Male osteoporosis: diagnosis and fracture risk evaluation

Male osteoporosis is challenging to diagnose and to treat. Underestimation of the risk of male osteoporosis, the combined presence of several interwoven causative factors in many patients, and uncertainty regarding the absorptiometry cutoffs associated with fractures are major obstacles to the diagnosis of male osteoporosis and to the identification of men at risk for fractures. The lifetime risk of osteoporotic fracture is estimated at 15% among men older than 50 years. One-third of proximal femoral fractures occur in men, and the associated mortality rate is 2- to 3-fold that in women. In men, nearly half the cases of osteoporosis are related to disease, medications, or risk factors. Although the criteria for diagnosing male osteoporosis are not agreed on, the definitions developed by the World Health Organization can be used provided the reference population is composed of young males. An absorptiometry T-score < or = -2.5 is useful for diagnosing osteoporosis but fails to adequately predict the fracture risk. The identification of men at high risk for fractures requires a combined evaluation of bone mineral density data, clinical risk factors, and risk factors for falls

MaDCrow, a Citizen Science Infrastructure to Monitor Water Quality in the Gulf of Trieste (North Adriatic Sea)

Within the United Nations Sustainable Development 2030 agenda, sustainable growth in the marine and maritime sector needs sea water quality monitoring. This is a very demanding and expensive task which results in the sea being largely undersampled. MaDCrow is a research and development project supported by the European Regional Development Fund, that involves citizens as data collectors while aiming to improve public environmental awareness and participation in scientific research. Its goal is to create an innovative technological infrastructure for real-time acquisition, integration and access of data, thus generating knowledge on sea water quality and marine ecosystem of the Gulf of Trieste. Data acquisition is based on an autonomous and removable device, developed within the project, that can be deployed on any small size sailing boat, recreational vessel, or fishing boat. The device holds low-cost sensors to measure pH, temperature, dissolved oxygen and salinity and the hardware and software to acquire, georeference and transmit the environmental data without interfering with the activities of the boats. In this work we analyze the use, capabilities and advantages of low-cost sensors but also their limitations, comparing, with a special focus on pH, their performances with those of the traditional ones. Applying the paradigm in a highly anthropized area such as the Gulf of Trieste, which is characterized also by a very high spatial and temporal variability of environments, we point out that this new approach allows to monitor sea water quality and highlight local anomalies with a resolution and spatial and temporal coverage that was not achievable with previous procedures, but yet at very low costs. Once received, data are then processed and submitted to a mediation flow that contextualizes and disseminates them for public use on a website. The final products have been customized to reach stakeholders such as tourists, fishermen and policy makers. The availability of information understandable to everyone, while fostering environmental awareness, stimulates, at the same time, involvement and participation of citizen scientists in the initiative. In the future, while committing to enlarge the number of participants, we will extend the analysis also toward other types of sensors

Chlamydia trachomatis infection among sexually active young women in Italy

Methods: In our study 3314 sexually active women between the ages of 14 and 25 were screened for C trachomatis by ligase chain reaction (LCR) using cervical swabs during the period 1997–2000 at the Turin School of Medicine. All the patients answered a specific questionnaire. Results: In our analysis the prevalence of C trachomatis infection was found to be 3.5%, and the average age among the infected patients was 22.12 years. Statistical analysis was performed using the χ(2) test. A p value <0.05 was considered significant. A correlation was found between a positive result and: membership of east European and central northern Africa populations (p<0.001), low levels of education (p<0.001), age at the first intercourse (p=0.006), the presence of symptoms in the women (p<0.001), and the number of sexual partners in the preceding 6 months (p<0.001). No statistically significant difference was found among the contraceptive methods used whether hormonal or a barrier type and with the subjective symptoms of the partner. Conclusion: Frequent microbiological examinations are desirable for patients whose anamnesis shows an increased risk of contracting sexually transmitted infections in order to avoid long term complications from misdiagnosed or asymptomatic pathologies; this often happens with C trachomatis infection

