International Research Symposium on Talent Education, Part 5: The challenges of offering group class

This is the fifth installment in a series of articles reporting on a large‐scale demographic survey of North American Suzuki teachers. The last article in this series examined some of the perceived benefits of group class. In this article, we will review participants’ perceptions of the challenges of group class. Participating teachers were asked to respond to the open‐ended question, "What is the greatest challenge of group class?" Their responses were coded and analyzed for important themes

International Research Symposium on Talent Education, Part 6: Parent education in Suzuki studios

This is the sixth installment in a series of articles reporting on a large‐scale demographic survey of North American Suzuki teachers. The previous article in this series examined some of the perceived challenges of group class. In this article, we will review teachers' descriptions of the parent education offerings within their studios. Teachers were asked to provide information about the structure, content, and intensity of their parent education programs. The survey questions included both initial education for new families entering their studios, as well as ongoing education for returning families

International Research Symposium on Talent Education, Part 4: The joys and benefits of Suzuki group class

This is the fourth article in a series reporting the findings of a large-scale demographic study of Suzuki teachers in Canada and the United States. Previous articles introduced the research, reporting on basic demographic statistics, teacher training, studio size, and structure of group classes. In this article we report on the results of an open-ended response question regarding the benefits of student participation in Suzuki group class

International Research Symposium on Talent Education, Part 3: What do Suzuki studios look like?

This is the third article in a series reporting the findings of a large-scale demographic study of 1128 North American SAA member teachers. The first article introduced the International Research Symposium on Talent Education and the group's current research interests. The second installment in the series focused on Suzuki teachers and included basic demographic information and information on teachers' training. In this article, we will explore what Suzuki studios look like, examining data such as studio size and structure of group classes

Complementary approaches to understanding the plant circadian clock

Circadian clocks are oscillatory genetic networks that help organisms adapt to the 24-hour day/night cycle. The clock of the green alga Ostreococcus tauri is the simplest plant clock discovered so far. Its many advantages as an experimental system facilitate the testing of computational predictions. We present a model of the Ostreococcus clock in the stochastic process algebra Bio-PEPA and exploit its mapping to different analysis techniques, such as ordinary differential equations, stochastic simulation algorithms and model-checking. The small number of molecules reported for this system tests the limits of the continuous approximation underlying differential equations. We investigate the difference between continuous-deterministic and discrete-stochastic approaches. Stochastic simulation and model-checking allow us to formulate new hypotheses on the system behaviour, such as the presence of self-sustained oscillations in single cells under constant light conditions. We investigate how to model the timing of dawn and dusk in the context of model-checking, which we use to compute how the probability distributions of key biochemical species change over time. These show that the relative variation in expression level is smallest at the time of peak expression, making peak time an optimal experimental phase marker. Building on these analyses, we use approaches from evolutionary systems biology to investigate how changes in the rate of mRNA degradation impacts the phase of a key protein likely to affect fitness. We explore how robust this circadian clock is towards such potential mutational changes in its underlying biochemistry. Our work shows that multiple approaches lead to a more complete understanding of the clock

Development and implementation of the AIDA International Registry for patients with Behçet’s disease

Purpose of the present paper is to point out the design, development and deployment of the AutoInflammatory Disease Alliance (AIDA) International Registry dedicated to pediatric and adult patients with Behçet’s disease (BD). The Registry is a clinical physician-driven non-population- and electronic-based instrument implemented for the retrospective and prospective collection of real-life data about demographics, clinical, therapeutic, laboratory, instrumental and socioeconomic information from BD patients; the Registry is based on the Research Electronic Data Capture (REDCap) tool, which is thought to collect standardised information for clinical real-life research, and has been realised to change over time according to future scientific acquisitions and potentially communicate with other existing and future Registries dedicated to BD. Starting from January 31st, 2021, to February 7th, 2022, 110 centres from 23 countries in 4 continents have been involved. Fifty-four of these have already obtained the approval from their local Ethics Committees. Currently, the platform counts 290 users (111 Principal Investigators, 175 Site Investigators, 2 Lead Investigators, and 2 data managers). The Registry collects baseline and follow-up data using 5993 fields organised into 16 instruments, including patient’s demographics, history, clinical manifestations and symptoms, trigger/risk factors, therapies and healthcare access. The development of the AIDA International Registry for BD patients will facilitate the collection of standardised data leading to real-world evidence, enabling international multicentre collaborative research through data sharing, international consultation, dissemination of knowledge, inclusion of patients and families, and ultimately optimisation of scientific efforts and implementation of standardised care. Trial registration NCT05200715 in 21/01/2022. © 2022, The Author(s)