Synthesis of a Molecular Charm Bracelet via Click Cyclization and Olefin Metathesis Clipping

We describe the synthesis of a polycatenated cyclic polymer, a structure that resembles a molecular charm bracelet. Ruthenium-catalyzed ring-opening metathesis polymerization of an aminocontaining cyclic olefin monomer in the presence of a chain transfer agent generated an α,ω-diazide functionalized polyamine. Cyclization of the resulting linear polyamine using pseudo-high-dilution coppercatalyzed click cyclization produced a cyclic polymer in 19% yield. The click reaction was then further employed to remove linear contaminants from the cyclic polymer using azide- and alkyne-functionalized scavenging resins, and the purified cyclic polymer product was characterized by gel permeation chromatography, ^1H NMR spectroscopy, and IR spectroscopy. Polymer hydrogenation and conversion to the corresponding polyammonium species enabled coordination and interlocking of diolefin polyether fragments around the cyclic polymer backbone using ruthenium-catalyzed ring-closing olefin metathesis to afford a molecular charm bracelet structure. This charm bracelet complex was characterized by ^1H NMR spectroscopy, and the catenated nature of the small rings was confirmed using two-dimensional diffusion-ordered NMR spectroscopy

The Grizzly, October 16, 1997

Special Homecoming \u2797 Edition • The More Things Change • Extra, Extra! Breaking U.C. News From... • The Brief History of Ursinus • Remember When • Bears Take on The Bullets • Queens of the Past • And the Nominees are... • Famous Alumnihttps://digitalcommons.ursinus.edu/grizzlynews/1407/thumbnail.jp

Framing and visual type: Effect on future Zika vaccine uptake intent

Introduction: The Zika virus is associated with the birth defect microcephaly, and while a vaccine was not available in early- 2017, several were under development. This study’s purpose was to identify effective communication strategies to promote uptake of a new vaccine, particularly among women of reproductive age.Design and methods: In order to study the effects of Zika message framing (gain vs. loss) and visual type (photo vs. infographic) on future Zika vaccine uptake intent, a 2×2 between-subjects experiment was performed via an online survey in 2017 among 339 U.S. women of reproductive age (18-49 years). Participants were exposed to one of four messages, all resembling Instagram posts: gain-framed vs. loss-framed infographic, and gain-framed vs. loss-framed photo. These messages were followed by questions about Zika vaccine uptake intent as well as intermediate psychosocial variables that could lead to intent. Results: There was no interaction between framing and visual type (P=0.116), and there was no effect for framing (P=0.185) or visual type (P=0.724) on future Zika vaccine uptake intent, which is likely indicative of insufficient dosage of the intervention. However, when focusing on intermediate psychosocial constructs that are known to influence behavior and intent, gain-framed messages were more effective in increasing subjective norms (P=0.005) as related to a future Zika vaccine, as well as perceived benefits (P=0.016) and self-efficacy (P=0.032). Conclusions: Gain-framed messages seem to be more effective than loss-framed messages to increase several constructs that could, in turn, affect future Zika vaccine uptake intent. This is a novel finding since, traditionally, loss-framed messages are considered more beneficial in promoting vaccine-related health behaviors

The Grizzly, October 8, 1997

Teachers Honored • Gutwirth Lectures on Femininity • Job Help Available • Brecht on Brecht Performance • Students Harassed by Construction Workers • Opinion: Ursinus, Sometimes it Ursuckus • Another Successful Ursinus Family Day • Professors Perform Sweet Suite • Daneen on Brecht on Brecht • Kelly Foster Key to Field Hockey\u27s Success • XC Teams Fare Well at Messiah Invitational • Helpful Homecoming Hintshttps://digitalcommons.ursinus.edu/grizzlynews/1406/thumbnail.jp

The Grizzly, December 3, 1997

New Bookstore Anticipated Fall 1998 • Capano Charged with First Degree Murder • Opinion: Time to Procrastinate; Have Faith • Exam Schedule • Foreign Correspondence • Like Visiting an Old Friend • Soccer Seniors Reflect on Disappointing Seasonhttps://digitalcommons.ursinus.edu/grizzlynews/1411/thumbnail.jp

The Grizzly, November 19, 1997

British Nanny\u27s Sentence Reduced to Time Served • Lights, Camera, Incest! • Reimert Suite Beat • And the Show Went on • Exam Schedule • Dorm Improvements • Opinion: Help Yourself, Help Others; Ursinus Humanities Survive; Are Greeks Scapegoats?; Dry Spell; Don\u27t Complain, Do Something • Baseball Getting into the Swing of Things • Men\u27s Soccer Drops Final Game to Mules • Player Profile: Andrew Bauer; Chris Lakatoshhttps://digitalcommons.ursinus.edu/grizzlynews/1410/thumbnail.jp

The Lantern Vol. 65, No. 1, Fall 1997

• The Substitute • Style • The Greatest of These • The No-Zone • The Smell of Flowers • The Wine Cellar • Last Rites • The Missing Sock • In Loving Memory • New Jersey • Let\u27s Play a Game • Track Eleven • U Cab Chan Kina • Confined • Ekphrasis from Ursinus Campus in Snow • Five Elements • A Puzzle • Wh-?https://digitalcommons.ursinus.edu/lantern/1151/thumbnail.jp

The Grizzly, October 1, 1997

Berman Museum Exhibit Features Work of Sidney Quinn • Pfahler Renovations Continue • New Economics Faculty Introduced • Two Faculty Additions in English • Works From the New English Faculty • Opinion: Sculpture Cheesed; Conspiracy Theories, the Media, and Open-Minded Inquiry; A Quick Lesson in EcBa 100; The Things You Might Not Know About Ursinus • Domenick Scudera Directs proTheater\u27s Fall Production of Brecht on Brecht • Biloxi Blues: At Ease and in Top Form • Despite Shaky Start, Guenther\u27s Bears Optimistic • Women\u27s Soccer on a Roll • Men\u27s Soccer off to a Slow Starthttps://digitalcommons.ursinus.edu/grizzlynews/1405/thumbnail.jp

The Grizzly, November 5, 1997

Distinguished Alumni Return for Symposium • Ursinus Students and Faculty Attend Million Woman March • More Grants Received by Ursinus • Student\u27s Perseverance Rewarded • Test the Waters this Spring • Opinion: Faculty Responds to Curriculum Questions; Tired of Falling Asleep? • Stress Management • November Stress • Oedipus! Lives • There\u27s Something Brewing in The Java Trench • What\u27s with The Giant Green Gymnasium Anyway? • Ursinus: The Pseudo Liberal Arts College • Bears\u27 Swimmers Kick Back at Dickinson Relay Carnival • Men\u27s Soccer Continues to Struggle • Player Profiles: Jill Grau; Megan Larkinhttps://digitalcommons.ursinus.edu/grizzlynews/1409/thumbnail.jp

The Grizzly, October 29, 1997

Pennsylvania German Art Featured at Berman Art Museum • Pfahler Workers Dismissed • New Chaplain Introduced to Community • Commonwealth Brawl Raises Student Concern • Opinion: Award Winning My Ass; A Sweet Suite; Kudos to the College; Hail to the Queen; Leaving Home for Homecoming • Ghost Stories • Bears to Clash with Muhlenberg Mules • Men\u27s B-ball Gearing Up • Player Profiles: Lieberman, Steigerwalt Lead by Example; Mahoney a Constant Force for Young Women\u27s Teamhttps://digitalcommons.ursinus.edu/grizzlynews/1408/thumbnail.jp