1,959 research outputs found
Sustainable gardens: an evaluation tool for management and planning strategies.
An evaluation tool was defined in order to manage gardens considering the six main directives of sustainability, from plant collections to public awareness and fruition
Morphological characterization, germination ecology and conservation of narrow endemic plant species of the Aeolian Islands (Sicily)
This stusy is focused on four narrow endemic species of the Aeolian fora: Anthemis aeolica, Erysimum brulloi, Cytisus aeolicus and Silene hicesiae. Morphological characterization of seeds, seed germination and dormancy regulation have been investigated for these species
Seed morphology and seed coat structure in Mediterranean plants: implication for evolution, taxonomy and germinative performance
A better understanding of morphological, ultra-structural and anatomical seed coat characteristics can contribute to explain and predict seed performance under certain environmental conditions and select the most suitable treatments promoting seed germination. The Seed Banks at the Botanic Gardens of Catania and Palermo (Sicily) are particularly involved in research studies aimed to detect and describe macro- and micro-morphological features of seeds from different plant families and genera, using both light and scanning electron microscopy. These studies mainly aim to 1) recognize and compare inter- and intra-specific variation of seed coat traits, with particular attention on rare and threatened species; 2) evaluate the usefulness of these traits in taxonomic and phylogenetic studies; 3) establish correlations between seed coat structures and seed germination; 4) understand the seed coat adaptive potential and sensitivity to particular ecological conditions and changing environments
Automated Experimental Modal Analysis of Bladed Wheels with an Anthropomorphic Robotic Station
Experimental modal analysis is challenging when the component has a highly three-dimensional shape, since a great number of measurement points are needed with accurate positioning. An anthropomorphic robotic station is proposed to automate this analysis, specifically on bladed wheels. This provides a reliable control of the spot location and of the beam orientation of a Laser Doppler Vibrometer. The modal frequencies were obtained along with the vibrational shapes and their spatial resolution was managed by exploiting the programming flexibility of the robotic station. The SAFE diagram was easily obtained by measuring a single point for each sector, and an extension of this diagram was demonstrated for the splitter blade wheels. The use of multiple measurement points, for each wheel sector, significantly improved the characterization of the modes having the same number of nodal diameters, hence the same shape coordinate on the SAFE diagram
Molecular dynamics simulations reveal the determinants of cyclin-dependent kinase 2 inhibition by 5-nitrosopyrimidine derivatives
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Nociceptin attenuates the escalation of oxycodone self-administration by normalizing CeA-GABA transmission in highly addicted rats.
Approximately 25% of patients who are prescribed opioids for chronic pain misuse them, and 5 to 10% develop an opioid use disorder. Although the neurobiological target of opioids is well known, the molecular mechanisms that are responsible for the development of addiction-like behaviors in some but not all individuals are poorly known. To address this issue, we used a unique outbred rat population (heterogeneous stock) that better models the behavioral and genetic diversity that is found in humans. We characterized individual differences in addiction-like behaviors using an addiction index that incorporates the key criteria of opioid use disorder: escalated intake, highly motivated responding, and hyperalgesia. Using in vitro electrophysiological recordings in the central nucleus of the amygdala (CeA), we found that rats with high addiction-like behaviors (HA) exhibited a significant increase in γ-aminobutyric acid (GABA) transmission compared with rats with low addiction-like behaviors (LA) and naive rats. The superfusion of CeA slices with nociceptin/orphanin FQ peptide (N/OFQ; 500 nM), an endogenous opioid-like peptide, normalized GABA transmission in HA rats. Intra-CeA levels of N/OFQ were lower in HA rats than in LA rats. Intra-CeA infusions of N/OFQ (1 μg per site) reversed the escalation of oxycodone self-administration in HA rats but not in LA rats. These results demonstrate that the downregulation of N/OFQ levels in the CeA may be responsible for hyper-GABAergic tone in the CeA that is observed in individuals who develop addiction-like behaviors. Based on these results, we hypothesize that small molecules that target the N/OFQ system might be useful for the treatment of opioid use disorder
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