289 research outputs found
Reproducibility and Discriminability of Brain Patterns of Semantic Categories Enhanced by Congruent Audiovisual Stimuli
One of the central questions in cognitive neuroscience is the precise neural representation, or brain pattern, associated with a semantic category. In this study, we explored the influence of audiovisual stimuli on the brain patterns of concepts or semantic categories through a functional magnetic resonance imaging (fMRI) experiment. We used a pattern search method to extract brain patterns corresponding to two semantic categories: âold peopleâ and âyoung people.â These brain patterns were elicited by semantically congruent audiovisual, semantically incongruent audiovisual, unimodal visual, and unimodal auditory stimuli belonging to the two semantic categories. We calculated the reproducibility index, which measures the similarity of the patterns within the same category. We also decoded the semantic categories from these brain patterns. The decoding accuracy reflects the discriminability of the brain patterns between two categories. The results showed that both the reproducibility index of brain patterns and the decoding accuracy were significantly higher for semantically congruent audiovisual stimuli than for unimodal visual and unimodal auditory stimuli, while the semantically incongruent stimuli did not elicit brain patterns with significantly higher reproducibility index or decoding accuracy. Thus, the semantically congruent audiovisual stimuli enhanced the within-class reproducibility of brain patterns and the between-class discriminability of brain patterns, and facilitate neural representations of semantic categories or concepts. Furthermore, we analyzed the brain activity in superior temporal sulcus and middle temporal gyrus (STS/MTG). The strength of the fMRI signal and the reproducibility index were enhanced by the semantically congruent audiovisual stimuli. Our results support the use of the reproducibility index as a potential tool to supplement the fMRI signal amplitude for evaluating multimodal integration
Cellular network based multistatic integrated sensing and communication systems
A novel multistatic integrated sensing and communication (ISAC) system based on cellular network is proposed. It can make use of widespread base stations (BSs) to perform cooperative sensing in wide area. This system is important since the deployment of sensing function can be achieved upon the mobile communication network at low complexity and cost without modifying the architecture of BSs for full duplexing. In this work, the topology of sensing cell is first provided, which can be duplicated to seamlessly cover the cellular network. Each sensing cell consists of a single central BS transmitting signals and multiple neighboring BSs receiving reflected signals from sensing objects. Then an estimating approach is described for obtaining position and velocity of sensing objects that locate in the sensing cell. Joint data processing with an efficient optimization method is also provided. In addition, key issues in the cellular network based multistatic ISAC system are analyzed. Simulation results show that the multistatic ISAC system can reduce interference power by over 10 dBm and significantly improve position and velocity estimation accuracy of objects when compared with the monostatic ISAC system, demonstrating the effectiveness and promise of implementing the proposed system in the mobile network
Genome sequence of the cultivated cotton <i>Gossypium arboreum</i>
The complex allotetraploid nature of the cotton genome (AADD; 2n = 52) makes genetic, genomic and functional analyses extremely challenging. Here we sequenced and assembled the Gossypium arboreum (AA; 2n = 26) genome, a putative contributor of the A subgenome. A total of 193.6 Gb of clean sequence covering the genome by 112.6-fold was obtained by paired-end sequencing. We further anchored and oriented 90.4% of the assembly on 13 pseudochromosomes and found that 68.5% of the genome is occupied by repetitive DNA sequences. We predicted 41,330 protein-coding genes in G. arboreum. Two whole-genome duplications were shared by G. arboreum and Gossypium raimondii before speciation. Insertions of long terminal repeats in the past 5 million years are responsible for the twofold difference in the sizes of these genomes. Comparative transcriptome studies showed the key role of the nucleotide binding site (NBS)-encoding gene family in resistance to Verticillium dahliae and the involvement of ethylene in the development of cotton fiber cells.Genetics & HereditySCI(E)[email protected]; [email protected]; [email protected]
Baiji genomes reveal low genetic variability and new insights into secondary aquatic adaptations
The baiji, or Yangtze River dolphin (Lipotes vexillifer), is a flagship species for the conservation of aquatic animals and ecosystems in the Yangtze River of China; however, this species has now been recognized as functionally extinct. Here we report a high-quality draft genome and three re-sequenced genomes of L. vexillifer using Illumina short-read sequencing technology. Comparative genomic analyses reveal that cetaceans have a slow molecular clock and molecular adaptations to their aquatic lifestyle. We also find a significantly lower number of heterozygous single nucleotide polymorphisms in the baiji compared to all other mammalian genomes reported thus far. A reconstruction of the demographic history of the baiji indicates that a bottleneck occurred near the end of the last deglaciation, a time coinciding with a rapid decrease in temperature and the rise of eustatic sea level
Search for the decay
We search for radiative decays into a weakly interacting neutral
