Does human bocavirus infection depend on helper viruses? A challenging case report

A case of severe diarrhoea associated with synergistic human bocavirus type 1 (HBoV) and human herpes virus type 6 (HHV6) is reported. The case supports the hypotheses that HBoV infection under clinical conditions may depend on helper viruses, or that HBoV replicates by a mechanism that is atypical for parvoviruses, or that HBoV infection can be specifically treated with cidofovir

Quantum Shift Scheduling - A Comparison to Classical Approaches

Solving discrete optimization problems with constraints is a very common task in industry and research as it is fundamental in solving many planning tasks. In this paper we will look at an instance of a time table problem for generating shift schedules at the German Space Operation Center (GSOC). We describe the implementation of a quantum approach and compare the differences to classical optimization strategies, knowing that the problem sizes given to the quantum systems are not competitive yet. By doing so we are establishing a software chain that is able to map our problem to different physical systems which paves the way to problem solving as a hybrid solution where sub-problems are distributed among classical and quantum hardware. In this study we included three approaches to tackle the described problem. For the quantum part, we included a programmatically generated quantum circuit that yields a solution to a (sub) problem using Grovers algorithm, able to be run on any general quantum computer with sufficiently many qubits of sufficiently high quality. On the classical side, as a validation and benchmark reference, we use a heuristic search method, implemented by GSOCs own planning tool set Plato and PINTA (Lenzen et al. 2012; Nibler et al. 2021) as well as a constraint integer programming formulation solved by an external software framework, such as e. g. GLPK or SCIP (Gamrath et al. 2020). This paper builds on and extends results from (Scherer et al. 2021)

OnCall Operator Scheduling for Satellites with Grover's Algorithm

The application of quantum algorithms on some problems in NP promises a significant reduction of time complexity. This work uses Grover's Algorithm, designed to search an unstructured database with quadratic speedup, to find valid a solution for an instance of the on-call operator scheduling problem at the German Space Operation Center. We explore new approaches in encoding the problem and construct the Grover oracle automatically from the given constraints and independent of the problem size. Our solution is not designed for currently available quantum chips but aims to scale with their growth in the next years