1,209 research outputs found
The biting and predaceous midges of Guadeloupe (Diptera: Ceratopogonidae). I. Species of the subfamily Ceratopogoninae
We provide new records of biting and predaceous midges (Diptera: Ceratopogonidae) from Guadeloupe in the subfamily Ceratopogoninae, including descriptions and illustrations of three new predaceous species in the genera, Parabezzia Malloch, Stilobezzia Kieffer and Palpomyia Meigen, respectively, and the first records of the New World predaceous genus, Amerohelea Grogan and Wirth, from the Caribbean region. We also provide the first Guadeloupe records of the biting midges, Culicoides (Anilomyia) decor (Williston), C. (Avaritia) pusillus Lutz, C. (Drymodesmyia) bredini Wirth and Blanton, C. (D.) poikilonotus Macfie, C. (Haematomyidium) hoffmani Fox, C. (Hoffmania) insignis Lutz, C. rangeli Ortiz and Mirsa and C. trilineatus Fox, and the predaceous midges, Brachypogon (Brachypogon) bifidus Spinelli and Grogan, B. (B.) telesfordi Spinelli and Grogan, B. (B.) woodruffi Spinelli and Grogan, Monohelea maya Felippe-Bauer, Huerta and Ibåñez-Bernal, Stilobezzia (Stilobezzia) diminuta Lane and Forattini, S. (S.) thomsenae Wirth, Amerohelea galindoi Grogan and Wirth, Bezzia (Bezzia) flinti Spinelli and Wirth, B. (Homobezzia) venustula (Williston) and Palpomyia insularis Spinelli and Grogan
How Observations of Circumstellar Disk Asymmetries Can Reveal Hidden Planets: Pericenter Glow and its Application to the HR 4796 Disk
Recent images of the disks of dust around the young stars HR 4796A and
Fomalhaut show, in each case, a double-lobed feature that may be asymmetric
(one lobe may be brighter than the other). A symmetric double-lobed structure
is that expected from a disk of dust with a central hole that is observed
nearly edge-on (i.e., close to the plane of the disk). This paper shows how the
gravitational influence of a second body in the system with an eccentric orbit
would cause a brightness asymmetry in such a disk by imposing a "forced
eccentricity" on the orbits of the constituent dust particles, thus shifting
the center of symmetry of the disk away from the star and causing the dust near
the forced pericenter of the perturbed disk to glow. Dynamic modeling of the HR
4796 disk shows that its 5% brightness asymmetry could be the result of a
forced eccentricity as small as 0.02 imposed on the disk by either the binary
companion HR 4796B, or by an unseen planet close to the inner edge of the disk.
Since it is likely that a forced eccentricity of 0.01 or higher would be
imposed on a disk in a system in which there are planets, but no binary
companion, the corresponding asymmetry in the disk's structure could serve as a
sensitive indicator of these planets that might otherwise remain undetected.Comment: 61 pages, 10 figures, accepted for publication in the Astrophysical
Journal (scheduled for January 10, 2000
Dopamine promotes instrumental motivation, but reduces reward-related vigour.
