Association of lung function decline with the heme oxygenase‐1 gene promoter microsatellite polymorphism in a general population sample. Results from the European Community Respiratory Health Survey (ECRHS), France

Inducible heme oxygenase (HO‐1) acts against oxidants that are thought to play a major role in the pathogenesis of chronic obstructive pulmonary disease (COPD), characterised by impaired lung function. A (GT)n repeat polymorphism in the HO‐1 gene promoter can modulate the gene transcription in response to oxidative stress. We hypothesised that this polymorphism could be associated with the level of lung function and decline in subjects exposed to oxidative agression (smokers). We genotyped 749 French subjects (20–44 years, 50% men, 40% never smokers) examined in both 1992 and 2000 as part of the ECRHS. Lung function was assessed by forced expiratory volume in 1 second (FEV1) and FEV1/forced ventilatory capacity (FVC) ratio. We compared long (L) allele carriers ((GT)n ⩾33 repeats for one or two alleles) to non‐carriers. Cross sectionally, in 2000, L allele carriers showed lower FEV1/FVC than non‐carriers. During the 8 year period, the mean annual FEV1 and FEV1/FVC declines were −30.9 (31.1) ml/year and −1.8 (6.1) U/year, respectively. FEV1/FVC decline was steeper in L allele carriers than in non‐carriers (−2.6 (5.5) v −1.5 (6.4), p = 0.07). There was a strong interaction between the L allele and smoking. In 2000, the L allele was associated with lower FEV1 and FEV1/FVC in heavy smokers (⩾20 cigarettes/day) only (p for interaction = 0.07 and 0.002 respectively). Baseline heavy smokers carrying the L allele showed the steepest FEV1 decline (−62.0 (29.5 ml/year) and the steepest FEV1/FVC decline (−8.8 (5.4 U/year) (p for interaction = 0.009 and 0.0006).These results suggest that a long (L) HO‐1 gene promoter in heavy smokers is associated with susceptibility to develop airway obstruction

Left ventriculo-arterial uncoupling after recovery from myocardial infarction in dogs.

info:eu-repo/semantics/publishe

Left ventriculo-arterial uncoupling after recovery from myocardial infarction in dogs

info:eu-repo/semantics/publishe

Left ventriculo-arterial uncoupling after recovery from myocardial infarction in dogs.

info:eu-repo/semantics/nonPublishe

Dietary anthocyanin intake and age-related decline in lung function: longitudinal findings from the VA Normative Aging Study

Background: It is unknown if habitual intake of dietary flavonoids, known for their antioxidative and anti-inflammatory properties, affects longitudinal change in lung function. Objective: We investigated if different flavonoid subclasses present in the habitual diet were associated with beneficial changes in lung function over time in the elderly. Design: This longitudinal analysis included 839 participants from the VA Normative Aging Study whose lung function (FEV1 and FVC) was measured at two and up to five visits between 1992 and 2008 (n = 2,623 measurements). Yearly average intake of major flavonoid subclasses (anthocyanins, flavanones, flavan-3-ols, flavonols, flavones, and polymers) was calculated from food-frequency questionnaires at each visit. We estimated adjusted differences in annual change in lung function associated with each flavonoid subclass, categorized into quartiles, in linear mixed-effect regression models after adjustment for lifestyle and dietary confounders. Results: Strong inverse associations were found between anthocyanin intake and age related decline in lung function. Independent of dietary and non-dietary risk factors, slower rates of FEV1 and FVC decline by 23.6 mL/y (95% confidence interval [CI]: 16.6,30.7) and 37.3 mL/y (95%CI: 27.8, 46.8), respectively, were observed in participants in the fourth quartile of intake compared with participants in the first quartile (Ptrend <0.0001). The protective associations observed for anthocyanin intake were present in both current/former and never smokers. Compared with no or very low intake, intake of ≥ 2servings/week of anthocyanin-rich blueberries was associated with slower decline in FEV1 and FVC by 22.5 mL/y (95%CI: 10.8, 34.2) and 37.9 mL/y (95%CI: 22.1, 53.7),respectively. To a lesser extent, higher flavan-3-ol intake 92 was also associated with slowerlung function decline. Conclusion: Attenuation of age-related lung function decline was associated with higher dietary anthocyanin intake in this longitudinal sample of predominantly elderly men.Further prospective studies are needed to confirm these novel associations.