Perfil epidemiológico de mulheres com vaginose bacteriana, atendidas em um ambulatório de doenças sexualmente transmissíveis, em São Paulo, SP Epidemiological profile of women with bacterial vaginosis treated at a clinic for sexually transmitted diseases in the city of Sao Paulo, SP

FUNDAMENTOS - A vaginose bacteriana é doença de grande relevância devido à sua alta prevalência e suas complicações obstétricas e ginecológicas. OBJETIVO - Descrever o perfil epidemiológico das pacientes com diagnóstico de vaginose bacteriana, atendidas em um ambulatório de São Paulo, segundo variáveis de interesse social, demográfico e clínico. MÉTODOS - Estudo transversal descritivo, baseado nos prontuários de 658 mulheres atendidas de janeiro de 1999 a dezembro de 2004. Foram coletadas as seguintes informações: idade, cor, estado civil, procedência, grau de escolaridade, preferência sexual, número de parceiros e presença de doença sexualmente transmissível associada. RESULTADOS - A prevalência encontrada foi de 29%. Com relação ao perfil da mulher com vaginose bacteriana, observou-se maior ocorrência em jovens entre 10 e 19 anos (40%), negras (37,1%), viúvas (62,5%), com segundo grau incompleto (39,5%), heterossexuais (29,5%), com dois ou mais parceiros sexuais nos últimos 30 dias (50%) e nos últimos cinco anos (32,3%). A associação com outras doenças sexualmente transmissíveis, concomitante, foi encontrada em 31,9% dos casos. CONCLUSÃO - A distribuição dos casos segundo faixa etária, raça, número de parceiros sexuais e associação com outras doenças encontradas nas pacientes com diagnóstico de vaginose bacteriana foi semelhante aos dados encontrados na literatura. A ocorrência está dentro dos limites descritos (10 e 36%).<br>BACKGROUND- Bacterial vaginosis is an important disease on account of its high prevalence as well as the obstetrical and gynecological complications. OBJECTIVE- To present an epidemiological profile of patients diagnosed with bacterial vaginosis seen at an outpatient clinic in the city of Sao Paulo, Brazil, described according to socio-demographic and clinical variables. METHODS- A cross-sectional descriptive study was performed by collecting data from the medical records of 658 females, seen from January, 1999 to December, 2004. Our study took into account age, ethnicity, marital status, schooling, sexual preference, number of partners and associated sexual diseases. RESULTS- The prevalence observed was 29%. Regarding the profile of women with bacterial vaginosis, the highest ratio of cases occurred in adolescents aged 10 to 19 years old (40%), black women (37.1%), widows (62.5%), women who have not graduated from high school (39.5%), heterosexual women (29.5%), women with two or more sexual partners in the last 30 days (50%) and in the last five years (35.3%). The concomitant association with other sexually transmitted diseases was found in 35% of cases. CONCLUSION- The distribution of bacterial vaginosis in patients according to age, ethnicity, number of sexual partners and associated sexual diseases was similar to that described in the literature. The observed ratio was within values of other studies (10 to 36%)

Genetics of innate immunity and UTI susceptibility.

A functional and well-balanced immune response is required to resist most infections. Slight dysfunctions in innate immunity can turn the 'friendly' host defense into an unpleasant foe and give rise to disease. Beneficial and destructive forces of innate immunity have been discovered in the urinary tract and mechanisms by which they influence the severity of urinary tract infections (UTIs) have been elucidated. By modifying specific aspects of the innate immune response to UTI, genetic variation either exaggerates the severity of acute pyelonephritis to include urosepsis and renal scarring or protects against symptomatic disease by suppressing innate immune signaling, as in asymptomatic bacteriuria (ABU). Different genes are polymorphic in patients prone to acute pyelonephritis or ABU, respectively, and yet discussions of UTI susceptibility in clinical practice still focus mainly on social and behavioral factors or dysfunctional voiding. Is it not time for UTIs to enter the era of molecular medicine? Defining why certain individuals are protected from UTI while others have severe, recurrent infections has long been difficult, but progress is now being made, encouraging new approaches to risk assessment and therapy in this large and important patient group, as well as revealing promising facets of 'good' versus 'bad' inflammation