22 research outputs found

    Method for determining the characteristics of a gas-steam chp with a steam turbo drive of a compressor

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    A new type of maneuverable combined-cycle plant with a steam-turbine drive of a low-pressure compressor is considered. The analysis of its technological processes in the generation of electric and thermal energy in heating and non-heating periods of the year is carried out. It is shown that in heating conditions, the burning of additional fuel in the afterburner between the stages of the evaporator of the utilizer boiler provides an increase in its steam production, maneuverability, thermal and electric power of the CCGT-CHP plant. The influence of the chemical composition and thermophysical properties of natural gas on obtaining the required excess air in the combustion chamber of a combined cycle gas turbine is considered. A mathematical model of technological processes is developed. The influence of deep utilization of the heat of the flue gases of the utilizer boiler on increasing the efficiency and improving the environmental characteristics of the gas-steam plant of a thermal power plant was recorded. © 2020 Institute of Physics Publishing. All rights reserved

    Immunomodulatory Activity of Polysaccharides Isolated from <i>Saussurea salicifolia</i> L. and <i>Saussurea frolovii</i> Ledeb

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    The genus Saussurea has been used in the preparation of therapies for a number of medical problems, yet not much is known about the therapeutic high-molecular-weight compounds present in extracts from these plants. Since polysaccharides are important in immune modulation, we investigated the chemical composition and immunomodulatory activity of Saussurea salicifolia L. and Saussurea frolovii Ledeb polysaccharides. Water-soluble polysaccharides from the aerial parts of these plants were extracted using water at pHs of 2 and 6 and subsequently precipitated in ethanol to obtain fractions SSP2 and SSP6 from S. salicifolia and fractions SSF2 and SSF6 from S. frolovii. The molecular weights of fractions SSP2, SSP6, SFP2, and SFP6 were estimated to be 143.7, 113.2, 75.3, and 64.3 kDa, respectively. The polysaccharides from S. frolovii contained xylose (67.1–71.7%) and glucose (28.3–32.9%), whereas the polysaccharides from S. frolovii contained xylose (63.1–76.7%), glucose (11.8–19.2%), galactose (4.7–8.3%), and rhamnose (6.8–9.4%). Fractions SSP2, SSP6, and SFP2 stimulated nitric oxide (NO) production by murine macrophages, and NO production induced by SSP2, SSP6, and SFP2 was not inhibited by polymyxin B treatment of the fractions, whereaspolymyxin B treatment diminished the effects of SFP6, suggesting that SFP6 could contain lipopolysaccharide (LPS). The LPS-free fractions SSP2, SSP6, and SFP2 had potent immunomodulatory activity, induced NO production, and activated transcription factors NF-κB/AP-1 in human monocytic THP-1 cells and cytokine production by human MonoMac-6 monocytic cells, including interleukin (IL)-1α, IL-1β, IL-6, granulocyte macrophage colony-stimulating factor (GM-CSF), interferon-γ, monocyte chemotactic protein 1 (MCP-1), and tumor necrosis factor (TNF). These data suggest that at least part of the beneficial therapeutic effects reported for water extracts of the Saussurea species are due to the modulation of leukocyte functions by polysaccharides
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