particle, namely an invisible particle, using the produced through the
process in a data sample of
decays collected by the BESIII detector
at BEPCII. No significant signal is observed. Using a modified frequentist
method, upper limits on the branching fractions are set under different
assumptions of invisible particle masses up to 1.2 . The upper limit corresponding to an invisible particle with zero mass
is 7.0 at the 90\% confidence level
Mudskipper genomes provide insights into the terrestrial adaptation of amphibious fishes
Mudskippers are amphibious fishes that have developed morphological and physiological adaptations to match their unique lifestyles. Here we perform whole-genome sequencing of four representative mudskippers to elucidate the molecular mechanisms underlying these adaptations. We discover an expansion of innate immune system genes in the mudskippers that may provide defence against terrestrial pathogens. Several genes of the ammonia excretion pathway in the gills have experienced positive selection, suggesting their important roles in mudskippersâ tolerance to environmental ammonia. Some vision-related genes are differentially lost or mutated, illustrating genomic changes associated with aerial vision. Transcriptomic analyses of mudskippers exposed to air highlight regulatory pathways that are up- or down-regulated in response to hypoxia. The present study provides a valuable resource for understanding the molecular mechanisms underlying water-to-land transition of vertebrates
Single-cell-resolution transcriptome map revealed novel genes involved in testicular germ cell progression and somatic cells specification in Chinese tongue sole with sex reversal
19 pages, 7 figures, supporting information https://doi.org/10.1007/s11427-021-2236-4.-- Data availability: The data reported in this study are available in the CNGB Nucleotide Sequence Archive (CNSA: https://db.cngb.org/cnsa; accession number CNP0002135).Female-to-male sex reversals (pseudomales) are common in lower vertebrates and have been found in natural populations, which is a concern under rapid changes in environmental conditions. Pseudomales can exhibit altered spermatogenesis. However, the regulatory mechanisms underlying pseudomale spermatogenesis remain unclear. Here, we characterized spermatogenesis in Chinese tongue sole (Cynoglossus semilaevis), a species with genetic and environmental sex determination, based on a high-resolution single-cell RNA-seq atlas of cells derived from the testes of genotypic males and pseudomales. We identified five germ cell types and six somatic cell types and obtained a single-cell atlas of dynamic changes in gene expression during spermatogenesis in Chinese tongue sole, including alterations in pseudomales. We detected decreased levels of Ca2+ signaling pathway-related genes in spermatogonia, insufficient meiotic initiation in spermatocytes, and a malfunction of somatic niche cells in pseudomales. However, a cluster of CaSR genes and MAPK signaling factors were upregulated in undifferentiated spermatogonia of pseudomales. Additionally, we revealed that Z chromosome-specific genes, such as piwil2, dhx37, and ehmt1, were important for spermatogenesis. These results improve our understanding of reproduction after female-to-male sex-reversal and provide new insights into the adaptability of reproductive strategies in lower vertebratesThis work was supported by the National Key R&D Program of China (2018YFD0900301), the National Nature Science Foundation of China (31722058, 31802275, 31472269), the AoShan Talents Cultivation Program Supported by Qingdao National Laboratory for Marine Science and Technology (2017ASTCP-ES06), the Taishan Scholar Project Fund of Shandong of China to C.S., the National Ten-Thousands Talents Special Support Program to C.S., the Central Public-interest Scientific Institution Basal Research Fund, CAFS (2020TD19) and the China Agriculture Research System (CARS-47-G03)With the institutional support of the âSevero Ochoa Centre of Excellenceâ accreditation (CEX2019-000928-S)Peer reviewe
Eighteen-year follow-up report of the surveillance and prevention of an HIV/AIDS outbreak amongst plasma donors in Hebei Province, China
6G Network AI Architecture for Everyone-Centric Customized Services
Mobile communication standards were developed for enhancing transmission and
network performance by using more radio resources and improving spectrum and
energy efficiency. How to effectively address diverse user requirements and
guarantee everyone's Quality of Experience (QoE) remains an open problem. The
Sixth Generation (6G) mobile systems will solve this problem by utilizing
heterogenous network resources and pervasive intelligence to support
everyone-centric customized services anywhere and anytime. In this article, we
first coin the concept of Service Requirement Zone (SRZ) on the user side to
characterize and visualize the integrated service requirements and preferences
of specific tasks of individual users. On the system side, we further introduce
the concept of User Satisfaction Ratio (USR) to evaluate the system's overall
service ability of satisfying a variety of tasks with different SRZs. Then, we
propose a network Artificial Intelligence (AI) architecture with integrated
network resources and pervasive AI capabilities for supporting customized
services with guaranteed QoEs. Finally, extensive simulations show that the
proposed network AI architecture can consistently offer a higher USR
performance than the cloud AI and edge AI architectures with respect to
different task scheduling algorithms, random service requirements, and dynamic
network conditions
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