2,184 research outputs found
Spectropolarimetric observations of the Ca II 8498 A and 8542 A lines in the quiet Sun
The Ca II infrared triplet is one of the few magnetically sensitive
chromospheric lines available for ground-based observations. We present
spectropolarimetric observations of the 8498 A and 8542 A lines in a quiet Sun
region near a decaying active region and compare the results with a simulation
of the lines in a high plasma-beta regime. Cluster analysis of Stokes V profile
pairs shows that the two lines, despite arguably being formed fairly close,
often do not have similar shapes. In the network, the local magnetic topology
is more important in determining the shapes of the Stokes V profiles than the
phase of the wave, contrary to what our simulations show. We also find that
Stokes V asymmetries are very common in the network, and the histograms of the
observed amplitude and area asymmetries differ significantly from the
simulation. Both the network and internetwork show oscillatory behavior in the
Ca II lines. It is stronger in the network, where shocking waves, similar to
those in the high-beta simulation, are seen and large self-reversals in the
intensity profiles are common.Comment: 23 pages, 17 figures, accepted to ApJ some figures are low-res, for
high-res email [email protected]
Genetic variation in the oxytocin system and its link to social motivation in human infants
Frontal brain asymmetry has been linked to motivational processes in infants and adults, with left lateralization reflecting motivation to approach and right lateralization reflecting motivation to withdraw. We examined the hypothesis that variability in infantsâ social motivation may be linked to genetic variation in the oxytocin system. Eleven-month-old infantsâ brain responses and looking preferences to smiling and frowning individuals were assessed in conjunction with a polymorphism in CD38 (rs3796863) linked to autism spectrum disorder (ASD) and reduced oxytocin. Frontal brain asymmetry and looking preferences differed as a function of CD38 genotype. While non-risk A-allele carriers displayed left lateralization to smiling faces (approach) and a heightened looking preference for the individual who smiled, infants with the CC (ASD risk) genotype displayed withdrawal from smiling faces and a preference for the individual who frowned. Findings demonstrate that the oxytocin system is linked to brain and behavioral markers of social motivation in infancy
A human colonic crypt culture system to study regulation of stem cell-driven tissue renewal and physiological function
The intestinal epithelium is one of the most rapidly renewing tissues in the human body and fulfils vital physiological roles such as barrier function and transport of nutrients and fluid. Investigation of gut epithelial physiology in health and disease has been hampered by the lack of ex vivo models of the native human intestinal epithelium. Recently, remarkable progress has been made in defining intestinal stem cells and in generating intestinal organoid cultures. In parallel, we have developed a 3D culture system of the native human colonic epithelium that recapitulates the topological hierarchy of stem cell-driven tissue renewal and permits the physiological study of native polarized epithelial cells. Here we describe methods to establish 3D cultures of intact human colonic crypts and conduct real-time imaging of intestinal tissue renewal, cellular signalling, and physiological function, in conjunction with manipulation of gene expression by lentiviral or adenoviral transduction. Visualization of mRNA- and protein-expression patterns in cultured human colonic crypts, and cross-validation with crypts derived from fixed mucosal biopsies, is also described. Alongside studies using intestinal organoids, the near-native human colonic crypt culture model will help to bridge the gap that exists between investigation of colon cancer cell lines and/or animal (tissue) studies, and progression to clinical trials. To this end, the near native human colonic crypt model provides a platform to aid the development of novel strategies for the prevention of inflammatory bowel disease and cancer
Infant cortex responds to other humans from shortly after birth
A significant feature of the adult human brain is its ability to selectively process information about conspecifics. Much debate has centred on whether this specialization is primarily a result of phylogenetic adaptation, or whether the brain acquires expertise in processing social stimuli as a result of its being born into an intensely social environment. Here we study the haemodynamic response in cortical areas of newborns (1â5 days old) while they passively viewed dynamic human or mechanical action videos. We observed activation selective to a dynamic face stimulus over bilateral posterior temporal cortex, but no activation in response to a moving human arm. This selective activation to the social stimulus correlated with age in hours over the first few days post partum. Thus, even very limited experience of face-to-face interaction with other humans may be sufficient to elicit social stimulus activation of relevant cortical regions
Longitudinal Structure Functions in Decaying and Forced Turbulence
In order to reliably compute the longitudinal structure functions in decaying
and forced turbulence, local isotropy is examined with the aid of the isotropic
expression of the incompressible conditions for the second and third order
structure functions. Furthermore, the Karman-Howarth-Kolmogorov relation is
investigated to examine the effects of external forcing and temporally
decreasing of the second order structure function. On the basis of these
investigations, the scaling range and exponents of the longitudinal
structure functions are determined for decaying and forced turbulence with the
aid of the extended-self-similarity (ESS) method. We find that 's are
smaller, for , in decaying turbulence than in forced turbulence. The
reasons for this discrepancy are discussed. Analysis of the local slopes of the
structure functions is used to justify the ESS method.Comment: 15 pages, 16 figure
Deceptive signals of phase transitions in small magnetic clusters
We present an analysis of the thermodynamic properties of small transition
metal clusters and show how the commonly used indicators of phase transitions
like peaks in the specific heat or magnetic susceptibility can lead to
deceptive interpretations of the underlying physics. The analysis of the
distribution of zeros of the canonical partition function in the whole complex
temperature plane reveals the nature of the transition. We show that signals in
the magnetic susceptibility at positive temperatures have their origin at zeros
lying at negative temperatures.Comment: 4 pages, 5 figures, revtex4, for further information see
http://www.smallsystems.d
Bose-Einstein condensation in arbitrarily shaped cavities
We discuss the phenomenon of Bose-Einstein condensation of an ideal
non-relativistic Bose gas in an arbitrarily shaped cavity. The influence of the
finite extension of the cavity on all thermodynamical quantities, especially on
the critical temperature of the system, is considered. We use two main methods
which are shown to be equivalent. The first deals with the partition function
as a sum over energy levels and uses a Mellin-Barnes integral representation to
extract an asymptotic formula. The second method converts the sum over the
energy levels to an integral with a suitable density of states factor obtained
from spectral analysis. The application to some simple cavities is discussed.Comment: 10 pages, LaTeX, to appear in Physical Review
Current Switch by Coherent Trapping of Electrons in Quantum Dots
We propose a new transport mechanism through tunnel-coupled quantum dots
based on the coherent population trapping effect. Coupling to an excited level
by the coherent radiation of two microwaves can lead to an extremely narrow
current antiresonance. The effect can be used to determine interdot dephasing
rates and is a mechanism for a very sensitive, optically controlled current
switch.Comment: to appear in Phys. Rev. Let
Classification of phase transitions in small systems
We present a classification scheme for phase transitions in finite systems
like atomic and molecular clusters based on the Lee-Yang zeros in the complex
temperature plane. In the limit of infinite particle numbers the scheme reduces
to the Ehrenfest definition of phase transitions and gives the right critical
indices. We apply this classification scheme to Bose-Einstein condensates in a
harmonic trap as an example of a higher order phase transitions in a finite
system and to small Ar clusters.Comment: 12 pages, 4 figures, accepted for publication in Phys. Rev. Let
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