Observing The Mediterranean Sea from space: 21 years of Pathfinder-AVHRR Sea Surface Temperatures (1985 to 2005). Re-analysis and validation

International audienceThe time series of satellite infrared AVHRR data from 1985 to 2005 has been used to produce a daily series of optimally interpolated SST maps over the regular grid of the operational MFSTEP OGCM model of the Mediterranean basin. A complete validation of this OISST (Optimally Interpolated Sea Surface Temperature) product with in situ measurements has been performed in order to exclude any possibility of spurious trends due to instrumental calibration errors/shifts or algorithms malfunctioning related to local geophysical factors. The validation showed that satellite OISST is able to reproduce in situ measurements with a mean bias of less than 0.1°C and RMSE of about 0.5°C and that errors do not drift with time or with the percent interpolation error

Do seismic waves sense fracture connectivity?

A defining characteristic of fractured rocks is their very high level of seismic attenuation, which so far has been assumed to be mainly due to wave-induced fluid flow (WIFF) between the fractures and the pore space of the embedding matrix. Using oscillatory compressibility simulations based on the quasi-static poroelastic equations, we show that another important, and as of yet undocumented, manifestation of WIFF is at play in the presence of fracture connectivity. This additional energy loss is predominantly due to fluid flow within the connected fractures and is sensitive to their lengths, permeabilities, and intersection angles. Correspondingly, it contains key information on the governing hydraulic properties of fractured rock masses and hence should be accounted for whenever realistic seismic models of such media are needed.Facultad de Ciencias Astronómicas y Geofísica

Multimodal assessment shows a mostly preserved cognitive status in incidentally discovered low grade gliomas: A single institution study

Incidentally discovered low-grade gliomas (iLGGs) are poorly reported in the literature. Still less is known about iLGG patients\u2019 neuropsychological profile: It is unclear whether iLGG patients are cognitively proficient, thus further confirming the concept of asymptomatic. From our monoinstitutional cohort of 332 patients operated for LGG from 2000 to 2017 we selected those who underwent a neuropsychological testing (n = 217, from 2008 to 2017), and identified 24 young (mean age 38.5 \ub1 1.06) patients with iLGGs (16 of 24, left hemisphere iLGGs, 8 of 24 right hemisphere iLGGs). The maximum lesions overlap occurred in the left inferior frontal gyrus and in the right anterior cingulate/superior medial frontal gyrus. Patients were cognitively preserved except mild to borderline difficulties in a few of them. The analysis of the equivalent scores (a score laying below or equal to the external nonparametric tolerance limit of adjusted scores corresponding to 0, 1, 2 and 3 are intermediate) highlighted the presence of additional borderline performances. Molecular class correlated with a normal function at visual\u2013spatial intelligence (p = 0.05) and at spatial short-term memory (p = 0.029). Results indicate that at this time of tumor growth, patients\u2019 cognitive abilities are still functional, but are slowly approaching the borderline level

Seismoacoustic signatures of fracture connectivity

Wave-induced fluid flow (WIFF) between fractures and the embedding matrix as well as within connected fractures tends to produce significant seismic attenuation and velocity dispersion. While WIFF between fractures and matrix is well understood, the corresponding effects related to fracture connectivity and the characteristics of the energy dissipation due to flow within fractures are largely unexplored. In this work, we use oscillatory relaxation simulations based on the quasi-static poroelastic equations to study these phenomena. We first consider synthetic rock samples containing connected and unconnected fractures and compute the corresponding attenuation and phase velocity. We also determine the relative fluid displacement and pressure fields in order to gain insight into the physical processes involved in the two manifestations of WIFF in fractured media. To quantify the contributions of the two WIFF mechanisms to the total seismic attenuation, we compute the spatial distribution of the local energy dissipation. Finally, we perform an exhaustive sensitivity analysis to study the role played by different characteristics of fracture networks on the seismic signatures. We show that in the presence of connected fractures both P wave attenuation and phase velocity are sensitive to some key characteristics of the probed medium, notably to the lengths, permeabilities, and intersection angles of the fractures as well as to the overall degree of connectivity of the fracture network. This, in turn, indicates that a deeper understanding of these two manifestations of WIFF in fractured media may eventually allow for the extraction of some of these properties from seismic data.Facultad de Ciencias Astronómicas y Geofísica

