A Three-Pole Substrate Integrated Waveguide Bandpass Filter Using New Coupling Scheme

A novel three-pole substrate integrated waveguide (SIW) bandpass filter (BPF) using new coupling scheme is proposed in this paper. Two high order degenerate modes (TE102 and TE201) of a square SIW cavity and a dominant mode (TE101) of a rectangular SIW cavity are coupled to form a three-pole SIW BPF. The coupling scheme of the structure is given and analyzed. Due to the coupling between two cavities, as well as the coupling between source and load, three transmission zeros are created in the stopband of the filter. The proposed three-pole SIW BPF is designed and fabricated. Good agreement between simulated and measured results verifies the validity of the design methodology well

H5N1 virus resistant to antiviral drug

1. This study investigated the geographical distribution and growth properties of avian influenza A (H5N1) isolates with mutations that confer resistance to amantadine and rimantadine. It also explored whether naturally occurring mutations associated with resistance to oseltamivir are present at a low frequency in H5N1 isolates and if so, whether these quasi-species may be the source of the emergence of oseltamivir-resistant strains following exposure to this drug. 2. Naturally occurring avian H5N1 virus mutants resistant to the main types of antiviral drugs were noted. 3. The fitness of these mutants in avian and mammalian hosts needs further investigation.published_or_final_versio

Specific heat and thermal conductivity of ferromagnetic magnons in Yttrium Iron Garnet

The specific heat and thermal conductivity of the insulating ferrimagnet Y$_3$Fe$_5$O$_{12}$ (Yttrium Iron Garnet, YIG) single crystal were measured down to 50 mK. The ferromagnetic magnon specific heat $C$$_m$ shows a characteristic $T^{1.5}$ dependence down to 0.77 K. Below 0.77 K, a downward deviation is observed, which is attributed to the magnetic dipole-dipole interaction with typical magnitude of 10$^{-4}$ eV. The ferromagnetic magnon thermal conductivity $\kappa_m$ does not show the characteristic $T^2$ dependence below 0.8 K. To fit the $\kappa_m$ data, both magnetic defect scattering effect and dipole-dipole interaction are taken into account. These results complete our understanding of the thermodynamic and thermal transport properties of the low-lying ferromagnetic magnons.Comment: 5 pages, 5 figure

Bayesian optimization for the inverse scattering problem in quantum reaction dynamics

We propose a machine-learning approach based on Bayesian optimization to build global potential energy surfaces (PES) for reactive molecular systems using feedback from quantum scattering calculations. The method is designed to correct for the uncertainties of quantum chemistry calculations and yield potentials that reproduce accurately the reaction probabilities in a wide range of energies. These surfaces are obtained automatically and do not require manual fitting of the {\it ab initio} energies with analytical functions. The PES are built from a small number of {\it ab initio} points by an iterative process that incrementally samples the most relevant parts of the configuration space. Using the dynamical results of previous authors as targets, we show that such feedback loops produce accurate global PES with 30 {\it ab initio} energies for the three-dimensional H + H$_2$ $\rightarrow$ H$_2$ + H reaction and 290 {\it ab initio} energies for the six-dimensional OH + H$_2$ $\rightarrow$ H$_2$O + H reaction. These surfaces are obtained from 360 scattering calculations for H$_3$ and 600 scattering calculations for OH$_3$. We also introduce a method that quickly converges to an accurate PES without the {\it a priori} knowledge of the dynamical results. By construction, our method illustrates the lowest number of potential energy points (i.e. the minimum information) required for the non-parametric construction of global PES for quantum reactive scattering calculations.Comment: 9 pages, 8 figure

Quantum criticality and nodal superconductivity in the FeAs-based superconductor KFe2As2

The in-plane resistivity $\rho$ and thermal conductivity $\kappa$ of FeAs-based superconductor KFe$_2$As$_2$ single crystal were measured down to 50 mK. We observe non-Fermi-liquid behavior $\rho(T) \sim T^{1.5}$ at $H_{c_2}$ = 5 T, and the development of a Fermi liquid state with $\rho(T) \sim T^2$ when further increasing field. This suggests a field-induced quantum critical point, occurring at the superconducting upper critical field $H_{c_2}$. In zero field there is a large residual linear term $\kappa_0/T$, and the field dependence of $\kappa_0/T$ mimics that in d-wave cuprate superconductors. This indicates that the superconducting gaps in KFe$_2$As$_2$ have nodes, likely d-wave symmetry. Such a nodal superconductivity is attributed to the antiferromagnetic spin fluctuations near the quantum critical point.Comment: 4 pages, 4 figures - replaces arXiv:0909.485

KDM2B/FBXL10 targets c-Fos for ubiquitylation and degradation in response to mitogenic stimulation.

KDM2B (also known as FBXL10) controls stem cell self-renewal, somatic cell reprogramming and senescence, and tumorigenesis. KDM2B contains multiple functional domains, including a JmjC domain that catalyzes H3K36 demethylation and a CxxC zinc-finger that recognizes CpG islands and recruits the polycomb repressive complex 1. Here, we report that KDM2B, via its F-box domain, functions as a subunit of the CUL1-RING ubiquitin ligase (CRL1/SCF(KDM2B)) complex. KDM2B targets c-Fos for polyubiquitylation and regulates c-Fos protein levels. Unlike the phosphorylation of other SCF (SKP1-CUL1-F-box)/CRL1 substrates that promotes substrates binding to F-box, epidermal growth factor (EGF)-induced c-Fos S374 phosphorylation dissociates c-Fos from KDM2B and stabilizes c-Fos protein. Non-phosphorylatable and phosphomimetic mutations at S374 result in c-Fos protein which cannot be induced by EGF or accumulates constitutively and lead to decreased or increased cell proliferation, respectively. Multiple tumor-derived KDM2B mutations impaired the function of KDM2B to target c-Fos degradation and to suppress cell proliferation. These results reveal a novel function of KDM2B in the negative regulation of cell proliferation by assembling an E3 ligase to targeting c-Fos protein degradation that is antagonized by mitogenic stimulations