Voice SourceWaveform Analysis and Synthesis Using Principal Component Analysis and Gaussian Mixture Modelling

The paper presents a voice source waveform modeling techniques based on principal component analysis (PCA) and Gaussian mixture modeling (GMM). The voice source is obtained by inverse-filtering speech with the estimated vocal tract filter. This decomposition is useful in speech analysis, synthesis, recognition and coding. Here, a data-driven approach is presented for signal decomposition and classification based on the principal components of the voice source. The principal components are analyzed and the 'prototype' voice source signals corresponding to the Gaussian mixture means are examined. We show how an unknown signal can be decomposed into its components and/or prototypes and resynthesized. We show how the techniques are suited for both low bitrate or high quality analysis/synthesis schemes

Migraine with aura and risk of cardiovascular and all cause mortality in men and women: prospective cohort study

Objective To estimate whether migraine in mid-life is associated with mortality from cardiovascular disease, other causes, and all causes

A Quantitative Assessment of Group Delay Methods for Identifying Glottal Closures in Voiced Speech

Abstract-Measures based on the group delay of the LPC residual have been used by a number of authors to identify the time instants of glottal closure in voiced speech. In this paper, we discuss the theoretical properties of three such measures and we also present a new measure having useful properties. We give a quantitative assessment of each measure's ability to detect glottal closure instants evaluated using a speech database that includes a direct measurement of glottal activity from a Laryngograph/EGG signal. We find that when using a fixed-length analysis window, the best measures can detect the instant of glottal closure in 97% of larynx cycles with a standard deviation of 0.6 ms and that in 9% of these cycles an additional excitation instant is found that normally corresponds to glottal opening. We show that some improvement in detection rate may be obtained if the analysis window length is adapted to the speech pitch. If the measures are applied to the preemphasized speech instead of to the LPC residual, we find that the timing accuracy worsens but the detection rate improves slightly. We assess the computational cost of evaluating the measures and we present new recursive algorithms that give a substantial reduction in computation in all cases

A Quantitative Assessment of Group Delay Methods for Identifying Glottal Closures in Voiced Speech

Abstract-Measures based on the group delay of the LPC residual have been used by a number of authors to identify the time instants of glottal closure in voiced speech. In this paper, we discuss the theoretical properties of three such measures and we also present a new measure having useful properties. We give a quantitative assessment of each measure's ability to detect glottal closure instants evaluated using a speech database that includes a direct measurement of glottal activity from a Laryngograph/EGG signal. We find that when using a fixed-length analysis window, the best measures can detect the instant of glottal closure in 97% of larynx cycles with a standard deviation of 0.6 ms and that in 9% of these cycles an additional excitation instant is found that normally corresponds to glottal opening. We show that some improvement in detection rate may be obtained if the analysis window length is adapted to the speech pitch. If the measures are applied to the preemphasized speech instead of to the LPC residual, we find that the timing accuracy worsens but the detection rate improves slightly. We assess the computational cost of evaluating the measures and we present new recursive algorithms that give a substantial reduction in computation in all cases

Polygenic overlap between C-reactive protein, plasma lipids, and Alzheimer disease

Background—Epidemiological findings suggest a relationship between Alzheimer disease (AD), inflammation, and dyslipidemia, although the nature of this relationship is not well understood. We investigated whether this phenotypic association arises from a shared genetic basis. Methods and Results—Using summary statistics (P values and odds ratios) from genome-wide association studies of >200 000 individuals, we investigated overlap in single-nucleotide polymorphisms associated with clinically diagnosed AD and C-reactive protein (CRP), triglycerides, and high- and low-density lipoprotein levels. We found up to 50-fold enrichment of AD single-nucleotide polymorphisms for different levels of association with C-reactive protein, low-density lipoprotein, high-density lipoprotein, and triglyceride single-nucleotide polymorphisms using a false discovery rate threshold <0.05. By conditioning on polymorphisms associated with the 4 phenotypes, we identified 55 loci associated with increased AD risk. We then conducted a meta-analysis of these 55 variants across 4 independent AD cohorts (total: n=29 054 AD cases and 114 824 healthy controls) and discovered 2 genome-wide significant variants on chromosome 4 (rs13113697; closest gene, HS3ST1; odds ratio=1.07; 95% confidence interval=1.05–1.11; P=2.86×10−8) and chromosome 10 (rs7920721; closest gene, ECHDC3; odds ratio=1.07; 95% confidence interval=1.04–1.11; P=3.38×10−8). We also found that gene expression of HS3ST1 and ECHDC3 was altered in AD brains compared with control brains. Conclusions—We demonstrate genetic overlap between AD, C-reactive protein, and plasma lipids. By conditioning on the genetic association with the cardiovascular phenotypes, we identify novel AD susceptibility loci, including 2 genome-wide significant variants conferring increased risk for AD.acceptedVersio