Shock tube instrumentation techniques for study of hypervelocity entry problems

Shock tube instrumentation methods for convective heat transfer study and radiative properties of high temperature gas at conditions simulating hypervelocity entr

Experimental study of equilibrium air total radiation

Experimental study of equilibrium air total radiatio

Hypervelocity heat transfer studies in simulated planetary atmospheres final report

Hypervelocity heat transfer studies in simulated planetary atmosphere

Study of equilibrium air total radiation

Equilibrium radiation in air and gas mixtures assumed to represent near planet atmosphere

Shock tube techniques for studies of high temperature gas radiance

Techniques for measurement of equilibrium and non equilibrium radiance of high temperature gases in electric driven shock tub

Laboratory simulation of hypervelocity heat transfer problem during planetary entry

Laboratory simulation of hypervelocity heat transfer problem during planetary entr

A personalized platform identifies trametinib plus zoledronate for a patient with KRAS-mutant metastatic colorectal cancer

Colorectal cancer remains a leading source of cancer mortality worldwide. Initial response is often followed by emergent resistance that is poorly responsive to targeted therapies, reflecting currently undruggable cancer drivers such as KRAS and overall genomic complexity. Here, we report a novel approach to developing a personalized therapy for a patient with treatment-resistant metastatic KRAS-mutant colorectal cancer. An extensive genomic analysis of the tumor's genomic landscape identified nine key drivers. A transgenic model that altered orthologs of these nine genes in the Drosophila hindgut was developed; a robotics-based screen using this platform identified trametinib plus zoledronate as a candidate treatment combination. Treating the patient led to a significant response: Target and nontarget lesions displayed a strong partial response and remained stable for 11 months. By addressing a disease's genomic complexity, this personalized approach may provide an alternative treatment option for recalcitrant disease such as KRAS-mutant colorectal cancer

Risk model complex and connected infrastructure systems

Autorzy podejmują próbę zastosowania modelu przepływów międzygałęziowych Leontiefa do wykazania i określania ryzyka niezadziałania, powiązanych z sobą, elementów infrastruktury technicznej danego obszaru, bez wskazywania na jego rodzaj (miejski, wiejski). Określają za Leontiefem pojęcie niezdatności. Po krótkim, lecz wystarczającym opisie samej metody i zdefiniowaniu alternatyw systemu, rozwiązują dwa przykłady liczbowe, podając niezbędny aparat matematyczny, który może być stosowany w praktyce.The authors attempt to apply the Leontief’s interindustry flow model to demonstrate and determine the risk of not working of connected elements of technical infrastructure in individual area, without pointing to its kind (rural or municipal area). They determine the unfitness notion according to Leontief. Following a brief but adequate description of the method and defining the system alternative, the Authors solve two numerical examples providing the necessary mathematical apparatus which may be used in practice