Blood pressure distribution in microvascular networks

This paper was presented at the 2nd Micro and Nano Flows Conference (MNF2009), which was held at Brunel University, West London, UK. The conference was organised by Brunel University and supported by the Institution of Mechanical Engineers, IPEM, the Italian Union of Thermofluid dynamics, the Process Intensification Network, HEXAG - the Heat Exchange Action Group and the Institute of Mathematics and its Applications.Blood rheology is complex and nonlinear. The effective viscosity variations are important due to red blood cells packing inside capillaries, the socalled FåhræusLindquist effect, whilst concomitantly phase segregation appears in bifurcations. We have performed direct numerical simulations of different nonlinear rheological models of the blood on realistic threedimensional microvascular networks. These simulations point out two significant results. First, various rheological models lead to very similar pressure distributions over the whole range of physiologically relevant hematocrits. Secondly, different models for phase segregation lead to very distinct hematocrit distributions in the microvascular network. Moreover, for all the investigated rheological models, the hematocrit distribution very weakly affects the pressure distribution, when prescribing uniform pressure boundary conditions.The research was supported by GDR n° 2760 Biomécanique des fluides et des transferts Interaction fluide/structure biologique, the ASUPS A03 and A05 of Paul Sabatier University, Toulouse, France and the ANR project ANR06BLAN023801

The role of antibiotics in the treatment of chronic prostatitis: A consensus statement

Practical guidelines for the diagnosis and treatment of chronic prostatitis are presented. Chronic prostatitis is classified as chronic bacterial prostatitis (culture-positive) and chronic inflammatory prostatitis (culture-negative). If chronic bacterial prostatitis is suspected, based on relevant symptoms or recurrent UTIs, underlying urological conditions should be excluded by the following tests: rectal examination, midstream urine culture and residual urine. The diagnosis should be confirmed by the Meares and Stamey technique. Antibiotic therapy is recommended for acute exacerbations of chronic prostatitis, chronic bacterial prostatitis and chronic inflammatory prostatitis, if there is clinical, bacteriological or supporting immunological evidence of prostate infection. Unless a patient presents with fever, antibiotic treatment should not be initiated immediately except in cases of acute prostatitis or acute episodes in a patient with chronic bacterial prostatitis. The work-up, with the appropriate investigations should be done first, within a reasonable time period which, preferably, should not be longer than 1 week. During this period, nonspecific treatment, such as appropriate analgesia to relieve symptoms, should be given. The minimum duration of antibiotic treatment should be 2-4 weeks. If there is no improvement in symptoms, treatment should be stopped and reconsidered. However, if there is improvement, it should be continued for at least a further 2-4 weeks to achieve clinical cure and, hopefully, eradication of the causative pathogen. Antibiotic treatment should not be given for 6-8 weeks without an appraisal of its effectiveness. Currently used antibiotics are reviewed. Of these, the fluoroquinolones ofloxacin and ciprofloxacin are recommended because of their favourable antibacterial spectrum and pharmacokinetic profile. A number of clinical trials are recommended and a standard study design is proposed to help resolve some outstanding issues

Circulating microparticles from pulmonary hypertensive rats are vectors of oxidative stress

Date du colloque : 04/2010National audienc

Conjugate 18cm OH Satellite Lines at a Cosmological Distance

We have detected the two 18cm OH satellite lines from the $z \sim 0.247$ source PKS1413+135, the 1720 MHz line in emission and the 1612 MHz line in absorption. The 1720 MHz luminosity is $L_{\rm OH} \sim 354 L_\odot$, more than an order of magnitude larger than that of any other known 1720 MHz maser. The profiles of the two satellite lines are conjugate, implying that they arise in the same gas. This allows us to test for any changes in the values of fundamental constants, without being affected by systematic uncertainties arising from relative motions between the gas clouds in which the different lines arise. Our data constrain changes in $G \equiv g_p [\alpha^2/y]^{1.849}$, where $y \equiv m_e/m_p$; we find $\Delta G/G = 2.2 \pm 3.8 \times 10^{-5}$, consistent with no changes in $\alpha$, $g_p$ and $y$.Comment: 5 pages, 1 figure. Minor changes to match published versio

The Role of Pressure in GMC Formation II: The H_2 - Pressure Relation

We show that the ratio of molecular to atomic gas in galaxies is determined by hydrostatic pressure and that the relation between the two is nearly linear. The pressure relation is shown to be good over three orders of magnitude for 14 galaxies including dwarfs, HI-rich, and H_2-rich galaxies as well as the Milky Way. The sample spans a factor of five in mean metallicity. The rms scatter of individual points of the relation is only about a factor of two for all the galaxies, though some show much more scatter than others. Using these results, we propose a modified star formation prescription based on pressure determining the degree to which the ISM is molecular. The formulation is different in high and low pressure regimes defined by whether the gas is primarily atomic or primarily molecular. This formulation can be implemented in simulations and provides a more appropriate treatment of the outer regions of spiral galaxies and molecule-poor systems such as dwarf irregulars and damped Lyman-alpha systems.Comment: 14 pages, 7 figures, Accepted to the Astrophysical Journa

UX Usability Methods for Enterprise/Expert Systems

No abstract availabl

The Formaldehyde Masers in NGC 7538 and G29.96-0.02: VLBA, MERLIN, and VLA Observations

The 6 cm formaldehyde (H2CO) maser sources in the compact HII regions NGC 7538-IRS1 and G29.96-0.02 have been imaged at high resolution (beams < 50 mas). Using the VLBA and MERLIN, we find the angular sizes of the NGC 7538 masers to be ~10 mas (30 AU) corresponding to brightness temperatures ~10^8 K. The angular sizes of the G29.96-0.02 masers are ~20 mas (130 AU) corresponding to brightness temperatures ~10^7 K. Using the VLA, we detect 2 cm formaldehyde absorption from the maser regions. We detect no emission in the 2 cm line, indicating the lack of a 2 cm maser and placing limits on the 6 cm excitation process. We find that both NGC 7538 maser components show an increase in intensity on 5-10 year timescales while the G29.96-0.02 masers show no variability over 2 years. A search for polarization provides 3-sigma upper limits of 1% circularly polarized and 10% linearly polarized emission in NGC 7538 and of 15% circularly polarized emission in G29.96-0.02. A pronounced velocity gradient of 28 km/s/arcsecond (1900 km/s/pc) is detected in the NGC 7538 maser gas.Comment: accepted to ApJ, 15 figures, 11 table