15 research outputs found
Hydrogenated Amorphous Silicon Thin-Film Disk Resonators
AbstractMicroelectromechanical (MEMS) structures consisting of surface micromachined disk resonators of phosphorous- doped hydrogenated amorphous silicon (n-a-Si:H) deposited by radiofrequency plasma enhanced chemical vapour deposition (RF-PECVD) were fabricated and characterized. Quality factors up to 104 in vacuum were measured for disk resonators operating at frequencies between 0.1 and 10MHz. The metallized structures were actuated with electrostatic force by radially placed electrodes. Finite element simulations were used to identify the type of vibrational modes present and show good agreement with measured values. Resonator geometry and ambient pressure were varied to attain a generalized understanding of the RF performance. Higher harmonic modes show increasing quality factors which bears great potential when designing sensors for operation in dissipative media
Ki-67 Proliferation Index in Gastric Cancer - Biologic Significance
Objectives/Introdution:
Ki-67 protein has been used as an indicator of proliferation activity in tumor cells. In gastric cancer the prognostic value has not been fully understood. This study was designed to assess the biologic significance of Ki-67 proliferation index (PI) in gastric cancer.
Material/Methods:
Seventy-two patients with gastric cancer were evaluated. These patients underwent gastric resection, and the tumor tissue was stained immunohistochemically. Ki-67 PI
was defined as the percentage of tumor cells positive for Ki-67. Ki-67 PI was correlated with clinicopathological characteristics and patient survival.
Results:
A low Ki-67 PI (less than or equal to 50%) was associated with poorly differentiated histology - diffuse type (p=0.009) and signet ring cells (p=0.004) - and younger age
(p=0.022). A worse prognosis in patients with low Ki-67 PI was also found (a mean survival of 41.8 vs 63 months for high Ki-67 PI group), but not statistically significant (p=0.623, log rank test).
Discussion/Conclusion:
We found an inversely correlation between Ki-67 PI and histological differentiation grade. Patients in group with low Ki-67 PI are younger, with poorly differentiated histology and have a lower mean survival. Like other studies already suggested, we may have two different tumors phenotypes - highly invasive with low proliferative capability, and less invasive potential with higher proliferative ability. However, in this sample, no significant prognostic value was achieved between both