Encerramento dos diastemas interincisivos em jovens: abordagem multidisciplinar

Diastema interincisivo maxilar é caracterizado por um espaçamento aumentado entre os incisivos superiores e comum durante as fases de dentição mista e dentição permanente precoce. Na realidade, o aparecimento desse espaçamento constitui um aspeto de normalidade na fase de dentição mista e geralmente não requer qualquer tratamento ativo. A sua persistência depende da etiologia frequentemente multicausal. O diagnóstico diferencial dessa anomalia deve ser realizado o mais cedo possível para estabelecer um plano de tratamento individualizado específico e identificar o momento apropriado para intervir se necessário, de modo a permitir o sucesso no fecho deste espaçamento. De modo a alcançar um resultado positivo e a satisfação do paciente, uma abordagem de tratamento multidisciplinar é quase sempre uma opção mais segura e eficaz para o tratamento destes jovens pacientes. Atualmente, existem várias alternativas de tratamento eficazes, desde a ortodontia, cirurgia, medicina dentária restauradora e várias combinações destas. Devido à forte tendência para a recidiva do diastema após o encerramento do espaço, a contenção deve ser sempre considerada no tratamento. O objetivo desta revisão sistemática integrativa, foi analisar os fatores etiológicos no aparecimento de diastema interincisivo maxilar e comparar as opções de tratamento encontrados nas dentições mista e nos jovens adultos. De 2010 à atualidade, foi realizada uma pesquisa bibliográfica na base de dados PubMed, GoogleScholar e motor de busca ScienceDirect e com restrição de resumos relevantes para a presente dissertação. Foram selecionados diferentes tipos de artigos bem como capítulos de livros e dissertações

Nautilia abyssi sp. nov., a thermophilic, chemolithoautotrophic, sulfur-reducing bacterium isolated from an East Pacific Rise hydrothermal vent

This is an author manuscript that has been accepted for publication in International Journal of Systematic and Evolutionary Microbiology, copyright Society for General Microbiology, but has not been copy-edited, formatted or proofed. Cite this article as appearing in International Journal of Systematic and Evolutionary Microbiology. This version of the manuscript may not be duplicated or reproduced, other than for personal use or within the rule of 'Fair Use of Copyrighted Materials' (section 17, Title 17, US Code), without permission from the copyright owner, Society for General Microbiology. The Society for General Microbiology disclaims any responsibility or liability for errors or omissions in this version of the manuscript or in any version derived from it by any other parties. The final copy-edited, published article, which is the version of record, can be found at http://mic.sgmjournals.org, and is freely available without a subscription.International audienceA novel strictly anaerobic, thermophilic, sulfur-reducing bacterium, designated PH1209(T), was isolated from an East Pacific Rise hydrothermal vent (1 degrees N) sample and studied using a polyphasic taxonomic approach. Cells were Gram-negative, motile rods (approx. 1.60 x 0.40 microm) with a single polar flagellum. Strain PH1209(T) grew at temperatures between 33 and 65 degrees C (optimum 60 degrees C), from pH 5.0 to 8.0 (optimum 6.0-6.5), and between 2 and 4 % (w/v) NaCl (optimum 3 %). Cells grew chemolithoautotrophically with H(2) as an energy source, S(0) as an electron acceptor and CO(2) as a carbon source. Strain PH1209(T) was also able to use peptone and yeast extract as carbon sources. The G+C content of the genomic DNA was 35 mol%. Phylogenetic analyses based on 16S rRNA gene sequencing showed that strain PH1209(T) fell within the order Nautiliales, in the class Epsilonproteobacteria. Comparative 16S rRNA gene sequence analysis indicated that strain PH1209(T) belonged to the genus Nautilia and shared 97.2 and 98.7 % 16S rRNA gene sequence identity, respectively, with the type strains of Nautilia lithotrophica and Nautilia profundicola. It is proposed, from the polyphasic evidence, that the strain represents a novel species, Nautilia abyssi sp. nov.; the type strain is PH1209(T) (=DSM 21157(T)=JCM 15390(T))

Comparative Analysis of Urso- and Tauroursodeoxycholic Acid Neuroprotective Effects on Retinal Degeneration Models

Ursodeoxycholic (UDCA) and tauroursodeoxycholic (TUDCA) acids have shown neuroprotective properties in neurodegenerative diseases, but differential effects of the two bile acids have been poorly explored. The aim of this study was to evaluate the neuroprotective effects of UDCA versus TUDCA in a neuroretinal degeneration model and to compare transcriptionally regulated pathways. The WERI-Rb-1 human cone-like cell line and retinal explants were exposed to albumin and TUDCA or UDCA. Viability, cell death, and microglial activation were quantified. Transcriptionally regulated pathways were analyzed after RNA sequencing using the edgeR bioconductor package. Pre-treatment of cone-like cells with UDCA or TUDCA significantly protected cells from albumin toxicity. On retinal explants, either bile acid reduced apoptosis, necroptosis, and microglia activation at 6 h. TUDCA induced the regulation of 463 genes, whilst 31 genes were regulated by UDCA. Only nineteen common genes were regulated by both bile acids, mainly involved in iron control, cell death, oxidative stress, and cell metabolism. As compared to UDCA, TUDCA up-regulated genes involved in endoplasmic reticulum stress pathways and down-regulated genes involved in axonal and neuronal development. Either bile acid protected against albumin-induced cell loss. However, TUDCA regulated substantially more neuroprotective genes than UDCA

La monographie d’artiste

Comment la monographie d’artiste, genre fondateur de l’histoire de l’art, a-t-elle su s’adapter à l’éclatement du concept d’œuvre et à la crise de la notion d’auteur ? Des débats sur l’actualité et l’adaptation du genre, des livres de poche aux grandes expositions ; des synthèses sur l’écriture monographique, de l’art grec à l’architecture du xxe siècle ; des points de vue comparatistes sur des monographies de peintres, de compositeurs, de cinéastes… Tabula Gratulatori Alain Aubry (Club français du livre), Marc Blondeau et Étienne Bréton (Blondeau et associés), Maurizio Canesso (Galerie Canesso), Michel Descours (Librairie Michel Descours), Bertrand Gauthier et Bertrand Talabardon, Nicolas Joly (Sothedy's), Fabrizio Lemme, Hubert Prouté (Galerie Hubert Prouté), Giovanni Sarti (Galerie G. Sarti), Éric Turquin (Éric Turquin S.A.) et Marco Voen