Morphinanes isomères originaux isolés de Stephania zippeliana

A côté de huit aporphinoïdes, six alcaloïdes possédant une structure de morphinane ont été isolés des parties aériennes de #Stephania zippeliana$ Miq. (Ménispermacées) : quatre d'entre eux sont nouveaux : la (+)-erromangine 2, la (+)-tannagine 3, la (+)-zippeline 5 et la (+)-zippelianine 6. La (+)-isostephodeline 4 et les composés 2 et 3 sont isomères. La structure de la (+)-isostephodeline 4 a été corrigée. (Résumé d'auteur

Cryogenic operation and testing of the extended LHC prototype magnet string

After the assembly, commissioning and successful first operation of a full-scale superconducting magnet string, and as a new prototype dipole magnet was added to approach final configuration, the cryogenic system has been slightly modified to allow the verification of the performance of the superfluid helium cooling loop in counter-current two-phase flow. At the same time the control system strategies have been updated and only two quench relief valves have been installed, one at each end of the string. We report on the cryogenic operation of the extended version of the string and the response of the system to transients

Exploiting the Bipartite Structure of Entity Grids for Document Coherence and Retrieval

International audienceDocument coherence describes how much sense text makes in terms of its logical organisation and discourse flow. Even though coherence is a relatively difficult notion to quantify precisely, it can be approximated automatically. This type of coherence modelling is not only interesting in itself, but also useful for a number of other text processing tasks, including Information Retrieval (IR), where adjusting the ranking of documents according to both their relevance and their coherence has been shown to increase retrieval effectiveness.The state of the art in unsupervised coherence modelling represents documents as bipartite graphs of sentences and discourse entities, and then projects these bipartite graphs into one–mode undirected graphs. However, one–mode projections may incur significant loss of the information present in the original bipartite structure. To address this we present three novel graph metrics that compute document coherence on the original bipartite graph of sentences and entities. Evaluation on standard settings shows that: (i) one of our coherence metrics beats the state of the art in terms of coherence accuracy; and (ii) all three of our coherence metrics improve retrieval effectiveness because, as closer analysis reveals, they capture aspects of document quality that go undetected by both keyword-based standard ranking and by spam filtering. This work contributes document coherence metrics that are theoretically principled, parameter-free, and useful to IR

The LHC test string: first operational experience

CERN operates the first version of the LHC Test String which consists of one quadrupole and three 10-m twin aperture dipole magnets. An experimental programme aiming at the validation of the LHC systems started in February 1995. During this programme the string has been powered 100 times 35 of which at 12.4 kA or above. The experiments have yielded a number of results some of which, like quench recovery for cryogenics, have modified the design of subsystems of LHC. Others, like controlled helium leaks in the cold bore and quench propagation bewteen magnets, have given a better understanding on the evolution of the phenomena inside a string of superconducting magnets cooled at superfluid helium temperatures. Following the experimental programme, the string will be powered up and powered down in one hour cycles as a fatigue test of the structure thus simulating 20 years of operation of LHC

Automated left ventricular diastolic function evaluation from phase-contrast cardiovascular magnetic resonance and comparison with Doppler echocardiography

International audienceBACKGROUND: Early detection of diastolic dysfunction is crucial for patients with incipient heart failure. Although this evaluation could be performed from phase-contrast (PC) cardiovascular magnetic resonance (CMR) data, its usefulness in clinical routine is not yet established, mainly because the interpretation of such data remains mostly based on manual post-processing. Accordingly, our goal was to develop a robust process to automatically estimate velocity and flow rate-related diastolic parameters from PC-CMR data and to test the consistency of these parameters against echocardiography as well as their ability to characterize left ventricular (LV) diastolic dysfunction. RESULTS: We studied 35 controls and 18 patients with severe aortic valve stenosis and preserved LV ejection fraction who had PC-CMR and Doppler echocardiography exams on the same day. PC-CMR mitral flow and myocardial velocity data were analyzed using custom software for semi-automated extraction of diastolic parameters. Inter-operator reproducibility of flow pattern segmentation and functional parameters was assessed on a sub-group of 30 subjects. The mean percentage of overlap between the transmitral flow segmentations performed by two independent operators was 99.7 ± 1.6%, resulting in a small variability ( 0.71) and receiver operating characteristic (ROC) analysis revealed their ability to separate patients from controls, with sensitivity > 0.80, specificity > 0.80 and accuracy > 0.85. Slight superiority in terms of correlation with echocardiography (r = 0.81) and accuracy to detect LV abnormalities (sensitivity > 0.83, specificity > 0.91 and accuracy > 0.89) was found for the PC-CMR flow-rate related parameters. CONCLUSIONS: A fast and reproducible technique for flow and myocardial PC-CMR data analysis was successfully used on controls and patients to extract consistent velocity-related diastolic parameters, as well as flow rate-related parameters. This technique provides a valuable addition to established CMR tools in the evaluation and the management of patients with diastolic dysfunction

Thaliporphine Preserves Cardiac Function of Endotoxemic Rabbits by Both Directly and Indirectly Attenuating NFκB Signaling Pathway

Cardiac depression in sepsis is associated with the increased morbidity and mortality. Although myofilaments damage, autonomic dysfunction, and apoptosis play roles in sepsis-induced myocardial dysfunction, the underlying mechanism is not clear. All of these possible factors are related to NFκB signaling, which plays the main role in sepsis signaling. Thaliporphine was determined to possess anti-inflammatory and cardioprotective activity by suppressing NFκB signaling in rodents. The purpose of this study is to further prove this protective effect in larger septic animals, and try to find the underlying mechanisms. The systolic and diastolic functions were evaluated in vivo by pressure-volume analysis at different preloads. Both preload-dependent and -independent hemodynamic parameters were performed. Inflammatory factors of whole blood and serum samples were analyzed. Several sepsis-related signaling pathways were also determined at protein level. Changes detected by conductance catheter showed Thaliporphine could recover impaired left ventricular systolic function after 4 hours LPS injection. It could also reverse the LPS induced steeper EDPVR and gentler ESPVR, thus improve Ees, Ea, and PRSW. Thaliporphine may exert this protective effect by decreasing TNFα and caspase3 dependent cell apoptosis, which was consistent with the decreased serum cTnI and LDH concentration. Thaliporphine could protect sepsis-associated myocardial dysfunction in both preload-dependent and -independent ways. It may exert these protective effects by both increase of “good”-PI3K/Akt/mTOR and decrease of “bad”-p38/NFκB pathways, which followed by diminishing TNFα and caspase3 dependent cell apoptosis