2,638 research outputs found
A geometric method for model reduction of biochemical networks with polynomial rate functions
The temperature dependence of the isothermal bulk modulus at 1 bar pressure
It is well established that the product of the volume coefficient of thermal
expansion and the bulk modulus is nearly constant at temperatures higher than
the Debye temperature. Using this approximation allows predicting the values of
the bulk modulus. The derived analytical solution for the temperature
dependence of the isothermal bulk modulus has been applied to ten substances.
The good correlations to the experiments indicate that the expression may be
useful for substances for which bulk modulus data are lacking
Multi-rendezvous Spacecraft Trajectory Optimization with Beam P-ACO
The design of spacecraft trajectories for missions visiting multiple
celestial bodies is here framed as a multi-objective bilevel optimization
problem. A comparative study is performed to assess the performance of
different Beam Search algorithms at tackling the combinatorial problem of
finding the ideal sequence of bodies. Special focus is placed on the
development of a new hybridization between Beam Search and the Population-based
Ant Colony Optimization algorithm. An experimental evaluation shows all
algorithms achieving exceptional performance on a hard benchmark problem. It is
found that a properly tuned deterministic Beam Search always outperforms the
remaining variants. Beam P-ACO, however, demonstrates lower parameter
sensitivity, while offering superior worst-case performance. Being an anytime
algorithm, it is then found to be the preferable choice for certain practical
applications.Comment: Code available at https://github.com/lfsimoes/beam_paco__gtoc
Integrative Modeling of Electrical Properties of Pacemaker Cardiac Cells
This work represents modeling of electrical properties of pacemaker (sinus) cardiac cells. Special attention is paid to electrical potential arising from transmembrane current of Na{+}, K{+} and Ca{2+} ions. This potential is calculated using the NaCaX model. In this respect, molar concentration of ions in the intercellular space which is calculated on the basis of the GENTEX model is essential. Combined use of two different models allows referring this approach to integrative modeling
Dynamical mechanism of atrial fibrillation: a topological approach
While spiral wave breakup has been implicated in the emergence of atrial
fibrillation, its role in maintaining this complex type of cardiac arrhythmia
is less clear. We used the Karma model of cardiac excitation to investigate the
dynamical mechanisms that sustain atrial fibrillation once it has been
established. The results of our numerical study show that spatiotemporally
chaotic dynamics in this regime can be described as a dynamical equilibrium
between topologically distinct types of transitions that increase or decrease
the number of wavelets, in general agreement with the multiple wavelets
hypothesis. Surprisingly, we found that the process of continuous excitation
waves breaking up into discontinuous pieces plays no role whatsoever in
maintaining spatiotemporal complexity. Instead this complexity is maintained as
a dynamical balance between wave coalescence -- a unique, previously
unidentified, topological process that increases the number of wavelets -- and
wave collapse -- a different topological process that decreases their number.Comment: 15 pages, 14 figure
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