411 research outputs found
A new approach to the joined estimation of the heat generated by a semicontiunuous emulsion polymerization Qr and the overall heat exchange parameter UA
Molecular Systematics of the Deep-Sea Hydrothermal Vent Endemic Brachyuran Family Bythograeidae: A Comparison of Three Bayesian Species Tree Methods
Brachyuran crabs of the family Bythograeidae are endemic to deep-sea hydrothermal vents and represent one of the most successful groups of macroinvertebrates that have colonized this extreme environment. Occurring worldwide, the family includes six genera (Allograea, Austinograea, Bythograea, Cyanagraea, Gandalfus, and Segonzacia) and fourteen formally described species. To investigate their evolutionary relationships, we conducted Maximum Likelihood and Bayesian molecular phylogenetic analyses, based on DNA sequences from fragments of three mitochondrial genes (16S rDNA, Cytochrome oxidase I, and Cytochrome b) and three nuclear genes (28S rDNA, the sodium–potassium ATPase a-subunit ‘NaK’, and Histone H3A). We employed traditional concatenated (i.e., supermatrix) phylogenetic methods, as well as three recently developed Bayesian multilocus methods aimed at inferring species trees from potentially discordant gene trees. We found strong support for two main clades within Bythograeidae: one comprising the members of the genus Bythograea; and the other comprising the remaining genera. Relationships within each of these two clades were partially resolved. We compare our results with an earlier hypothesis on the phylogenetic relationships among bythograeid genera based on morphology. We also discuss the biogeography of the family in the light of our results. Our species tree analyses reveal differences in how each of the three methods weighs conflicting phylogenetic signal from different gene partitions and how limits on the number of outgroup taxa may affect the results
Optimal Interpolation and Prediction in Pulsar Timing
For pulsar projects it is often necessary to predict the pulse phase in
advance, for example, when preparing for new observations. Interpolation of the
pulse phase between existing measurements is also often required, for example,
when folding X-ray or gamma-ray observations according to the radio pulse
phase. Until now these procedures have been done using various ad hoc methods.
The purpose of this paper is to show how to interpolate or predict the pulse
phase optimally using statistical models of the various noise processes and the
phase measurement uncertainty.Comment: 9 pages, accepted by MNRA
Measurement of radon-induced backgrounds in the NEXT double beta decay experiment
The measurement of the internal Rn activity in the NEXT-White
detector during the so-called Run-II period with Xe-depleted xenon is
discussed in detail, together with its implications for double beta decay
searches in NEXT. The activity is measured through the alpha production rate
induced in the fiducial volume by Rn and its alpha-emitting progeny.
The specific activity is measured to be ~mBq/m. Radon-induced electrons have also been
characterized from the decay of the Bi daughter ions plating out on the
cathode of the time projection chamber. From our studies, we conclude that
radon-induced backgrounds are sufficiently low to enable a successful NEXT-100
physics program, as the projected rate contribution should not exceed
0.1~counts/yr in the neutrinoless double beta decay sample.Comment: 28 pages, 10 figures, 6 tables. Version accepted for publication in
JHE
Repurposing anthelmintic agents to eradicate resistant leukemia
Despite rapid progress in genomic profiling in acute lymphoblastic leukemia (ALL), identification of actionable targets and prediction of response to drugs remains challenging. To identify specific vulnerabilities in ALL, we performed a drug screen using primary human ALL samples cultured in a model of the bone marrow microenvironment combined with high content image analysis. Among the 2487 FDA-approved compounds tested, anthelmintic agents of the class of macrocyclic lactones exhibited potent anti-leukemia activity, similar to the already known anti-leukemia agents currently used in induction chemotherapy. Ex vivo validation in 55 primary ALL samples of both precursor B cell and T-ALL including refractory relapse cases confirmed strong anti-leukemia activity with IC50 values in the low micromolar range. Anthelmintic agents increased intracellular chloride levels in primary leukemia cells, inducing mitochondrial outer membrane depolarization and cell death. Supporting the notion that simultaneously targeting cell death machineries at different angles may enhance the cell death response, combination of anthelmintic agents with the BCL-2 antagonist navitoclax or with the chemotherapeutic agent dexamethasone showed synergistic activity in primary ALL. These data reveal anti-leukemia activity of anthelmintic agents and support exploiting drug repurposing strategies to identify so far unrecognized anti-cancer agents with potential to eradicate even refractory leukemia
Radon and material radiopurity assessment for the NEXT double beta decay experiment
The Neutrino Experiment with a Xenon TPC (NEXT), intended to investigate the
neutrinoless double beta decay using a high-pressure xenon gas TPC filled with
Xe enriched in 136Xe at the Canfranc Underground Laboratory in Spain, requires
ultra-low background conditions demanding an exhaustive control of material
radiopurity and environmental radon levels. An extensive material screening
process is underway for several years based mainly on gamma-ray spectroscopy
using ultra-low background germanium detectors in Canfranc but also on mass
spectrometry techniques like GDMS and ICPMS. Components from shielding,
pressure vessel, electroluminescence and high voltage elements and energy and
tracking readout planes have been analyzed, helping in the final design of the
experiment and in the construction of the background model. The latest
measurements carried out will be presented and the implication on NEXT of their
results will be discussed. The commissioning of the NEW detector, as a first
step towards NEXT, has started in Canfranc; in-situ measurements of airborne
radon levels were taken there to optimize the system for radon mitigation and
will be shown too.Comment: Proceedings of the Low Radioactivity Techniques 2015 workshop
(LRT2015), Seattle, March 201
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