372 research outputs found
Intensity modulated radiation therapy for squamous cell carcinoma of the vulva: Treatment technique and outcomes
Effect of Supplementation on Performance and Faecal Particle Size Distribution for Yearling Horses and Weaned Calves Grazing Coastal Bermudagrass
Supplements are often fed, especially to horses, without realistic expectations of the magnitude of performance response nor knowledge of biological or economic efficiencies of supplementation. The objectives of this experiment were to compare performance of weaned calves vs yearling horses grazing \u27Coastal\u27 bermudagrass [Cynodon dactylon (L.) Pers] (COS) pastures with and without a protein-energy supplement, and to assess faecal particle size distribution for both calves and horses to document digesta dynamics
Clinical implementation of multisequence MRI-based adaptive intracavitary brachytherapy for cervix cancer
Drivers of spatial change in urban housing submarkets
Spatial urban housing submarkets are now widely used constructs. Recent housing market modelling strategies have emphasised the need for flexibility in modelling approaches in order to best accommodate submarkets which account for spatial variations in hedonic prices. But this raises important unanswered questions concerning the stability of submarket structures over time, and the role of housing market dynamics in breaking down or shifting submarket boundaries. The influence of new supply, in particular, may have a stabilising or destabilising effect on differences in hedonic prices, depending on the wider housing market context. In this paper we examine the temporal influence of new supply, intra‐urban migration and socio‐economic change as a means of understanding the impact of key drivers of submarket boundary change. Using the Greater Perth region of Western Australia as a case study, we estimate income elasticities of demand for housing services that vary spatially within the urban area. We find evidence that higher income elasticities, new development, socio‐economic change and intra‐urban migration are associated with changes in the spatial structure of housing prices within the metropolitan housing market
Discovery of the first tau Sco analogues: HD 66665 and HD 63425
The B0.2 V magnetic star tau Sco stands out from the larger population of
massive OB stars due to its high X-ray activity, peculiar wind diagnostics and
highly complex magnetic field. This paper presents the discovery of the first
two tau Sco analogues - HD 66665 and HD 63425, identified by the striking
similarity of their UV spectra to that of tau Sco. ESPaDOnS spectropolarimetric
observations were secured by the Magnetism in Massive Stars CFHT Large Program,
in order to characterize the stellar and magnetic properties of these stars.
CMFGEN modelling of optical ESPaDOnS spectra and archived IUE UV spectra showed
that these stars have stellar parameters similar to those of tau Sco. A
magnetic field of similar surface strength is found on both stars, reinforcing
the connection between the presence of a magnetic field and wind peculiarities.
However, additional phase-resolved observations will be required in order to
assess the potential complexity of the magnetic fields, and verify if the wind
anomalies are linked to this property.Comment: 6 pages, 2 tables, 3 figures. Accepted for publication in MNRAS. The
definitive version will be available at www.blackwel-synergy.co
Competing Ideas of Social Justice and Space: Locating Critiques of Housing Renewal in Theory and in Practice
This article considers the experience of the English government's policy of Housing Market Renewal from the perspective of spatial justice. The paper first proposes an analytical framework that situates competing notions of territorial social justice within a space of complex sociospatial relations. The dialectic of two formulations of social justice is first set up, comparing 'procedural' or deontological forms of justice and the distributional justice of outcomes. Soja's formulation of spatial justice is advanced as an appropriate balance between spatial and socio-historic contexts for the justice question. Drawing on the literature on sociospatial relations, concrete critiques and justifications of HMR are then positioned in terms of the intersection of structuring principles and policy fields. The role of demolition in urban restructuring programmes is used to explore the differential spatialities involved in different justicial perspectives. It is concluded that 'gentrification' critiques of HMR are only partial in their evaluation of justice and lack normative power. Some practical implications for the design of urban restructuring policies are offered
Notch-Deficient Skin Induces a Lethal Systemic B-Lymphoproliferative Disorder by Secreting TSLP, a Sentinel for Epidermal Integrity
Epidermal keratinocytes form a highly organized stratified epithelium and sustain a competent barrier function together with dermal and hematopoietic cells. The Notch signaling pathway is a critical regulator of epidermal integrity. Here, we show that keratinocyte-specific deletion of total Notch signaling triggered a severe systemic B-lymphoproliferative disorder, causing death. RBP-j is the DNA binding partner of Notch, but both RBP-j–dependent and independent Notch signaling were necessary for proper epidermal differentiation and lipid deposition. Loss of both pathways caused a persistent defect in skin differentiation/barrier formation. In response, high levels of thymic stromal lymphopoietin (TSLP) were released into systemic circulation by Notch-deficient keratinocytes that failed to differentiate, starting in utero. Exposure to high TSLP levels during neonatal hematopoiesis resulted in drastic expansion of peripheral pre- and immature B-lymphocytes, causing B-lymphoproliferative disorder associated with major organ infiltration and subsequent death, a previously unappreciated systemic effect of TSLP. These observations demonstrate that local skin perturbations can drive a lethal systemic disease and have important implications for a wide range of humoral and autoimmune diseases with skin manifestations
The decline and rise of neighbourhoods: the importance of neighbourhood governance
There is a substantial literature on the explanation of neighbourhood change. Most of this literature concentrates on identifying factors and developments behind processes of decline. This paper reviews the literature, focusing on the identification of patterns of neighbourhood change, and argues that the concept of neighbourhood governance is a missing link in attempts to explain these patterns. Including neighbourhood governance in the explanations of neighbourhood change and decline will produce better explanatory models and, finally, a better view about what is actually steering neighbourhood change
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Preliminary Safety Criteria for Organic Watch List Tanks at the Hanford Site
Condensed-phase, rapid reactions of organic salts with nitrates/nitrites in Hanford High Level Radioactive Waste single-shell tanks could lead to structural failure of the tanks resulting in significant releases of radionuclides and toxic materials. This report establishes appropriate preliminary safety criteria to ensure that tank wastes will be maintained safe. These criteria show that if actual dry wastes contain less than 1.2 MJ/kg of reactants reaction energy or less 4.5 wt % of total organic carbon, then the waste will be safe and will not propagate if ignited. Waste moisture helps to retard reactions; when waste moisture exceeds 20 wt %, rapid reactions are prevented, regardless of organic carbon concentrations. Aging and degradation of waste materials has been considered to predict the types and amounts to organic compounds present in the waste. Using measurements of 3 waste phases (liquid, salt cake, and sludge) obtained from tank waste samples analyzed in the laboratory, analysis of variance (ANOVA) models were used to estimate waste states for unmeasured tanks. The preliminary safety criteria are based upon calorimetry and propagation testing of likely organic compounds which represent actual tank wastes. These included sodium salts of citrate, formate, acetate and hydroxyethylethylenediaminetricetate (HEDTA). Hot cell tests of actual tank wastes are planned for the future to confirm propagation tests performed in the laboratory. The effects of draining liquids from the tanks which would remove liquids and moisture were considered because reactive waste which is too dry may propagate. Evaporation effects which could remove moisture from the tanks were also calculated. The various ways that the waste could be heated or ignited by equipment failures or tank operations activities were considered and appropriate monitoring and controls were recommended
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