Comparaison du polymorphisme génétique des lactoprotéines du zébu et des bovins

International audienc

Mechanical Performance of Short Models for MQXF, the Nb3Sn Low-β Quadrupole for the Hi-Lumi LHC

In the framework of the Hi-Lumi LHC Project, CERN and U.S. LARP are jointly developing MQXF, a 150-mm aperture high-field Nb3Sn quadrupole for the upgrade of the inner triplet of the low-beta interaction regions. The magnet is supported by a shell-based structure, providing the preload by means of bladder-key technology and differential thermal contraction of the various components. Two short models have been produced using the same cross section currently considered for the final magnet. The structures were preliminarily tested replacing the superconducting coils with blocks of aluminum. This procedure allows for model validation and calibration, and also to set performance goals for the real magnet. Strain gauges were used to monitor the behavior of the structure during assembly, cool down and also excitation in the case of the magnets. The various structures differ for the shell partitioning strategies adopted and for the presence of thick or thin laminations. This paper presents the results obtained and discusses the mechanical performance of all the short models produced up to now

Adverse childhood experiences and premature all-cause mortality

Events causing stress responses during sensitive periods of rapid neurological development in childhood may be early determinants of all-cause premature mortality. Using a British birth cohort study of individuals born in 1958, the relationship between adverse childhood experiences (ACE) and mortality ≤50 year was examined for men (n = 7,816) and women (n = 7,405) separately. ACE were measured using prospectively collected reports from parents and the school: no adversities (70 %); one adversity (22 %), two or more adversities (8 %). A Cox regression model was carried out controlling for early life variables and for characteristics at 23 years. In men the risk of death was 57 % higher among those who had experienced 2+ ACE compared to those with none (HR 1.57, 95 % CI 1.13, 2.18, p = 0.007). In women, a graded relationship was observed between ACE and mortality, the risk increasing as ACE accumulated. Women with one ACE had a 66 % increased risk of death (HR 1.66, 95 % CI 1.19, 2.33, p = 0.003) and those with ≥2 ACE had an 80 % increased risk (HR 1.80, 95 % CI 1.10, 2.95, p = 0.020) versus those with no ACE. Given the small impact of adult life style factors on the association between ACE and premature mortality, biological embedding during sensitive periods in early development is a plausible explanatory mechanism

Accused of an "abominable crime": punishing homosexual blackmail threats in London, 1723–1823

For much of the eighteenth- and early nineteenth-century, the criminal justice system in the United Kingdom operated under “the Bloody Code” in which more than 200 crimes were punishable by death. Despite the apparent severity of this punitive system, the laws around extortion during this period were ambiguous and unclear. Drawing on records from London’s Old Bailey over the century from 1723 to 1823, this research examines the specific offence of threatening to accuse a person of criminalised homosexual acts for the purposes of extortion. Drawing on a range of cases in London over a century, this research examines the varying judicial treatment of crimes committed in person versus extortion conducted in written form — a major distinction under the conditions of the Bloody Code. It highlights the inconsistency in the application of the law, as well as presenting potential explanations as to why similar crimes were punished so differently in Georgian Britain. Based on case file analysis, it comes to an intriguing conclusion about how these cases were handled by the Old Bailey, coming to the conclusion that sentences for homosexual extortion attempts were often mitigated in cases where there was a question as to whether the victim was, in reality, a gay man. This conclusion has serious implications for our understanding of the nexus between homosexuality and the English legal system in this complex period