We can be motivated when reward depends on performance, or merely by the prospect of a guaranteed reward. Performance-dependent (contingent) reward is instrumental, relying on an internal action-outcome model, whereas motivation by guaranteed reward may minimise opportunity cost in reward-rich environments. Competing theories propose that each type of motivation should be dependent on dopaminergic activity. We contrasted these two types of motivation with a rewarded saccade task, in patients with Parkinson's disease (PD). When PD patients were ON dopamine, they had greater response vigour (peak saccadic velocity residuals) for contingent rewards, whereas when PD patients were OFF medication, they had greater vigour for guaranteed rewards. These results support the view that reward expectation and contingency drive distinct motivational processes, and can be dissociated by manipulating dopaminergic activity. We posit that dopamine promotes goal-directed motivation, but dampens reward-driven vigour, contradictory to the prediction that increased tonic dopamine amplifies reward expectation
Spitzer Mid-IR Spectra of Dust Debris Around A and Late B Type Stars: Asteroid Belt Analogs and Power-Law Dust Distributions
Using the Spitzer/Infrared Spectrograph (IRS) low-resolution modules covering wavelengths from 5 to 35 ÎŒm, we observed 52 main-sequence A and late B type stars previously seen using Spitzer/Multiband Imaging Photometer (MIPS) to have excess infrared emission at 24 ÎŒm above that expected from the stellar photosphere. The mid-IR excess is confirmed in all cases but two. While prominent spectral features are not evident in any of the spectra, we observed a striking diversity in the overall shape of the spectral energy distributions. Most of the IRS excess spectra are consistent with single-temperature blackbody emission, suggestive of dust located at a single orbital radiusâa narrow ring. Assuming the excess emission originates from a population of large blackbody grains, dust temperatures range from 70 to 324 K, with a median of 190 K corresponding to a distance of 10 AU. Thirteen stars however, have dust emission that follows a power-law distribution, F_Îœ = F 0λ^α, with exponent α ranging from 1.0 to 2.9. The warm dust in these systems must span a greater range of orbital locationsâan extended disk. All of the stars have also been observed with Spitzer/MIPS at 70 ÎŒm, with 27 of the 50 excess sources detected (signal-to-noise ratio > 3). Most 70 ÎŒm fluxes are suggestive of a cooler, Kuiper Belt-like component that may be completely independent of the asteroid belt-like warm emission detected at the IRS wavelengths. Fourteen of 37 sources with blackbody-like fits are detected at 70 ÎŒm. The 13 objects with IRS excess emission fit by a power-law disk model, however, are all detected at 70 ÎŒm (four above, three on, and six below the extrapolated power law), suggesting that the mid-IR IRS emission and far-IR 70 ÎŒm emission may be related for these sources. Overall, the observed blackbody and power-law thermal profiles reveal debris distributed in a wide variety of radial structures that do not appear to be correlated with spectral type or stellar age. An additional 43 fainter A and late B type stars without 70 ÎŒm photometry were also observed with Spitzer/IRS; results are summarized in Appendix B
A new species of predaceous midge in the Patagonian genus Austrosphaeromias with a redescription of A. chilensis (Diptera, Ceratopogonidae)
Silicon microcantilever sensors to detect the reversible conformational change of a molecular switch, Spiropyan
The high sensitivity of silicon microcantilever sensors has expanded their use in areas ranging from gas sensing to bio-medical applications. Photochromic molecules also represent promising candidates for a large variety of sensing applications. In this work, the operating principles of these two sensing methods are combined in order to detect the reversible conformational change of a molecular switch, spiropyran. Thus, arrays of silicon microcantilever sensors were functionalized with spiropyran on the gold covered side and used as test microcantilevers. The microcantilever deflection response was observed, in five sequential cycles, as the transition from the spiropyran (SP) (CLOSED) to the merocyanine (MC) (OPEN) state and vice-versa when induced by UV and white light LED sources, respectively, proving the reversibility capabilities of this type of sensor. The microcantilever deflection direction was observed to be in one direction when changing to the MC state and in the opposite direction when changing back to the SP state. A tensile stress was induced in the microcantilever when the SP to MC transition took place, while a compressive stress was observed for the reverse transition. These different type of stresses are believed to be related to the spatial conformational changes induced in the photochromic molecule upon photo-isomerisation
New Debris Disks Around Nearby Main Sequence Stars: Impact on The Direct Detection of Planets
Using the MIPS instrument on the Spitzer telescope, we have searched for
infrared excesses around a sample of 82 stars, mostly F, G, and K main-sequence
field stars, along with a small number of nearby M stars. These stars were
selected for their suitability for future observations by a variety of
planet-finding techniques. These observations provide information on the
asteroidal and cometary material orbiting these stars - data that can be
correlated with any planets that may eventually be found. We have found
significant excess 70um emission toward 12 stars. Combined with an earlier
study, we find an overall 70um excess detection rate of % for mature
