Characterization and functional roles of paternal RNAs in 2–4 cell bovine embryos

Embryos utilize oocyte-donated RNAs until they become capable of producing RNAs through embryonic genome activation (EGA). The sperm\u2019s influence over pre-EGA RNA content of embryos remains unknown. Recent studies have revealed that sperm donate non-genomic components upon fertilization. Thus, sperm may also contribute to RNA presence in pre-EGA embryos. The first objective of this study was to investigate whether male fertility status is associated with the RNAs present in the bovine embryo prior to EGA. A total of 65 RNAs were found to be differentially expressed between 2\u20134 cell bovine embryos derived from high and low fertility sires. Expression patterns were confirmed for protein phosphatase 1 regulatory subunit 36 (PPP1R36) and ataxin 2 like (ATXN2L) in three new biological replicates. The knockdown of ATXN2L led to a 22.9% increase in blastocyst development. The second objective of this study was to characterize the parental origin of RNAs present in pre-EGA embryos. Results revealed 472 sperm-derived RNAs, 2575 oocyte-derived RNAs, 2675 RNAs derived from both sperm and oocytes, and 663 embryo-exclusive RNAs. This study uncovers an association of male fertility with developmentally impactful RNAs in 2\u20134 cell embryos. This study also provides an initial characterization of paternally-contributed RNAs to pre-EGA embryos. Furthermore, a subset of 2\u20134 cell embryo-specific RNAs was identified

On the Rigorous Derivation of the 3D Cubic Nonlinear Schr\"odinger Equation with A Quadratic Trap

We consider the dynamics of the 3D N-body Schr\"{o}dinger equation in the presence of a quadratic trap. We assume the pair interaction potential is N^{3{\beta}-1}V(N^{{\beta}}x). We justify the mean-field approximation and offer a rigorous derivation of the 3D cubic NLS with a quadratic trap. We establish the space-time bound conjectured by Klainerman and Machedon [30] for {\beta} in (0,2/7] by adapting and simplifying an argument in Chen and Pavlovi\'c [7] which solves the problem for {\beta} in (0,1/4) in the absence of a trap.Comment: Revised according to the referee report. Accepted to appear in Archive for Rational Mechanics and Analysi

Second-order corrections to mean field evolution for weakly interacting Bosons. I

Inspired by the works of Rodnianski and Schlein and Wu, we derive a new nonlinear Schr\"odinger equation that describes a second-order correction to the usual tensor product (mean-field) approximation for the Hamiltonian evolution of a many-particle system in Bose-Einstein condensation. We show that our new equation, if it has solutions with appropriate smoothness and decay properties, implies a new Fock space estimate. We also show that for an interaction potential $v(x)= \epsilon \chi(x) |x|^{-1}$, where $\epsilon$ is sufficiently small and $\chi \in C_0^{\infty}$, our program can be easily implemented locally in time. We leave global in time issues, more singular potentials and sophisticated estimates for a subsequent part (part II) of this paper

Inhomogeneous chiral symmetry breaking in noncommutative four fermion interactions

The generalization of the Gross-Neveu model for noncommutative 3+1 space-time has been analyzed. We find indications that the chiral symmetry breaking occurs for an inhomogeneous background as in the LOFF phase in condensed matter.Comment: 17 pages, 2 figures, published version, minor correction

Two-Step Model of Fusion for Synthesis of Superheavy Elements

A new model is proposed for fusion mechanisms of massive nuclear systems where so-called fusion hindrance exists. The model describes two-body collision processes in an approaching phase and shape evolutions of an amalgamated system into the compound nucleus formation. It is applied to $^{48}$Ca-induced reactions and is found to reproduce the experimental fusion cross sections extremely well, without any free parameter. Combined with the statistical decay theory, residue cross sections for the superheavy elements can be readily calculated. Examples are given.Comment: 4 pages, 4 figure

Relativistic instant-form approach to the structure of two-body composite systems

