161 research outputs found
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The role of temperature in the variability and extremes of electricity and gas demand in Great Britain
The daily relationship of electricity and gas demand with temperature in Great Britain is analysed from 1975 to 2013 and 1996 to 2013 respectively. The annual mean and annual cycle amplitude of electricity demand exhibit low frequency variability. This low frequency variability is thought to be predominantly driven by socio-economic changes rather than temperature variation. Once this variability is removed, both daily electricity and gas demand have a strong anti-correlation with temperature (r elec = ā0.90 , r gas = ā0.94). However these correlations are inflated by the changing demandātemperature relationship during spring and autumn. Once the annual cycles of temperature and demand are removed, the correlations are and . Winter then has the strongest demandātemperature relationship, during which a 1 Ā°C reduction in daily temperature typically gives a ~1% increase in daily electricity demand and a 3%ā4% increase in gas demand. Extreme demand periods are assessed using detrended daily temperature observations from 1772. The 1 in 20 year peak day electricity and gas demand estimates are, respectively, 15% (range 14%ā16%) and 46% (range 44%ā49%) above their average winter day demand during the last decade. The risk of demand exceeding recent extreme events, such as during the winter of 2009/2010, is also quantified
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The changing sensitivity of power systems to meteorological drivers: a case study of Great Britain
The increasing use of intermittent renewable generation (such as wind) is increasing the exposure of national power systems to meteorological variability. This study identifies how the integration of wind power in one particular country (Great Britain, GB) is affecting the overall sensitivity of the power system to weather using three key metrics: total annual energy requirement and peak residual load (from sources other than wind) and wind power curtailment.
The present-day level of wind power capacity (approximately 15GW) is shown to have already changed the power system's overall sensitivity to weather in terms of the total annual energy requirement, from a temperature- to a wind-dominated regime (which occurred with 6GW of installed wind power capacity). Peak residual load from sources other than wind also shows a similar shift. The associated changes in the synoptic- and large-scale meteorological drivers associated with each metric are identified and discussed. In a period where power systems are changing rapidly, it is therefore argued that past experience of the weather impacts on the GB power system may not be a good guide for the impact on the present or near-future power system
Mutations in SPG11, encoding spatacsin, are a major cause of spastic paraplegia with thin corpus callosum.
Autosomal recessive hereditary spastic paraplegia (ARHSP) with thin corpus
callosum (TCC) is a common and clinically distinct form of familial spastic
paraplegia that is linked to the SPG11 locus on chromosome 15 in most affected
families. We analyzed 12 ARHSP-TCC families, refined the SPG11 candidate interval
and identified ten mutations in a previously unidentified gene expressed
ubiquitously in the nervous system but most prominently in the cerebellum,
cerebral cortex, hippocampus and pineal gland. The mutations were either nonsense
or insertions and deletions leading to a frameshift, suggesting a
loss-of-function mechanism. The identification of the function of the gene will
provide insight into the mechanisms leading to the degeneration of the
corticospinal tract and other brain structures in this frequent form of ARHSP
Pylons in the back yard: local planning and perceived risks to health
Health fears arising from the presence of high-voltage power lines in residential areas have received recent attention in spatial planning. A study of stances taken by planning authorities in England and Wales shows their willingness to give expression to the concerns of local communities through precautionary measures, and the difficulties encountered in the face of official statements and industry opposition. These attempts to embody local feeling in patterns of development are illustrative of the increasing prevalence of a sense of risk in contemporary society. The spatial patterns of risk are also revealed, which owe much to the presence and distribution of industrial infrastructure in the landscape and to the associated contested use of land.</p
ScotGrid: Providing an Effective Distributed Tier-2 in the LHC Era
ScotGrid is a distributed Tier-2 centre in the UK with sites in Durham,
Edinburgh and Glasgow. ScotGrid has undergone a huge expansion in hardware in
anticipation of the LHC and now provides more than 4MSI2K and 500TB to the LHC
VOs. Scaling up to this level of provision has brought many challenges to the
Tier-2 and we show in this paper how we have adopted new methods of organising
the centres, from fabric management and monitoring to remote management of
sites to management and operational procedures, to meet these challenges. We
describe how we have coped with different operational models at the sites,
where Glagsow and Durham sites are managed "in house" but resources at
Edinburgh are managed as a central university resource. This required the
adoption of a different fabric management model at Edinburgh and a special
engagement with the cluster managers. Challenges arose from the different job
models of local and grid submission that required special attention to resolve.
