Program Design and Student Outcomes in Graduate Education

Doctoral programs in the humanities and related social sciences are characterized by high attrition and long time-to-degree. In response to these long-standing problems, the Andrew W. Mellon Foundation launched the Graduate Education Initiative (GEI) to improve the structure and organization of PhD programs, and in turn reduce attrition and shorten time-to-degree. Over a 10-year period starting in 1991, the Foundation provided a total of $80 million to 51 departments at 10 major research universities. This paper estimates the impact of the GEI on attrition rates and time-to-degree. Our analysis is based on a competing-risk duration model and student-level data spanning the start of the GEI, including data on students at a set of control departments. We estimate that, on average, the GEI had modest impacts on student outcomes in the expected directions: reducing attrition rates, reducing time-to-degree, and increasing completion rates. The overall impacts of the GEI appear to have been driven in part by reductions in cohort size, increases in financial aid, and increases in student quality

Gut microbiota, metabolism and psychopathology:A critical review and novel perspectives

Psychiatric disorders are often associated with metabolic comorbidities. However, the mechanisms through which metabolic and psychiatric disorders are connected remain unclear. Pre-clinical studies in rodents indicate that the bidirectional signaling between the intestine and the brain, the so-called microbiome-gut-brain axis, plays an important role in the regulation of both metabolism and behavior. The gut microbiome produces a vast number of metabolites that may be transported into the host and play a part in homeostatic control of metabolism as well as brain function. In addition to short chain fatty acids, many of these metabolites have been identified in recent years. To what extent both microbiota and their products control human metabolism and behavior is a subject of intense investigation. In this review, we will discuss the most recent findings concerning alterations in the gut microbiota as a possible pathophysiological factor for the co-occurrence of metabolic comorbidities in psychiatric disorders

The effect of three years of TNF alpha blocking therapy on markers of bone turnover and their predictive value for treatment discontinuation in patients with ankylosing spondylitis: a prospective longitudinal observational cohort study

INTRODUCTION: The aim of this study was to investigate the effect of three years of tumor necrosis factor-alpha (TNF-alpha) blocking therapy on bone turnover as well as to analyze the predictive value of early changes in bone turnover markers (BTM) for treatment discontinuation in patients with ankylosing spondylitis (AS). METHODS: This is a prospective cohort study of 111 consecutive AS outpatients who started TNF-alpha blocking therapy. Clinical assessments and BTM were assessed at baseline, three and six months, as well as at one, two, and three years. Z-scores of BTM were calculated to correct for age and gender. Bone mineral density (BMD) was assessed yearly. RESULTS: After three years, 72 patients (65%) were still using their first TNF-alpha blocking agent. In these patients, TNF-alpha blocking therapy resulted in significantly increased bone-specific alkaline phosphatase, a marker of bone formation; decreased serum collagen-telopeptide (sCTX), a marker of bone resorption; and increased lumbar spine and hip BMD compared to baseline. Baseline to three months decrease in sCTX Z-score (HR: 0.394, 95% CI: 0.263 to 0.591), AS disease activity score (ASDAS; HR: 0.488, 95% CI: 0.317 to 0.752), and physician's global disease activity (HR: 0.739, 95% CI: 0.600 to 0.909) were independent inversely related predictors of time to treatment discontinuation because of inefficacy or intolerance. Early decrease in sCTX Z-score correlated significantly with good long-term response regarding disease activity, physical function and quality of life. CONCLUSIONS: Three years of TNF-alpha blocking therapy results in a bone turnover balance that favors bone formation, especially mineralization, in combination with continuous improvement of lumbar spine BMD. Early change in sCTX can serve as an objective measure in the evaluation of TNF-alpha blocking therapy in AS, in addition to the currently used more subjective measures

Combinatie van varroabehandeling en raatvernieuwing

Waarom hij het ooit gelezen of gehoord heeft, hij kan het zich niet meer goed herinneren. Maar het betreft een methode om aan het eind van het seizoen alle oude raten van een volk te vervangen door kunstraat en vervolgens een Varroabehandeling toe te passen. Nu hoor je wel vaker bepaalde methodes om de varroamijt te bestrijden. En dan denk je “Het zal wel”. Dit is echter een methode die elke imker eenvoudig kan toepassen en die grote voordelen biedt. We laten Herman Groen aan het woord

Hospitality in a theatre: The role of physical warmth

Insight into psychological mechanisms offers service organisations the opportunity to increase their hospitality performance. The present research shows that physical warmth positively contributes to people’s experience of hospitality. In a field experiment among 127 visitors to a theatre, the effects of cold versus hot drinks and furniture on the experience of hospitality were examined using the Experience of Hospitality Scale (EH scale), measuring the three experiential factors of hospitality: inviting, care and comfort. In line with embodiment theory, hot drinks positively influenced the experience of the care factor of hospitality in the theatre foyer by triggering the abstract metaphor of mental warmth. However, warm furniture showed no effect, which supports the assumption that the effects of short- and long-term exposure to physical warmth are different. This study is the first to show a relationship between physically warm objects and the experience of hospitality in a service-oriented environment

Buckfastteeltgroep Marken

Nadat één van de oprichters van de Teeltgroep Marken bemerkte dat er voor veel collega imkrws een mysterieuze waas hangt om de teeltgroep, besloot hij om er in Bijenhouden een artikel aan te wijden. Dit artikel over de Buckfastteeltgroep Marke

Viewpoint: filovirus haemorrhagic fever outbreaks: much ado about nothing?

The recent outbreak of Marburg haemorrhagic fever in the Democratic Republic of Congo has put the filovirus threat back on the international health agenda. This paper gives an overview of Marburg and Ebola outbreaks so far observed and puts them in a public health perspective. Damage on the local level has been devastating at times, but was marginal on the international level despite the considerable media attention these outbreaks received. The potential hazard of outbreaks, however, after export of filovirus from its natural environment into metropolitan areas, is argued to be considerable. Some avenues for future research and intervention are explored. Beyond the obvious need to find the reservoir and study the natural history, public health strategies for a more timely and efficient response are urgently needed

Two-dimensional superconductivity at the (111)LaAlO3_3/SrTiO3_3 interface

We report on the discovery and transport study of the superconducting ground state present at the (111)LaAlO$_3$/SrTiO$_3$ interface. The superconducting transition is consistent with a Berezinskii-Kosterlitz-Thouless transition and its 2D nature is further corroborated by the anisotropy of the critical magnetic field, as calculated by Tinkham. The estimated superconducting layer thickness and coherence length are 10 nm and 60 nm, respectively. The results of this work provide a new platform to clarify the microscopic details of superconductivity at LaAlO$_3$/SrTiO$_3$ interfaces, in particular in what concerns the link with orbital symmetry.Comment: 4 pages, 4 figure