16,912 research outputs found
A Three-Pole Substrate Integrated Waveguide Bandpass Filter Using New Coupling Scheme
A novel three-pole substrate integrated waveguide (SIW) bandpass filter (BPF) using new coupling scheme is proposed in this paper. Two high order degenerate modes (TE102 and TE201) of a square SIW cavity and a dominant mode (TE101) of a rectangular SIW cavity are coupled to form a three-pole SIW BPF. The coupling scheme of the structure is given and analyzed. Due to the coupling between two cavities, as well as the coupling between source and load, three transmission zeros are created in the stopband of the filter. The proposed three-pole SIW BPF is designed and fabricated. Good agreement between simulated and measured results verifies the validity of the design methodology well
H5N1 virus resistant to antiviral drug
1. This study investigated the geographical distribution and growth properties of avian influenza A (H5N1) isolates with mutations that confer resistance to amantadine and rimantadine. It also explored whether naturally occurring mutations associated with resistance to oseltamivir are present at a low frequency in H5N1 isolates and if so, whether these quasi-species may be the source of the emergence of oseltamivir-resistant strains following exposure to this drug. 2. Naturally occurring avian H5N1 virus mutants resistant to the main types of antiviral drugs were noted. 3. The fitness of these mutants in avian and mammalian hosts needs further investigation.published_or_final_versio
Specific heat and thermal conductivity of ferromagnetic magnons in Yttrium Iron Garnet
The specific heat and thermal conductivity of the insulating ferrimagnet
YFeO (Yttrium Iron Garnet, YIG) single crystal were measured
down to 50 mK. The ferromagnetic magnon specific heat shows a
characteristic dependence down to 0.77 K. Below 0.77 K, a downward
deviation is observed, which is attributed to the magnetic dipole-dipole
interaction with typical magnitude of 10 eV. The ferromagnetic magnon
thermal conductivity does not show the characteristic
dependence below 0.8 K. To fit the data, both magnetic defect
scattering effect and dipole-dipole interaction are taken into account. These
results complete our understanding of the thermodynamic and thermal transport
properties of the low-lying ferromagnetic magnons.Comment: 5 pages, 5 figure
Bayesian optimization for the inverse scattering problem in quantum reaction dynamics
We propose a machine-learning approach based on Bayesian optimization to
build global potential energy surfaces (PES) for reactive molecular systems
using feedback from quantum scattering calculations. The method is designed to
correct for the uncertainties of quantum chemistry calculations and yield
potentials that reproduce accurately the reaction probabilities in a wide range
of energies. These surfaces are obtained automatically and do not require
manual fitting of the {\it ab initio} energies with analytical functions. The
PES are built from a small number of {\it ab initio} points by an iterative
process that incrementally samples the most relevant parts of the configuration
space. Using the dynamical results of previous authors as targets, we show that
such feedback loops produce accurate global PES with 30 {\it ab initio}
energies for the three-dimensional H + H H + H reaction
and 290 {\it ab initio} energies for the six-dimensional OH + H
HO + H reaction. These surfaces are obtained from 360
scattering calculations for H and 600 scattering calculations for OH.
We also introduce a method that quickly converges to an accurate PES without
the {\it a priori} knowledge of the dynamical results. By construction, our
method illustrates the lowest number of potential energy points (i.e. the
minimum information) required for the non-parametric construction of global PES
for quantum reactive scattering calculations.Comment: 9 pages, 8 figure
Quantum criticality and nodal superconductivity in the FeAs-based superconductor KFe2As2
The in-plane resistivity and thermal conductivity of
FeAs-based superconductor KFeAs single crystal were measured down to 50
mK. We observe non-Fermi-liquid behavior at =
5 T, and the development of a Fermi liquid state with when
further increasing field. This suggests a field-induced quantum critical point,
occurring at the superconducting upper critical field . In zero field
there is a large residual linear term , and the field dependence of
mimics that in d-wave cuprate superconductors. This indicates that
the superconducting gaps in KFeAs have nodes, likely d-wave symmetry.
Such a nodal superconductivity is attributed to the antiferromagnetic spin
fluctuations near the quantum critical point.Comment: 4 pages, 4 figures - replaces arXiv:0909.485
KDM2B/FBXL10 targets c-Fos for ubiquitylation and degradation in response to mitogenic stimulation.
KDM2B (also known as FBXL10) controls stem cell self-renewal, somatic cell reprogramming and senescence, and tumorigenesis. KDM2B contains multiple functional domains, including a JmjC domain that catalyzes H3K36 demethylation and a CxxC zinc-finger that recognizes CpG islands and recruits the polycomb repressive complex 1. Here, we report that KDM2B, via its F-box domain, functions as a subunit of the CUL1-RING ubiquitin ligase (CRL1/SCF(KDM2B)) complex. KDM2B targets c-Fos for polyubiquitylation and regulates c-Fos protein levels. Unlike the phosphorylation of other SCF (SKP1-CUL1-F-box)/CRL1 substrates that promotes substrates binding to F-box, epidermal growth factor (EGF)-induced c-Fos S374 phosphorylation dissociates c-Fos from KDM2B and stabilizes c-Fos protein. Non-phosphorylatable and phosphomimetic mutations at S374 result in c-Fos protein which cannot be induced by EGF or accumulates constitutively and lead to decreased or increased cell proliferation, respectively. Multiple tumor-derived KDM2B mutations impaired the function of KDM2B to target c-Fos degradation and to suppress cell proliferation. These results reveal a novel function of KDM2B in the negative regulation of cell proliferation by assembling an E3 ligase to targeting c-Fos protein degradation that is antagonized by mitogenic stimulations
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