Technical Support for Geopressured Geothermal Well Activities in Louisiana Annual Report

The rationale previously developed and utilized in interpreting various databases were outlined in the DOE final report titled "Technical Support for Geopressured-Geothermal Well Activities in Louisiana" (August 31, 1981), authored by Fred M. Wrighton, Don G. Bebout, Dale R. Carver, Charles G. Groat, and Adrain E. Johnson, Jr., under Contract No. DE-AS05-78ET27160. Due to the importance of the concepts presented in the previous report for developing an assessment evaluation program, much of the text and illustrations have been repeated for the convenience of the reader. However, the assessment techniques and calculations presented in this report are new. Estimates of the in-place methane resource in the geopressured zone of the U.S. Gulf Coast have varied widely, ranging from less than 1000 trillion cubic feet (TCF) to 49,000 TCF. The most recent assessment for onshore Texas, conducted by Gregory, Dodge, Posey, and Morton in 1981, estimated a total of 690 TCF. Well logs from deep oil and gas wells served as the primary data source for all assessment studies, although the interpretation of these logs varied significantly. In this study focusing on Louisiana, the methods and results were found to compare favorably with those of Gregory and others for Texas. The assessment included the Wilcox, Frio, and Miocene formations. Constructing regional cross-sections across the south Louisiana Gulf Coast was a prime objective to aid in assessing the total solution-methane resource in place. These cross-sections provided point sources of information from key wells and offered insights into the significance of each well through logical correlations with others on the section. Additionally, detailed studies of smaller areas conducted at LSU and other institutions throughout the Gulf Coast were considered, with data from these studies also contributing to the assessment. The total area under consideration in south Louisiana exceeds 18,000 square miles, with geopressured formations including the Wilcox (1692 square miles), Frio (5200 square miles), and Miocene. Parameters considered in this assessment included pressure, sandstone volume, porosity, temperature, and salinity.Bureau of Economic Geolog

A holistic multi-methodology for sustainable renovation

A review of the barriers for building renovation has revealed a lack of methodologies, which can promote sustainability objectives and assist various stakeholders during the design stage of building renovation/retrofitting projects. The purpose of this paper is to develop a Holistic Multi-methodology for Sustainable Renovation, which aims to deal with complexity of renovation projects. It provides a framework through which to involve the different stakeholders in the design process to improve group learning and group decision-making, and hence make the building renovation design process more robust and efficient. Therefore, the paper discusses the essence of multifaceted barriers in building renovation regarding cultural changes and technological/physical changes. The outcome is a proposal for a multi-methodology framework, which is developed by introducing, evaluating and mixing methods from Soft Systems Methodologies (SSM) with Multiple Criteria Decision Making (MCDM). The potential of applying the proposed methodology in renovation projects is demonstrated through a case study

Neurogenic mechanisms in bladder and bowel ageing

The prevalence of both urinary and faecal incontinence, and also chronic constipation, increases with ageing and these conditions have a major impact on the quality of life of the elderly. Management of bladder and bowel dysfunction in the elderly is currently far from ideal and also carries a significant financial burden. Understanding how these changes occur is thus a major priority in biogerontology. The functions of the bladder and terminal bowel are regulated by complex neuronal networks. In particular neurons of the spinal cord and peripheral ganglia play a key role in regulating micturition and defaecation reflexes as well as promoting continence. In this review we discuss the evidence for ageing-induced neuronal dysfunction that might predispose to neurogenic forms of incontinence in the elderly

Extrinsic primary afferent signalling in the gut

Visceral sensory neurons activate reflex pathways that control gut function and also give rise to important sensations, such as fullness, bloating, nausea, discomfort, urgency and pain. Sensory neurons are organised into three distinct anatomical pathways to the central nervous system (vagal, thoracolumbar and lumbosacral). Although remarkable progress has been made in characterizing the roles of many ion channels, receptors and second messengers in visceral sensory neurons, the basic aim of understanding how many classes there are, and how they differ, has proven difficult to achieve. We suggest that just five structurally distinct types of sensory endings are present in the gut wall that account for essentially all of the primary afferent neurons in the three pathways. Each of these five major structural types of endings seems to show distinctive combinations of physiological responses. These types are: 'intraganglionic laminar' endings in myenteric ganglia; 'mucosal' endings located in the subepithelial layer; 'muscular–mucosal' afferents, with mechanosensitive endings close to the muscularis mucosae; 'intramuscular' endings, with endings within the smooth muscle layers; and 'vascular' afferents, with sensitive endings primarily on blood vessels. 'Silent' afferents might be a subset of inexcitable 'vascular' afferents, which can be switched on by inflammatory mediators. Extrinsic sensory neurons comprise an attractive focus for targeted therapeutic intervention in a range of gastrointestinal disorders.Australian National Health and Medical Research Counci

Sex Differences in the Brain: A Whole Body Perspective

Most writing on sexual differentiation of the mammalian brain (including our own) considers just two organs: the gonads and the brain. This perspective, which leaves out all other body parts, misleads us in several ways. First, there is accumulating evidence that all organs are sexually differentiated, and that sex differences in peripheral organs affect the brain. We demonstrate this by reviewing examples involving sex differences in muscles, adipose tissue, the liver, immune system, gut, kidneys, bladder, and placenta that affect the nervous system and behavior. The second consequence of ignoring other organs when considering neural sex differences is that we are likely to miss the fact that some brain sex differences develop to compensate for differences in the internal environment (i.e., because male and female brains operate in different bodies, sex differences are required to make output/function more similar in the two sexes). We also consider evidence that sex differences in sensory systems cause male and female brains to perceive different information about the world; the two sexes are also perceived by the world differently and therefore exposed to differences in experience via treatment by others. Although the topic of sex differences in the brain is often seen as much more emotionally charged than studies of sex differences in other organs, the dichotomy is largely false. By putting the brain firmly back in the body, sex differences in the brain are predictable and can be more completely understood