12 research outputs found

    Polymer antibiotics

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    MEANS AND METHODS FOR PRODUCING POLYMERS COMPRISING PEPTIDE IN A SIDE CHAIN

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    The invention provides means and methods for producing polymers via mediated radical polymerisation wherein monomers comprising peptides in a side chain are polymerised. One of the applications of such polymers is the coating of surfaces with antibacterial (cyclic) peptides

    IgG1 + ovalbumin-specific B-cell transnuclear mice show class switch recombination in rare allelically included B cells

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    10.1073/pnas.1210273109Proceedings of the National Academy of Sciences of the United States of America1093413739-13744PNAS

    Design and Validation of Conditional Ligands for HLA-B*08:01, HLA-B*15:01, HLA-B*35:01, and HLA-B*44:05

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    Immunobiology of allogeneic stem cell transplantation and immunotherapy of hematological disease

    Structural and biological evaluation of some loloatin C analogues

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    Loloatin C is a cyclic cationic antimicrobial peptide which is active against Gram positive as well as certain Gram negative bacteria. Unfortunately, it is equally potent against human erythrocytes. To probe the structure-activity relationship of this promising antibiotic peptide, amino acid substitution and/or incorporation of a constraint sugar amino acid dipeptide isoster has been applied. Six new derivatives have been synthesized using SPPS and their solution structure investigated using NMR studies. Finally, the antimicrobial and the hemolytic activities have been determined. © 2009 Elsevier Ltd. All rights reserved
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