1,273 research outputs found

    Entrepreneurship and Firm Formation Across Countries

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    The World Bank Group Entrepreneurship Survey measures entrepreneurial activity around the world. The database includes cross-country, time-series data on the number of total and newly registered businesses for 84 countries. This paper finds significant relationships between entrepreneurial activity and indicators of economic and financial development and growth, the quality of the legal and regulatory environment, and governance. The analysis shows the importance of electronic registration procedures to encourage greater business registration. These results can guide effective policymaking and deliver new capabilities for identifying the impact of reforms

    Integrated Structure and Semantics for Reo Connectors and Petri Nets

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    In this paper, we present an integrated structural and behavioral model of Reo connectors and Petri nets, allowing a direct comparison of the two concurrency models. For this purpose, we introduce a notion of connectors which consist of a number of interconnected, user-defined primitives with fixed behavior. While the structure of connectors resembles hypergraphs, their semantics is given in terms of so-called port automata. We define both models in a categorical setting where composition operations can be elegantly defined and integrated. Specifically, we formalize structural gluings of connectors as pushouts, and joins of port automata as pullbacks. We then define a semantical functor from the connector to the port automata category which preserves this composition. We further show how to encode Reo connectors and Petri nets into this model and indicate applications to dynamic reconfigurations modeled using double pushout graph transformation

    Quantum kinetic Ising models

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    We introduce a quantum generalization of classical kinetic Ising models, described by a certain class of quantum many body master equations. Similarly to kinetic Ising models with detailed balance that are equivalent to certain Hamiltonian systems, our models reduce to a set of Hamiltonian systems determining the dynamics of the elements of the many body density matrix. The ground states of these Hamiltonians are well described by matrix product, or pair entangled projected states. We discuss critical properties of such Hamiltonians, as well as entanglement properties of their low energy states.Comment: 20 pages, 4 figures, minor improvements, accepted in New Journal of Physic

    Oral administration of the selective GPR120/FFA4 agonist compound A is not effective in alleviating tissue inflammation in mouse models of prototypical autoimmune diseases

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    ω3-polyunsaturated free fatty acids (ω3-PUFAs), particularly docosahexaenoic (DHA) and eicosapentaenoic acid (EPA), are thought to exert health promoting effects in metabolic and in inflammatory diseases. The molecular mechanisms of these beneficial effects are only partially understood. DHA and EPA activate Free Fatty Acid receptor 4 (GPR120/FFA4). Recently, the first orally available, synthetic ligand of FFA4, 3-[2-chloro-5-(trifluoromethoxy)phenyl]-3-azaspiro[5.5]undecane-9-acetic acid ("compound A"; cpd A) has been developed. Cpd A exhibits distinctly higher potency, efficiency, and selectivity at FFA4 than ω3-PUFAs and ameliorates insulin resistance and adipose tissue inflammation in the mouse. With GPR120/FFA4 activation believed to also attenuate tissue inflammation in autoimmune diseases, cpd A may also have a beneficial effect in these diseases. We have therefore addressed the therapeutic potential of cpd A in mouse models of three prototypical autoimmune diseases, specifically psoriasis, rheumatoid arthritis, and bullous pemphigoid. The effect of cpd A on the course of Aldara™-induced psoriasis-like dermatitis, K/BxN serum transfer arthritis, and antibody transfer pemphigoid disease-like dermatitis was scrutinized. Cpd A did not alter the course of Aldara-induced psoriasis-like dermatitis, K/BxN serum transfer arthritis, or antibody transfer pemphigoid disease-like dermatitis. Our results suggest that therapeutic regimens solely relying on FFA4 activation do not bear the potential to treat inflammatory diseases. With cpd A distinctly more potent in activating GPR120/FFA4 than ω3-PUFAs, this also suggests that GPR120/FFA4 activation by ω3-PUFAs does not significantly contribute to the health-promoting effects of ω3-PUFAs in autoimmune diseases

    Absence of static phase separation in the high-Tc cuprate YBa2Cu3O6+yYBa_{2}Cu_{3}O_{6+y}

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    We use 89Y NMR in YBa2Cu3O6+yYBa_{2}Cu_{3}O_{6+y} in order to evaluate with high sensitivity the distribution of hole content p in the CuO2 planes. For y=1 and y=0.6, this hole doping distribution is found narrow with a full width at half maximum smaller than Delta p=0.025. This rules out any large static phase separation between underdoped and optimally doped regions in contrast with the one observed by STM in Bi2212 and by NQR in LaSrCuO. This establishes that static electronic phase separation is not a generic feature of the cuprates.Comment: published in Phys.Rev.Lett. 89, 157002 (2002) (only minor changes as compared to previous version) Article of 4 pages + 3 figure

    Teleparallel Spin Connection

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    A new expression for the spin connection of teleparallel gravity is proposed, given by minus the contorsion tensor plus a zero connection. The corresponding minimal coupling is covariant under local Lorentz transformation, and equivalent to the minimal coupling prescription of general relativity. With this coupling prescription, therefore, teleparallel gravity turns out to be fully equivalent to general relativity, even in the presence of spinor fields.Comment: 2 pages, RevTeX, to appear in Phys. Rev D (Brief Report

    Barley β-glucan accelerates wound healing by favoring migration versus proliferation of human dermal fibroblasts

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    β-Glucans are considered candidates for the medication in different human pathologies. In this work, we have purified β-glucan from a selected barley line and tested their effects in primary human dermal fibroblasts. Unexpectedly, we have observed that this compound promoted a short-transitory proliferation arrest at 24 h after its addition on the medium. We have determined that this transitory arrest was dependent on the cell-cycle regulator protein Retinoblastoma. Moreover, dermal fibroblasts increase their migration capacities at 24 h after barley β-glucan addition. Also, we have described that barley β-glucan strongly reduced the ability of fibroblasts to attach and to spread on cell plates. Our data indicates that barley β-glucan signal induces an early response in HDF cells favoring migration versus proliferation. This feature is consistent with our observation that the topical addition of our barley β-glucan in vivo accelerates the wound closure in mouse skin

    Energy shortage failure prediction in photovoltaic standalone installations by using machine learning techniques

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    The use of energy storage systems in standalone photovoltaic installations is essential to supply energy demands, independently of solar generation. Accurate prediction of the battery state is critical for the safe, durable, and reliable operation of systems in this type of installations. In this study, an installation located in the area of Aragon (Spain) has been considered. Two methods, based on different types of Recurrent Neural Networks (RNN), are proposed to predict the battery voltage of the installation two days ahead. Specifically, the Nonlinear Auto Regressive with Exogenous Input (NARX) network and the Long Short-Term Memory (LSTM) network are studied and compared. The implemented algorithms process battery voltage, temperature and current waveforms; and rely on the selection of different future scenarios based on weather forecasting to estimate the future voltage of the battery. The proposed methodology is capable of predicting the voltage with a Root Mean Squared Error (RMSE) error of 1.2 V for batteries of 48 V, in critical situations where the installation is running out of energy. The study contributes to the ongoing research of developing preventive control systems that help reduce costs and improve the performance of remote energy storage systems based on renewable energies with a positive outcome
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