.134-2.154,P=0.006) were independent predictors of NR. CHA(2)DS(2)-VASc score is associated with higher risk of no-reflow in patients with NSTEMI undergoing PCI

Clinical and subclinical acute kidney injury in children with mild-to-moderate COVID-19

Background Our aim was to identify acute kidney injury (AKI) and subacute kidney injury using both KDIGO criteria and urinary biomarkers in children with mild/moderate COVID-19. Methods This cross-sectional study included 71 children who were hospitalized with a diagnosis of COVID-19 from 3 centers in Istanbul and 75 healthy children. We used a combination of functional (serum creatinine) and damage (NGAL, KIM-1, and IL-18) markers for the definition of AKI and subclinical AKI. Clinical and laboratory features were evaluated as predictors of AKI and subclinical AKI. Results Patients had significantly higher levels of urinary biomarkers and urine albumin-creatinine ratio than healthy controls (p < 0.001). Twelve patients (16.9%) developed AKI based on KDIGO criteria, and 22 patients (31%) had subclinical AKI. AKI group had significantly higher values of neutrophil count on admission than both subclinical AKI and non-AKI groups (p < 0.05 for all). Neutrophil count was independently associated with the presence of AKI (p = 0.014). Conclusions This study reveals that even children with a mild or moderate disease course are at risk for AKI. Association between neutrophil count and AKI may point out the role of inflammation in the development of AKI. Impact The key message of our article is that not only children with severe disease but also children with mild or moderate disease have an increased risk for kidney injury due to COVID-19. Urinary biomarkers enable the diagnosis of a significant number of patients with subclinical AKI in patients without elevation in serum creatinine. Our findings reveal that patients with high neutrophil count may be more prone to develop AKI and should be followed up carefully. We conclude that even children with mild or moderate COVID-19 disease courses should be evaluated for AKI and subclinical AKI, which may improve patient outcomes