27 research outputs found
Effect of spring-back in v-tool bending of high-strength steel sheet metal plates
This paper deals with the effects of technological parameters used in the V-die bending process, on the obtained product properties and dimensions. By variation of the tool geometry, several cases of steel sheet bending process are observed through the FEM simulations. Also by variation of different mechanical material properties, effects on product geometry are observed. Since the automobile manufacturers mostly use the high strength steel sheet metal plates, there is a need for the successful tool construction and optimization in order to produce quality products
A common variant of the MACC1 gene is significantly associated with overall survival in colorectal cancer patients
<p>Abstract</p> <p>Background</p> <p>The newly discovered metastasis-associated in colon cancer-1 (MACC1) gene is a key regulator of the HGF/MET pathway. Deregulation of HGF/MET signaling is reported as a prognostic marker for tumorigenesis, early stage invasion, and metastasis. High expression levels of MACC1 have been associated with colon cancer metastasis and reduced survival. Potential links between the genetic diversity of the MACC1 locus and overall survival are unknown. We therefore investigated the association between MACC1 tagging single nucleotide polymorphisms (SNPs) and overall survival in a large cohort of colorectal cancer patients.</p> <p>Methods</p> <p>The study included 318 subjects with histopathologically proven colorectal cancer at the Academic Teaching Hospital Feldkirch, Austria. Survival data were provided by the federal agency for statistics in Austria. Genomic DNA was isolated from formalin-fixed paraffin-embedded specimens; six tagging SNPs (rs1990172, rs3114446, rs10275612, rs3095007, rs3095009, and rs7780032), capturing most of the common variants of the MACC1 locus, were genotyped by SNaPshot assays.</p> <p>Results</p> <p>Over a mean follow up period of 5.3 (± 1.0) years, 94 deaths were recorded. Carriers of the G-allele of SNP rs1990172 showed a significantly decreased overall survival (additive HR = 1.38 [1.05-1.82]; <it>p </it>= 0.023). Multivariate analysis adjusted for age and UICC tumor stage confirmed this result (HR = 1.49 [1.12-1.98]; <it>p </it>= 0.007). Other investigated genetic variants of the MACC1 gene were not significantly associated with overall survival (<it>p</it>-values > 0.05).</p> <p>Conclusions</p> <p>For the first time, our study investigated the influence of MACC1 tagging polymorphisms on overall survival suggesting SNP rs1990172 as a predictor for reduced overall survival in colorectal cancer patients. Further studies will be required to validate our findings.</p
Preliminary results of surgical equine embryo transfer after open pulled straw vitrification
International audienc
Protest
Holzer B. Protest. In: Jahraus O, Nassehi A, Grizelj M, Saake S, Kirchmeier C, Müller J, eds. Luhmann‐Handbuch. Leben – Werk – Wirkung. Stuttgart/Weimar: J.B. Metzler; 2012: 193-196
Influence of continuous breeding goats on return to cyclicity in seasonal breeding goats
The boer goats which originated from the South African
Republic are continous breeding animals when kept in the
northern hemisphere and they kidd three times in 2 years. In this
study, a mixed herd was monitored to determine whether boer
goats could induce return to cyclicity in sesonal breeding goats.
All goats (n = 20) were pluriparous and kidded during January
and February. During January a mixed group was formed (10
boer goats kept together with 10 domestic breed goats). At the
same time a group of domestic breed goats (n = 12), kept in the
same manner, 40 km away from the experimental group was
used as controls. Blood samples were collected every 72 h to
determine level of progesterone in both herds. Goats were
monitored at the same time to observe for signs of oestrus.
Progesterone concentrations in sera samples were determined
using a RIA method. Data were analysed by ANOVA using
Statistica software. We observed visual oestrus in all boer goats
and in eight domestic breed goats from the mixed group during
March and April. Progesterone concentrations confirmed the
presence of functional corpora lutea between two visual cycles in
these animals. No visual oestrus or increases in progesterone
were observed in the control group of goats. In conclusion,
continuous breeding boer goats induced oestrus in 80% (n = 8)
of seasonal breeding goats when kept in a mixed herd