Acrylic-melamine latex with controlled crosslinking capability

Crosslinkable polymers are highly demanded in applications where improved thermal, mechanical, and chemical strengths are required. Among crosslinkable polymers, those with film forming capability are of high technological interest, as in coatings and adhesives. In a scenario of increasing concern for sustainability and stricter environmental legislation, coatings industry has switched to water based products, like acrylic latexes. Crosslinkable latexes aim to improve the physical properties of coalesced latex films, over the levels attainable with thermoplastic latexes, which lack hardness, toughness and solvent resistance. Please click Additional Files below to see the full abstract

Film-forming thermoresponsive nanogels for dermal protein delivery

Thermoresponsive nanogels (NGs) have great potential as nanocarriers because of their high in aqueous solutions, elevated biocompatibility, high loading capacity, controlled release of an active component, fast response to temperature change, and design flexibility. In this scenario, a NG dispersion with a film forming ability could be useful for designing a dermal platform for drugs delivery, where the delivering film/patch could be previously obtained or directly formed onto the surface where the release is required. Please click Additional Files below to see the full abstract

Control of Molecular Weight Distribution in Emulsion Polymerization Using On-Line Reaction Calorimetry

The molecular weight distribution (MWD) of linear polymers was controlled based on on-line reaction calorimetry. A method to estimate the MWD from reaction calorimetry when chain transfer to a chain-transfer agent is the main termination event was developed and its robustness assessed by simulation. Following this method, the desired final MWD was decomposed in a series of instantaneous MWDs to be produced at different stages of the process. An optimization algorithm was used to calculate the set-point trajectories to produce the desired MWD in a minimum time. A nonlinear model based controller was used to track these trajectories. The control scheme was validated by preparing polystyrene latexes of widely different predefined MWD.Fil: Vicente, Matias. Universidad del País Vasco; EspañaFil: BenAmor, Selwa. Universidad del País Vasco; EspañaFil: Gugliotta, Luis Marcelino. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; ArgentinaFil: Leiza, Jose R.. Universidad del País Vasco; EspañaFil: Asua, Jose M.. Universidad del País Vasco; Españ

pH-Responsive casein-based films and their application as functional coatings in solid dosage formulations

Over the past few years, there has been increasing attention to the design of new drug delivery systems based on milk proteins due to their excellent functional properties. In this study, we report a new approach for preparing protein-based coating films using highly methacrylated casein as a macro-crosslinker. The films exhibited a smooth surface and an even casein distribution as evidenced by both scanning electron and atomic force microscopy, respectively. The mechanical behavior of the casein-based films could be easily tuned by controlling the degree of methacrylation of the bio-based crosslinker. The as-prepared films showed pH-dependent swelling, in which the swelling ability in alkaline medium was stronger than that at acid pH. The mechanical, swelling, rheological and release performance of the casein-based films suggest that these materials have a high potential as enteric coatings for intestinal drug delivery.Fil: Picchio, Matías Luis. Universidad Nacional de Córdoba. Instituto de Investigación y Desarrollo en Ingeniería de Procesos y Química Aplicada. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación y Desarrollo en Ingeniería de Procesos y Química Aplicada; Argentina. Universidad Tecnologica Nacional. Facultad Regional Villa Maria; ArgentinaFil: Paredes, Alejandro Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; ArgentinaFil: Palma, Santiago Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; ArgentinaFil: Passeggi, Mario Cesar Guillermo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Física del Litoral. Universidad Nacional del Litoral. Instituto de Física del Litoral; Argentina. Universidad Nacional del Litoral. Facultad de Ingeniería Química; ArgentinaFil: Gugliotta, Luis Marcelino. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina. Universidad Nacional del Litoral. Facultad de Ingeniería Química; ArgentinaFil: Minari, Roque Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina. Universidad Nacional del Litoral. Facultad de Ingeniería Química; ArgentinaFil: Alvarez Igarzabal, Cecilia Ines. Universidad Nacional de Córdoba. Instituto de Investigación y Desarrollo en Ingeniería de Procesos y Química Aplicada. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación y Desarrollo en Ingeniería de Procesos y Química Aplicada; Argentin