Social Climate in the University Social System

Social climate (campus climate), which is defined as Equal Opportunity Climate, 1 has been deemed important by recent legislation requiring that federally funded institutions demonstrate a good faith effort to assess climate as an ongoing concern. The 1991 Civil Rights Act has expanded the working definition of social climate by including both the atmosphere and the behavior of discrimination. Social climate then becomes a legally recognized dimension of the workplace that is assumed to be a measurable concept, as an organizational level characteristic, that can be measured by individual perceptions and experiences with the social climate. One purpose of this study is the application and examination of a survey research approach, using a questionnaire composed of a combination of tested and untested items, in a university setting to determine an overall campus climate measure. A subsequent purpose is to analyze the campus climate survey instrument and the scales comprising the instrument to clarify and specify item validity and reliability measurement questions. While individual performance, associated with a higher education institution, may be attributed to many factors, it is felt that social climate becomes a key contextual concept influencing individual outcomes. Traditional variables [gender, age, social class, ethnicity, and sexual orientation] have been found to influence individual performance; however it is believed that social climate is a significant intervening variable modifying or distorting individual performance. Introducing and examining the effects of social climate will elucidate prior research linking traditional survey research variables with outcomes. In order to explicate these relationships in a higher education social system, a campus climate scale must be constructed responding to various measurement questions and issues

JWST/NIRCam Coronagraphy of the Young Planet-hosting Debris Disk AU Microscopii

High-contrast imaging of debris disk systems permits us to assess the composition and size distribution of circumstellar dust, to probe recent dynamical histories, and to directly detect and characterize embedded exoplanets. Observations of these systems in the infrared beyond 2--3 $\mu$m promise access to both extremely favorable planet contrasts and numerous scattered-light spectral features -- but have typically been inhibited by the brightness of the sky at these wavelengths. We present coronagraphy of the AU Microscopii (AU Mic) system using JWST's Near Infrared Camera (NIRCam) in two filters spanning 3--5 $\mu$m. These data provide the first images of the system's famous debris disk at these wavelengths and permit additional constraints on its properties and morphology. Conducting a deep search for companions in these data, we do not identify any compelling candidates. However, with sensitivity sufficient to recover planets as small as $\sim 0.1$ Jupiter masses beyond $\sim 2^{\prime\prime}$ ($\sim 20$ au) with $5\sigma$ confidence, these data place significant constraints on any massive companions that might still remain at large separations and provide additional context for the compact, multi-planet system orbiting very close-in. The observations presented here highlight NIRCam's unique capabilities for probing similar disks in this largely unexplored wavelength range, and provide the deepest direct imaging constraints on wide-orbit giant planets in this very well studied benchmark system.Comment: 27 pages, 14 figure

Viral trans-factor independent replication of human papillomavirus genomes

<p>Abstract</p> <p>Background</p> <p>Papillomaviruses (PVs) establish a persistent infection in the proliferating basal cells of the epithelium. The viral genome is replicated and maintained as a low-copy nuclear plasmid in basal keratinocytes. Bovine and human papillomaviruses (BPV and HPV) are known to utilize two viral proteins; E1, a DNA helicase, and E2, a transcription factor, which have been considered essential for viral DNA replication. However, growing evidence suggests that E1 and E2 are not entirely essential for stable replication of HPV.</p> <p>Results</p> <p>Here we report that multiple HPV16 mutants, lacking either or both E1 and E2 open reading frame (ORFs) and the long control region (LCR), still support extrachromosomal replication. Our data clearly indicate that HPV16 has a mode of replication, independent of viral trans-factors, E1 and E2, which is achieved by origin activity located outside of the LCR.</p

Entry into force and then? The Paris agreement and state accountability

The entry into force of the Paris Agreement on climate change brings expectations that states will be held to account for their commitments. The article elaborates on why this is not a realistic assumption unless a broader multilevel perspective is taken on the nature of accountability regimes for international (legal) agreements. The formal accountability mechanisms of such agreements tend to be weak, and there are no indications that they will be stronger for the recent global goals adopted in the Paris Agreement. Looking beyond only peer review among states, national institutions, direct civil society engagement and internal government processes – while each coming with their own strengths and weaknesses – provide additional accountability pathways that together may do a better job. Scientific enquiry is, however, required to better understand, support and find improved mixtures of, and perhaps to move beyond, these accountability pathways. Policy relevance This perspective provides something of a clarion call for a variety of different types of actors at both global and national levels to engage in ensuring that states keep the promises they made in the Paris Agreement. It particularly highlights the importance of national institutions and civil society to step up to the task in the present world order, where states are reluctant to build strong accountability regimes at the global level