Seismoacoustic signatures of fracture connectivity

Wave-induced fluid flow (WIFF) between fractures and the embedding matrix as well as within connected fractures tends to produce significant seismic attenuation and velocity dispersion. While WIFF between fractures and matrix is well understood, the corresponding effects related to fracture connectivity and the characteristics of the energy dissipation due to flow within fractures are largely unexplored. In this work, we use oscillatory relaxation simulations based on the quasi-static poroelastic equations to study these phenomena. We first consider synthetic rock samples containing connected and unconnected fractures and compute the corresponding attenuation and phase velocity. We also determine the relative fluid displacement and pressure fields in order to gain insight into the physical processes involved in the two manifestations of WIFF in fractured media. To quantify the contributions of the two WIFF mechanisms to the total seismic attenuation, we compute the spatial distribution of the local energy dissipation. Finally, we perform an exhaustive sensitivity analysis to study the role played by different characteristics of fracture networks on the seismic signatures. We show that in the presence of connected fractures both P wave attenuation and phase velocity are sensitive to some key characteristics of the probed medium, notably to the lengths, permeabilities, and intersection angles of the fractures as well as to the overall degree of connectivity of the fracture network. This, in turn, indicates that a deeper understanding of these two manifestations of WIFF in fractured media may eventually allow for the extraction of some of these properties from seismic data.Facultad de Ciencias Astronómicas y Geofísica

Evaluation of potential miRNA sponge effects of SARS genomes in human

: To date the coronavirus family is composed of seven different viruses which were commonly known as cold viruses until the appearance of the severe acute respiratory coronavirus (SARS-CoV) in 2002, the middle east respiratory syndrome coronavirus (MERS) in 2012 and the severe acute respiratory coronavirus 2 (SARS-CoV-2) which caused the COVID-19 global pandemic in 2019. Using bioinformatic approaches we tested the potential interactions of human miRNAs, expressed in pulmonary epithelial cells, with the available coronavirus genomes. Putative miRNA binding sites were then compared between pathogenic and non pathogenic virus groups. The pathogenic group shares 6 miRNA binding sites that can be potentially involved in the sequestration of miRNAs already known to be associated with deep vein thrombosis. We then analysed ∼100k SARS-CoV-2 variant genomes for their potential interaction with human miRNAs and this study highlighted a group of 97 miRNA binding sites which is present in all the analysed genomes. Among these, we identified 6 miRNA binding sites specific for SARS-CoV-2 and the other two pathogenic viruses whose down-regulation has been seen associated with deep vein thrombosis and cardiovascular diseases. Interestingly, one of these miRNAs, namely miR-20a-5p, whose expression decreases with advancing age, is involved in cytokine signaling, cell differentiation and/or proliferation. We hypothesize that depletion of poorly expressed miRNA could be related with disease severity

Autologous bone marrow mononuclear cells (Bmmcs) for the treatment of uncomplicated grade 2 ununited anconeal process (uap) in six dogs: Preliminary results

The aim of this study was to report the results of autologous bone marrow mononuclear cell (BMMC) transplantation as a minimally invasive treatment for grade 2 UAP in dogs. This was an observational case series on six German shepherd dogs affected by grade 2 UAP as defined according to their clinical condition as well as radiographic and CT findings. Bone marrow was collected from the iliac crest and the mononuclear fraction was separated with density gradient centrifugation. Cells were suspended in fibrin glue before BMMC administration and implanted via transcutaneous injection under IB or CT guidance, using a spinal needle directly inserted into the ossification centre between the anconeal process and the olecranon. Clinical and radiographic follow-up was performed for up to 6 months. Microradiographic assessment was performed on one dog that died of other causes. A progressive reduction of pain within 3 weeks after BMMC administration was observed in all dogs, with gradually increased weight bearing on the affected limb. Radiographic and CT follow-up revealed the progressive fusion of the ossification centre at 90 days without any signs of secondary OA. The examination of microradiographs showed newly formed bone tissue in which a residue of calcified cartilage was present at the site of BMMC implantation. On the basis of these results, BMMC therapy for grade 2 UAP may be considered to be an effective and minimally invasive treatment option for dogs