Alien Registration- Guiou, George L. (Presque Isle, Aroostook County)

https://digitalmaine.com/alien_docs/33580/thumbnail.jp

Alien Registration- Guiou, Levi (Presque Isle, Aroostook County)

https://digitalmaine.com/alien_docs/33581/thumbnail.jp

Expianation of Stock Price Movements Using a Single Equation Non-linear Model

Business Administratio

Complexity and information technologies: an ethical inquiry into human autonomous action

In this article, we discuss, from a complex systems perspective, possible implications of the rising dependency between autonomous human social/individual action, ubiquitous computing, and artificial intelligent systems. Investigation is made of ethical and political issues related to the application of ubiquitous computing resources to autonomous decision-making processes and to the enhancement of human cognition and action. We claim that without the feedback of fellow humans, which teaches us the consequences of our actions in real everyday life, the indiscriminate use of ubiquitous computing in decision-making processes seems to be beyond the reach of any clear ethical control. We argue that the complex systems perspective may help us to foresee possible long-term consequences of our choices, in areas where human autonomous action can be directly affected by informational technologies

Novel Therapies in Glioblastoma

Conventional treatment of glioblastoma has advanced only incrementally in the last 30 years and still yields poor outcomes. The current strategy of surgery, radiation, and chemotherapy has increased median survival to approximately 15 months. With the advent of molecular biology and consequent improved understanding of basic tumor biology, targeted therapies have become cornerstones for cancer treatment. Many pathways (RTKs, PI3K/AKT/mTOR, angiogenesis, etc.) have been identified in GBM as playing major roles in tumorigenesis, treatment resistance, or natural history of disease. Despite the growing understanding of the complex networks regulating GBM tumors, many targeted therapies have fallen short of expectations. In this paper, we will discuss novel therapies and the successes and failures that have occurred. One clear message is that monotherapies yield minor results, likely due to functionally redundant pathways. A better understanding of underlying tumor biology may yield insights into optimal targeting strategies which could improve the overall therapeutic ratio of conventional treatments

Hábitos e racionalidade: um estudo filosófico-interdisciplinar sobre autonomia na era dos Big Data

(This article is part of a project by Trans/Form/Ação: Unesp Philosophy Journal. It is the Authorial Philosophy Dossier, to be published in 2022.) In this article, the following dilemma is discussed: On the one hand, the growing impact of Technology of communication and information (ICT) in everyday habits seems to influence the dynamics of public opinion by reinforcing irrational beliefs, and creating the impression that the autonomy of people’s opinion and decisions is just a myth. On the other hand, people seem to act most of the time, under the normal circumstances of daily life, in a rational way, as if their habitual actions result from relatively autonomous decisions. A way out of this dilemma is suggested with the hypothesis that people can be rational most of the time, but nevertheless have their opinions influenced by insufficient, distorted information, or by previously acquired emotional dispositions. This hypothesis, in turn, is going to be scrutinized by considering, from a philosophical-interdisciplinary perspective, the role of rational choices in the dynamics of autonomous opinion. With illustrations of diagrams, we claim that the qualitative Complex Systems paradigm might help us to understand the possible role of emotional dispositions in the dynamics of autonomous opinion formation.(Este artigo faz parte de um projeto da Trans/Form/Ação: revista de filosofia da Unesp. Trata-se do Dossiê Filosofia Autoral, a ser publicado em 2022.) Neste artigo, discutimos o seguinte dilema: de um lado, o crescente impacto das Tecnologias de Comunicação e Informação nos hábitos cotidianos parece influenciar a dinâmica da opinião pública, reforçando crenças irracionais e criando a impressão de que a autonomia da opinião e das decisões das pessoas é apenas um mito. De outro lado, as pessoas parecem agir racionalmente na maioria das vezes, nas circunstâncias normais da vida cotidiana, como se suas ações habituais resultassem de decisões relativamente autônomas. A hipótese que propomos para superar o dilema é de que as pessoas podem agir racionalmente na maioria das vezes, mas têm suas opiniões influenciadas por informações insuficientes ou distorcidas ou por hábitos e disposições emocionais previamente adquiridas. Essa hipótese, por sua vez, será examinada, a partir de uma perspectiva filosófico-interdisciplinar, considerando o papel das escolhas racionais na dinâmica de formação da opinião autônoma. Com diagramas ilustrativos, argumentamos que hipóteses da teoria dos Sistemas Complexos podem auxiliar a compreensão do possível papel de disposições emocionais no processo de formação de opiniões

