408 research outputs found
Phase transition curves for mesoscopic superconducting samples
We compute the phase transition curves for mesoscopic superconductors.
Special emphasis is given to the limiting shape of the curve when the magnetic
flux is large. We derive an asymptotic formula for the ground state of the
Schr\"odinger equation in the presence of large applied flux. The expansion is
shown to be sensitive to the smoothness of the domain. The theoretical results
are compared to recent experiments.Comment: 8 pages, 1 figur
Flux-Induced Vortex in Mesoscopic Superconducting Loops
We predict the existence of a quantum vortex for an unusual situation. We
study the order parameter in doubly connected superconducting samples embedded
in a uniform magnetic field. For samples with perfect cylindrical symmetry, the
order parameter has been known for long and no vortices are present in the
linear regime. However, if the sample is not symmetric, there exist ranges of
the field for which the order parameter vanishes along a line, parallel to the
field. In many respects, the behavior of this line is qualitatively different
from that of the vortices encountered in type II superconductivity. For samples
with mirror symmetry, this flux-induced vortex appears at the thin side for
small fluxes and at the opposite side for large fluxes. We propose direct and
indirect experimental methods which could test our predictions.Comment: 6 pages, Latex, 4 figs., uses RevTex, extended to situations far from
cylindrical symmetr
Response to the COVID-19 Pandemic Among Posthospital Brain Injury Rehabilitation Providers
Rehabilitation after significant acquired brain injury (ABI) to address complex independent activities of daily living and return to family and community life is offered primarily after initial hospitalization in outpatient day treatment, group home, skilled nursing, and residential settings and in the home and community of the person served. The coronavirus 2019 pandemic threatened access to care and the health and safety of staff, persons served, and families in these settings. This article describes steps taken to contain this threat by 7 leading posthospital ABI rehabilitation organizations. Outpatient and day treatment facilities were temporarily suspended. In other settings, procedures for isolation, transportation, cleaning, exposure control, infection control, and use of personal protective equipment (PPE) were reinforced with staff. Visitation and community activities were restricted. Staff and others required to enter facilities were screened with symptom checklists and temperature checks. Individuals showing symptoms of infection were quarantined and tested, as possible. New admissions were carefully screened for infection and often initially quarantined. Telehealth played a major role in reducing direct interpersonal contact while continuing to provide services both to outpatients and within facilities. Salary, benefits, training, and managerial support were enhanced for staff. Despite early outbreaks, these procedures were generally effective, with preliminary initial infections rates of only 1.1% for persons served and 2.1% for staff. Reductions in admissions, services, and unanticipated expenses (eg, PPE, more frequent and thorough cleaning) had a major negative financial effect. Providers continue to be challenged to adapt rehabilitative approaches and to reopen services.Supported by the Foundation for the Advancement of Brain Rehabilitation (FABR)
Nancy Grace Roman Space Telescope Coronagraph Instrument Overview and Status
The Nancy Grace Roman Space Telescope Coronagraph Instrument is a critical
technology demonstrator for NASA's Habitable Worlds Observatory. With a
predicted visible-light flux ratio detection limit of 1E-8 or better, it will
be capable of reaching new areas of parameter space for both gas giant
exoplanets and circumstellar disks. It is in the final stages of integration
and test at the Jet Propulsion Laboratory, with an anticipated delivery to
payload integration in the coming year. This paper will review the instrument
systems, observing modes, potential observing applications, and overall
progress toward instrument integration and test.Comment: Proceedings of SPIE: Techniques and Instrumentation for Detection of
Exoplanets XI, vol. 12680 (2023
Generation tourism: towards a common identity
The purpose of this article is to highlight the implications of the indiscipline of tourism academia for a new generation of tourism academics. Generation Tourism is characterised by scholars with a multi-disciplinary education associated with a broad field of study and commonly considered to lack the advantages of a discipline-focused education with its strong theoretical and methodological foundations. The problem this article addresses relates to how new generations of scholars and their views on knowledge creation achieve ascendancy in ways that move on from existing paradigms and earlier cohorts of scholars. Our main argument is that Generation Tourism scholars would benefit from a more clearly developed and common academic identity. To begin the critical conversation around the identity of Generation Tourism we outline five possible points of departure. These points are: (1) learning from historical developments in parent disciplines; (2) spearheading inter-disciplinary scholarship; (3) working towards theoretical developments; (4) embracing mediating methodologies and (5) forming tourism nodes and networks. Recognising these as starting points rather than final statements, we hope that the conversation about Generation Tourism identity will continue in other forums
Nancy Grace Roman Space Telescope Coronagraph Instrument Observation Calibration Plan
NASA's next flagship mission, the Nancy Grace Roman Space Telescope, is a
2.4-meter observatory set to launch no later than May 2027. Roman features two
instruments: the Wide Field Imager and the Coronagraph Instrument. Roman's
Coronagraph is a Technology Demonstration that will push the current
capabilities of direct imaging to smaller contrast ratios (10) and
inner-working angles (3~/D). In order to achieve this high precision,
Roman Coronagraph data must be calibrated to remove as many potential sources
