Enabling policy environment for water, food and energy security

The complexity of water, food and energy security is analysed from the perspectives of (i) water and food and (ii) water and energy and their interconnectivity and focuses ultimately on water as a primary input into processes, the entry point for participants of the Third World Irrigation Forum. The paper provides an overview of trends in water, food and energy security, highlights the interconnectivity between the various elements and introduces the water–food–energy nexus as a tool for improving productivity and sector policies, avoiding unintended consequences on other sectors. Invariably, there will be trade‐offs and the challenge is to find combinations of measures that have a net positive outcome. In order to quantify security in the three elements and the trade‐offs between them, emerging modelling approaches for the nexus are discussed. Sub‐theme 3 of the forum focuses on productivity and technology interventions and sub‐theme 2 on stakeholder interaction. The combination of modelling, technology innovations and stakeholder participation in a water–food–energy nexus approach leads to better understanding of linkages and more robust policies and is used to derive recommendations for an enabling policy environment

Desmoglein-2 is important for islet function and β-cell survival

Type 1 diabetes is a complex disease characterized by the lack of endogenous insulin secreted from the pancreatic β-cells. Although β-cell targeted autoimmune processes and β-cell dysfunction are known to occur in type 1 diabetes, a complete understanding of the cell-to-cell interactions that support pancreatic function is still lacking. To characterize the pancreatic endocrine compartment, we studied pancreata from healthy adult donors and investigated a single cell surface adhesion molecule, desmoglein-2 (DSG2). Genetically-modified mice lacking Dsg2 were examined for islet cell mass, insulin production, responses to glucose, susceptibility to a streptozotocin-induced mouse model of hyperglycaemia, and ability to cure diabetes in a syngeneic transplantation model. Herein, we have identified DSG2 as a previously unrecognized adhesion molecule that supports β-cells. Furthermore, we reveal that DSG2 is within the top 10 percent of all genes expressed by human pancreatic islets and is expressed by the insulin-producing β-cells but not the somatostatin-producing δ-cells. In a Dsg2 loss-of-function mice (Dsg2lo/lo), we observed a significant reduction in the number of pancreatic islets and islet size, and consequently, there was less total insulin content per islet cluster. Dsg2lo/lo mice also exhibited a reduction in blood vessel barrier integrity, an increased incidence of streptozotocininduced diabetes, and islets isolated from Dsg2lo/lo mice were more susceptible to cytokine-induced β-cell apoptosis. Following transplantation into diabetic mice, islets isolated from Dsg2lo/lo mice were less effective than their wildtype counterparts at curing diabetes. In vitro assays using the Beta-TC-6 murine β-cell line suggest that DSG2 supports the actin cytoskeleton as well as the release of cytokines and chemokines. Taken together, our study suggests that DSG2 is an under-appreciated regulator of β-cell function in pancreatic islets and that a better understanding of this adhesion molecule may provide new opportunities to combat type 1 diabetes.Kay K. Myo Min, Darling Rojas-Canales, Daniella Penko, Mark DeNichilo, Michaelia P. Cockshell, Charlie B. Ffrench, Emma J. Thompson, Olof Asplund, Christopher J. Drogemuller, Rashmi B. Prasad, Leif Groop, Shane T. Grey, Helen E. Thomas, Thomas Loudovaris, Thomas W. Kay, My G. Mahoney, Claire F. Jessup, P. Toby Coates, and Claudine S. Bonde

The Ediacaran Aspidella-type impressions in the Jinxian successions of Liaoning Province, northeastern China

We identify the macroscopic impression fossils from the Xingmincun Formation of the Jinxian Group, Liaoning Province of northeastern China as members of the Aspidella plexus of the Ediacaran age. This is the first recognition of the taxon in the Liaoning Province, although such fossils have been previously recorded in the succession but were referred to as new species and relegated to an earlier Neoproterozoic age. A revision of the taxonomic interpretation and relative age estimation of the previous record is provided as well as an evaluation of abiotic vs biotic processes that could produce similar structures to studied impressions. We consider the mode of preservation of the fossils from a biochemical point of view and the properties of organic matter in the integument of soft-bodied metazoans. The selective preservation of the Ediacaran organisms, including metazoans, as impressions (moulds and casts) against the organically preserved contemporaneous cyanobacterial and algal microfossils and an exceptionally small number of terminal Ediacaran metazoan fossils (Sabellidites, Conotubus and Shaanxilites), demonstrates the non-resistant characteristics and the very different biochemical constitution of the Ediacaran metazoans compared with those that evolved in the Cambrian and after. The refractory biomacromolecules in cell walls of photosynthesizing microbiota (bacterans, cutans, algaenan and sporopollenin groups) and in the chitinous body walls of Sabellidites sharply contrast to the labile biopolymers in Ediacaran metazoans known only from impressions. The newly emerging biosynthesis of resistant biopolymers in metazoans (chitin and collagen groups) initiated by the annelids at the end of Ediacaran and fully evolved in Cambrian metazoans, considered with the ability to biomineralize, made their body preservation possible. The Chengjiang and Burgess Shale metazoans show evidence of this new biochemistry in body walls and cuticles, and not only because of the specific taphonomic window that enhanced their preservation.Divergence of Proterozoic-Cambrian phytoplankton and timing of the symbiotic origins of chlorophyte alga