Hábitos e racionalidade: um estudo filosófico-interdisciplinar sobre autonomia na era dos big data

The following dilemma is discussed: On the one hand, the growing impact of Technology of communication and information (ICT) in everyday habits seems to influence the dynamics of public opinion by reinforcing irrational beliefs and creating the impression that the autonomy of people’s opinion and decisions is just a myth. On the other hand, people seem to act most of the time, under the normal circumstances of daily life, in a rational way, as if their habitual actions result from relatively autonomous decisions. A way out of this dilemma is suggested with the hypothesis that people can be rational most of the time, but nevertheless have their opinions influenced by insufficient, distorted information, or by previously acquired emotional dispositions. This hypothesis, in turn, is going to be scrutinized by considering, from a philosophical-interdisciplinary perspective, the role of rational choices in the dynamics of autonomous opinion. With illustrations of diagrams, we claim that the qualitative Complex Systems paradigm might help us to understand the possible role of emotional dispositions in the dynamics of autonomous opinion formation.Neste texto, discutimos o seguinte dilema: por um lado, o crescente impacto das Tecnologias de Comunicação e Informação nos hábitos cotidianos parece influenciar a dinâmica da opinião pública, reforçando crenças irracionais e criando a impressão de que a autonomia da opinião e das decisões das pessoas é apenas um mito. Por outro lado, as pessoas parecem agir racionalmente na maioria das vezes, nas circunstâncias normais da vida cotidiana, como se suas ações habituais resultassem de decisões relativamente autônomas. A hipótese que propomos para superar o dilema é de que as pessoas podem agir racionalmente na maioria das vezes, mas têm suas opiniões influenciadas por informações insuficientes ou distorcidas ou por hábitos e disposições emocionais previamente adquiridas. Essa hipótese, por sua vez, será examinada, a partir de uma perspectiva filosófico-interdisciplinar, considerando o papel das escolhas racionais na dinâmica de formação da opinião autônoma. Com diagramas ilustrativos, argumentamos que hipóteses da teoria dos Sistemas Complexos podem auxiliar a compreensão do possível papel de disposições emocionais no processo de formação de opiniões

Reduced responsiveness is an essential feature of chronic fatigue syndrome: A fMRI study

BACKGROUND: Although the neural mechanism of chronic fatigue syndrome has been investigated by a number of researchers, it remains poorly understood. METHODS: Using functional magnetic resonance imaging, we studied brain responsiveness in 6 male chronic fatigue syndrome patients and in 7 age-matched male healthy volunteers. Responsiveness of auditory cortices to transient, short-lived, noise reduction was measured while subjects performed a fatigue-inducing continual visual search task. RESULTS: Responsiveness of the task-dependent brain regions was decreased after the fatigue-inducing task in the normal and chronic fatigue syndrome subjects and the decrement of the responsiveness was equivalent between the 2 groups. In contrast, during the fatigue-inducing period, although responsiveness of auditory cortices remained constant in the normal subjects, it was attenuated in the chronic fatigue syndrome patients. In addition, the rate of this attenuation was positively correlated with the subjective sensation of fatigue as measured using a fatigue visual analogue scale, immediately before the magnetic resonance imaging session. CONCLUSION: Chronic fatigue syndrome may be characterised by attenuation of the responsiveness to stimuli not directly related to the fatigue-inducing task