We show how ScotGrid has successfully provided an infrastructure for ATLAS and
LHCb Monte Carlo production. Special attention has been paid to ensuring that
user analysis functions efficiently, which has required optimisation of local
storage and networking to cope with the demands of user analysis. Finally,
although these Tier-2 resources are pledged to the whole VO, we have
established close links with our local physics user communities as being the
best way to ensure that the Tier-2 functions effectively as a part of the LHC
grid computing framework..Comment: Preprint for 17th International Conference on Computing in High
Energy and Nuclear Physics, 7 pages, 1 figur
CMS distributed computing workflow experience
The vast majority of the CMS Computing capacity, which is organized in a tiered hierarchy, is located away from CERN. The 7 Tier-1 sites archive the LHC proton-proton collision data that is initially processed at CERN. These sites provide access to all recorded and simulated data for the Tier-2 sites, via wide-area network (WAN) transfers. All central data processing workflows are executed at the Tier-1 level, which contain re-reconstruction and skimming workflows of collision data as well as reprocessing of simulated data to adapt to changing detector conditions. This paper describes the operation of the CMS processing infrastructure at the Tier-1 level. The Tier-1 workflows are described in detail. The operational optimization of resource usage is described. In particular, the variation of different workflows during the data taking period of 2010, their efficiencies and latencies as well as their impact on the delivery of physics results is discussed and lessons are drawn from this experience. The simulation of proton-proton collisions for the CMS experiment is primarily carried out at the second tier of the CMS computing infrastructure. Half of the Tier-2 sites of CMS are reserved for central Monte Carlo (MC) production while the other half is available for user analysis. This paper summarizes the large throughput of the MC production operation during the data taking period of 2010 and discusses the latencies and efficiencies of the various types of MC production workflows. We present the operational procedures to optimize the usage of available resources and we the operational model of CMS for including opportunistic resources, such as the larger Tier-3 sites, into the central production operation
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Quantifying the increasing sensitivity of power systems to climate variability
Large quantities of weather-dependent renewable energy generation are expected in power systems under climate change mitigation policies, yet little attention has been given to the impact of long term climate variability. By combining state-ofthe-art multi-decadal meteorological records with a parsimonious representation of a power system, this study characterises the impact of year-to-year climate variability on multiple aspects of the power system of Great Britain (including coal, gas and
nuclear generation), demonstrating why multi-decadal approaches are necessary. All aspects of the example system are impacted by inter-annual climate variability, with the impacts being most pronounced for baseload generation. The impacts of inter-annual climate variability increase in a 2025 wind-power scenario, with a 4-fold increase in
the inter-annual range of operating hours for baseload such as nuclear. The impacts on peak load and peaking-plant are comparably small. Less than 10 years of power supply and demand data are shown to be insuffcient for providing robust power system planning guidance. This suggests renewable integration studies - widely used in policy, investment and system design - should adopt a more robust approach to climate characterisation
āI h 8 uā: Findings from a five-year study of text and e-mail bullying
Copyright @ 2010 British Educational Research Association. The final version of this article is available at the link below.This study charts reports of nasty or threatening text and e-mail messages received by students in academic years 7 and 8 (11-13 years of age) attending 13 secondary schools in the North of England between 2002-2006. Annual surveys were undertaken on behalf of the local education authority (LEA) to monitor bullying. Results indicated that, over five years, the number of pupils receiving one or more nasty or threatening text messages or e-mails increased significantly, particularly among girls. However, receipt of frequent nasty or threatening text and e-mail messages remained relatively stable. For boys, being a victim of direct-physical bullying was associated with receiving nasty or threatening text and e-mail messages; for girls it was being unpopular among peers. Boys received more hate-related messages and girls were primarily the victims of name-calling, Findings are discussed with respect to theoretical and policy developments, and recommendations for future research are offered
The International Collaboration for Research methods Development in Oncology (CReDO) workshops: shaping the future of global oncology research
Low-income and middle-income countries (LMICs) have a disproportionately high burden of cancer and cancer mortality. The unique barriers to optimum cancer care in these regions necessitate context-specific research. The conduct of research in LMICs has several challenges, not least of which is a paucity of formal training in research methods. Building capacity by training early career researchers is essential to improve research output and cancer outcomes in LMICs. The International Collaboration for Research methods Development in Oncology (CReDO) workshop is an initiative by the Tata Memorial Centre and the National Cancer Grid of India to address gaps in research training and increase capacity in oncology research. Since 2015, there have been five CReDO workshops, which have trained more than 250 oncologists from India and other countries in clinical research methods and protocol development. Participants from all oncology and allied fields were represented at these workshops. Protocols developed included clinical trials, comparative effectiveness studies, health services research, and observational studies, and many of these protocols were particularly relevant to cancer management in LMICs. A follow-up of these participants in 2020 elicited an 88% response rate and showed that 42% of participants had made progress with their CReDO protocols, and 73% had initiated other research protocols and published papers. In this Policy Review, we describe the challenges to research in LMICs, as well as the evolution, structure, and impact of CReDO and other similar workshops on global oncology research
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