cool stars. Unlike the trend for planets to be found preferentially toward
stars with high metallicity, the incidence of debris disks is uncorrelated with
metallicity. By newly identifying 4 of these stars as having weak 24um excesses
(fluxes 10% above the stellar photosphere), we confirm a trend found in
earlier studies wherein a weak 24um excess is associated with a strong 70um
excess. Interestingly, we find no evidence for debris disks around 23 stars
cooler than K1, a result that is bolstered by a lack of excess around any of
the 38 K1-M6 stars in 2 companion surveys. One motivation for this study is the
fact that strong zodiacal emission can make it hard or impossible to detect
planets directly with future observatories like the {\it Terrestrial Planet
Finder (TPF)}. The observations reported here exclude a few stars with very
high levels of emission, 1,000 times the emission of our zodiacal cloud,
from direct planet searches. For the remainder of the sample, we set relatively
high limits on dust emission from asteroid belt counterparts
Gender and educational leadership in England: a comparison of secondary headteachers' views over time
In the context of gender being a barrier to accessing leadership, this paper presents a comparison of the views of men and women head teacher (principals) of secondary schools in England in the 1990s and in 2004. The same survey instrument was used on both occasions. The perceptions of the head teachers show change in some areas and no change in others. Overall, women are more likely to become head teachers and are now less likely to be categorised into pastoral roles, but in some cases women still meet prejudice from governors and others in the wider community. Women head teachers are more likely to have partners and children than in the 1990s, sharing equally or carrying most of the domestic responsibilities, whereas male colleagues are most likely to have partners who take the majority of responsibility in the home. Essentialist stereotypes about women and men as leaders still prevail, although both the women and men head teachers see themselves as adopting a traditionally âfeminineâ style of leadership. Women head teachers are likely to see some benefits in being a woman in a role stereotypically associated with men. However, there has been an increase in the proportion of women who feel that they have to prove their worth as a leader, and this may be linked with increased levels of accountability in schools
Outcomes by Cardiac Stage in Patients With Newly Diagnosed AL Amyloidosis: Phase 3 ANDROMEDA Trial
BACKGROUND:
Patients with amyloid light chain amyloidosis and severe cardiac dysfunction have a poor prognosis. Treatment options that induce rapid and deep hematologic and organ responses, irrespective of cardiac involvement, are needed.
OBJECTIVES:
The aim of this study was to evaluate the impact of baseline cardiac stage on efficacy and safety outcomes in the phase 3 ANDROMEDA trial.
METHODS:
Rates of overall complete hematologic response and cardiac and renal response at 6 months and median major organ deteriorationâprogression-free survival and major organ deteriorationâevent-free survival were compared across cardiac stages (I, II, or IIIA) and treatments (daratumumab, bortezomib, cyclophosphamide, and dexamethasone [D-VCd] or bortezomib, cyclophosphamide, and dexamethasone [VCd]). Rates of adverse events (AEs) were summarized for patients with and without baseline cardiac involvement and by cardiac stage.
RESULTS:
Median follow-up duration was 15.7 months. The proportions of stage I, II, and IIIA patients were 23.2%, 40.2%, and 36.6%. Across cardiac stages, hematologic and organ response rates were higher and major organ deteriorationâprogression-free survival and major organ deteriorationâevent-free survival were longer with D-VCd than VCd. AE rates were similar between treatments and by cardiac stage; serious AE rates were higher in patients with cardiac involvement and increased with increasing cardiac stage. The incidence of cardiac events was numerically greater with D-VCd vs VCd, but the rate of grade 3 or 4 events was similar. The exposure-adjusted incidence rate for cardiac events was lower with D-VCd than VCd (median exposure 13.4 and 5.3 months, respectively).
CONCLUSIONS:
These findings demonstrate the efficacy of D-VCd over VCd in patients with newly diagnosed amyloid light chain amyloidosis across cardiac stages, thus supporting its use in patients with cardiac involvement. (NCT03201965
Integration of a 3D hydrogel matrix within a hollow core photonic crystal fibre for DNA probe immobilization
In this paper, we demonstrate the integration of a 3D hydrogel matrix within a hollow core photonic crystal fibre (HC-PCF). In addition, we also show the fluorescence of Cy5-labelled DNA molecules immobilized within the hydrogel formed in two different types of HC-PCF. The 3D hydrogel matrix is designed to bind with the amino groups of biomolecules using an appropriate cross-linker, providing higher sensitivity and selectivity than the standard 2D coverage, enabling a greater number of probe molecules to be available per unit area. The HC-PCFs, on the other hand, can be designed to maximize the capture of fluorescence to improve sensitivity and provide longer interaction lengths. This could enable the development of fibre-based point-of-care and remote systems, where the enhanced sensitivity would relax the constraints placed on sources and detectors. In this paper, we will discuss the formation of such polyethylene glycol diacrylate (PEGDA) hydrogels within a HC-PCF, including their optical properties such as light propagation and auto-fluorescence
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