of error as possible. Here we present a detailed overview of the Nancy Grace
Roman Space Telescope Coronagraph Instrument Observation Calibration Plan
including identifying potential sources of error and how they will be mitigated
via on-sky calibrations.Comment: Posting for public information on the current status of the Roman
Coronagraph Observation Calibration Plan; latest updates as of July 29, 202
The what and where of adding channel noise to the Hodgkin-Huxley equations
One of the most celebrated successes in computational biology is the
Hodgkin-Huxley framework for modeling electrically active cells. This
framework, expressed through a set of differential equations, synthesizes the
impact of ionic currents on a cell's voltage -- and the highly nonlinear impact
of that voltage back on the currents themselves -- into the rapid push and pull
of the action potential. Latter studies confirmed that these cellular dynamics
are orchestrated by individual ion channels, whose conformational changes
regulate the conductance of each ionic current. Thus, kinetic equations
familiar from physical chemistry are the natural setting for describing
conductances; for small-to-moderate numbers of channels, these will predict
fluctuations in conductances and stochasticity in the resulting action
potentials. At first glance, the kinetic equations provide a far more complex
(and higher-dimensional) description than the original Hodgkin-Huxley
equations. This has prompted more than a decade of efforts to capture channel
fluctuations with noise terms added to the Hodgkin-Huxley equations. Many of
these approaches, while intuitively appealing, produce quantitative errors when
compared to kinetic equations; others, as only very recently demonstrated, are
both accurate and relatively simple. We review what works, what doesn't, and
why, seeking to build a bridge to well-established results for the
deterministic Hodgkin-Huxley equations. As such, we hope that this review will
speed emerging studies of how channel noise modulates electrophysiological
dynamics and function. We supply user-friendly Matlab simulation code of these
stochastic versions of the Hodgkin-Huxley equations on the ModelDB website
(accession number 138950) and
http://www.amath.washington.edu/~etsb/tutorials.html.Comment: 14 pages, 3 figures, review articl
JWST/NIRCam Coronagraphy of the Young Planet-hosting Debris Disk AU Microscopii
High-contrast imaging of debris disk systems permits us to assess the
composition and size distribution of circumstellar dust, to probe recent
dynamical histories, and to directly detect and characterize embedded
exoplanets. Observations of these systems in the infrared beyond 2--3 m
promise access to both extremely favorable planet contrasts and numerous
scattered-light spectral features -- but have typically been inhibited by the
brightness of the sky at these wavelengths. We present coronagraphy of the AU
Microscopii (AU Mic) system using JWST's Near Infrared Camera (NIRCam) in two
filters spanning 3--5 m. These data provide the first images of the
system's famous debris disk at these wavelengths and permit additional
constraints on its properties and morphology. Conducting a deep search for
companions in these data, we do not identify any compelling candidates.
However, with sensitivity sufficient to recover planets as small as
Jupiter masses beyond ( au) with
confidence, these data place significant constraints on any massive companions
that might still remain at large separations and provide additional context for
the compact, multi-planet system orbiting very close-in. The observations
presented here highlight NIRCam's unique capabilities for probing similar disks
in this largely unexplored wavelength range, and provide the deepest direct
imaging constraints on wide-orbit giant planets in this very well studied
benchmark system.Comment: 27 pages, 14 figure
SCExAO/MEC and CHARIS Discovery of a Low Mass, 6 AU-Separation Companion to HIP 109427 using Stochastic Speckle Discrimination and High-Contrast Spectroscopy
We report the direct imaging discovery of a low-mass companion to the nearby
accelerating A star, HIP 109427, with the Subaru Coronagraphic Extreme Adaptive
Optics (SCExAO) instrument coupled with the MKID Exoplanet Camera (MEC) and
CHARIS integral field spectrograph. CHARIS data reduced with reference star PSF
subtraction yield 1.1-2.4 m spectra. MEC reveals the companion in and
band at a comparable signal-to-noise ratio using stochastic speckle
discrimination, with no PSF subtraction techniques. Combined with complementary
follow-up photometry from Keck/NIRC2, the SCExAO data favors a
spectral type, effective temperature, and luminosity of M4-M5.5, 3000-3200 ,
and , respectively.
Relative astrometry of HIP 109427 B from SCExAO/CHARIS and Keck/NIRC2, and
complementary Gaia-Hipparcos absolute astrometry of the primary favor a
semimajor axis of au, an eccentricity of
, an inclination of degrees, and a
dynamical mass of . This work shows the
potential for extreme AO systems to utilize speckle statistics in addition to
widely-used post-processing methods to directly image faint companions to
nearby stars near the telescope diffraction limit.Comment: 13 pages, 7 figures, 3 table
Viral trans-factor independent replication of human papillomavirus genomes
<p>Abstract</p> <p>Background</p> <p>Papillomaviruses (PVs) establish a persistent infection in the proliferating basal cells of the epithelium. The viral genome is replicated and maintained as a low-copy nuclear plasmid in basal keratinocytes. Bovine and human papillomaviruses (BPV and HPV) are known to utilize two viral proteins; E1, a DNA helicase, and E2, a transcription factor, which have been considered essential for viral DNA replication. However, growing evidence suggests that E1 and E2 are not entirely essential for stable replication of HPV.</p> <p>Results</p> <p>Here we report that multiple HPV16 mutants, lacking either or both E1 and E2 open reading frame (ORFs) and the long control region (LCR), still support extrachromosomal replication. Our data clearly indicate that HPV16 has a mode of replication, independent of viral trans-factors, E1 and E2, which is achieved by origin activity located outside of the LCR.</p
- …