A new approach to the electroweak properties of two-particle composite systems is developed. The approach is based on the use of the instant form of relativistic Hamiltonian dynamics. The main novel feature of this approach is the new method of construction of the matrix element of the electroweak current operator. The electroweak current matrix element satisfies the relativistic covariance conditions and in the case of the electromagnetic current also the conservation law automatically. The properties of the system as well as the approximations are formulated in terms of form factors. The approach makes it possible to formulate relativistic impulse approximation in such a way that the Lorentz-covariance of the current is ensured. In the electromagnetic case the current conservation law is ensured, too. The results of the calculations are unambiguous: they do not depend on the choice of the coordinate frame and on the choice of "good" components of the current as it takes place in the standard form of light--front dynamics. Our approach gives good results for the pion electromagnetic form factor in the whole range of momentum transfers available for experiments at present time, as well as for lepton decay constant of pion.Comment: 26 pages, Revtex, 5 figure

Scalar Solitons on the Fuzzy Sphere

We study scalar solitons on the fuzzy sphere at arbitrary radius and noncommutativity. We prove that no solitons exist if the radius is below a certain value. Solitons do exist for radii above a critical value which depends on the noncommutativity parameter. We construct a family of soliton solutions which are stable and which converge to solitons on the Moyal plane in an appropriate limit. These solutions are rotationally symmetric about an axis and have no allowed deformations. Solitons that describe multiple lumps on the fuzzy sphere can also be constructed but they are not stable.Comment: 24 pages, 2 figures, typo corrected and stylistic changes. v3: reference adde

Preparation of decoherence-free, subradiant states in a cavity

The cause of decoherence in a quantum system can be traced back to the interaction with the environment. As it has been pointed out first by Dicke, in a system of N two-level atoms where each of the atoms is individually dipole coupled to the environment, there are collective, subradiant states, that have no dipole coupling to photon modes, and therefore they are expected to decay slower. This property also implies that these type of states, which form an N-1 dimensional subspace of the atomic subsytem, also decohere slower. We propose a scheme which will create such states. First the two-level atoms are placed in a strongly detuned cavity and one of the atoms, called the control atom is excited. The time evolution of the coupled atom-cavity system leads to an appropriately entangled state of the atoms. By applying subsequent laser pulses at a well defined time instant, it is possible to drive the atomic state into the subradiant, i. e., decoherence free subspace. Up to a certain average number of the photons, the result is independent of the state of the cavity. The analysis of the conditions shows that this scheme is feasible with present day techniques achieved in atom cavity interaction experiments.Comment: 5 page

Magnetism in a lattice of spinor Bose condensates

We study the ground state magnetic properties of ferromagnetic spinor Bose-Einstein condensates confined in a deep optical lattices. In the Mott insulator regime, the ``mini-condensates'' at each lattice site behave as mesoscopic spin magnets that can interact with neighboring sites through both the static magnetic dipolar interaction and the light-induced dipolar interaction. We show that such an array of spin magnets can undergo a ferromagnetic or anti-ferromagnetic phase transition under the magnetic dipolar interaction depending on the dimension of the confining optical lattice. The ground-state spin configurations and related magnetic properties are investigated in detail

Magnetic catalysis and anisotropic confinement in QCD

The expressions for dynamical masses of quarks in the chiral limit in QCD in a strong magnetic field are obtained. A low energy effective action for the corresponding Nambu-Goldstone bosons is derived and the values of their decay constants as well as the velocities are calculated. The existence of a threshold value of the number of colors $N^{thr}_c$, dividing the theories with essentially different dynamics, is established. For the number of colors $N_c \ll N^{thr}_c$, an anisotropic dynamics of confinement with the confinement scale much less than $\Lambda_{QCD}$ and a rich spectrum of light glueballs is realized. For $N_c$ of order $N^{thr}_c$ or larger, a conventional confinement dynamics takes place. It is found that the threshold value $N^{thr}_c$ grows rapidly with the magnetic field [$N^{thr}_c \gtrsim 100$ for $|eB| \gtrsim (1{GeV})^2$]. In contrast to QCD with a nonzero baryon density, there are no principal obstacles for checking these results and predictions in lattice computer simulations.Comment: 10 pages, 1 figure. REVTeX. Minor correction. To appear in Phys. Rev.