16 research outputs found
Polymorphism: an evaluation of the potential risk to the quality of drug products from the FarmĂĄcia Popular Rede PrĂłpria
Polymorphism in solids is a common phenomenon in drugs, which can lead to compromised quality due to changes in their physicochemical properties, particularly solubility, and, therefore, reduce bioavailability. Herein, a bibliographic survey was performed based on key issues and studies related to polymorphism in active pharmaceutical ingredient (APIs) present in medications from the Farmácia Popular Rede Própria. Polymorphism must be controlled to prevent possible ineffective therapy and/or improper dosage. Few mandatory tests for the identification and control of polymorphism in medications are currently available, which can result in serious public health concerns
Experience, narrative and interaction in TV-centred communication
Based on the view that changes in user expectations and social demographics alter the traditional use of TV this paper investigates the notion of experience, narrative and interaction in TV-centred communication. We have a look at synchronous and asynchronous consumption of expert as well as user-generated content. We then investigate participatory elements that enhance the feeling of social belonging and togetherness in particular when TV users are separated by time and space
Approximation-based integral versus differential isoconversional approaches to the evaluation of kinetic parameters from thermogravimetry: kinetic analysis of the dehydration of a pharmaceutical hydrate
The relative accuracies of approximation-based
integral versus differential isoconversional approaches for
âactualâ E determination were investigated on experimental
dehydration data of roxithromycin monohydrate from
thermogravimetric (TG) analysis. The dehydration kinetic
parameters and the relationship to the structural characteristics
of the monohydrate and anhydrate forms from
differential scanning calorimetry (DSC) and single-crystal
X-ray diffractometry (SC-XRD) are also reported. Integral
methods versus the differential Friedman isoconversional
method evaluated E correspondences in both iso- and nonisothermal
TG methods. The reliability in E from Friedman
approached that of estimates from current most accepted
integral isoconversional methods and was even superior to
methods (for non-isothermal studies) that employ an
approximation to the temperature integral (modified Kissingerâ
AkahiraâSunose, SenumâYang fourth degree).
Structural characterization (DSC, SC-XRD) and kinetic
analysis from generalized kinetic master plots concluded
that coordinated water occupied interlinked voids in crystal
structure which may have facilitated the multidimensional
diffusional loss of water upon heating without disruption of
the crystal structureNelson Mandela
Metropolitan University (NMMU); National Research Foundation
(NRF